The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Stable corneal regeneration four years after implantation of a cell-free recombinant human collagen scaffold
Open accessAbstract
We developed cell-free implants, comprising carbodiimide crosslinked recombinant human collagen (RHC), to enable corneal regeneration by endogenous cell recruitment, to address the worldwide shortage of donor corneas. Patients were grafted with RHC implants. Over four years, the regenerated neo-corneas were stably integrated without rejection, without the long immunosuppression regime needed by donor cornea patients. There was no recruitment of inflammatory dendritic cells into the implant area, whereas, even with immunosuppression, donor cornea recipients showed dendritic cell migration into the central cornea and a rejection episode was observed. Regeneration as evidenced by continued nerve and stromal cell repopulation occurred over the four years to approximate the micro-architecture of healthy corneas. Histopathology of a regenerated, clear cornea from a regrafted patient showed normal corneal architecture. Donor human cornea grafted eyes had abnormally tortuous nerves and stromal cell death was found. Implanted patients had a 4-year average corrected visual acuity of 20/54 and gained more than 5 Snellen lines of vision on an eye chart. The visual acuity can be improved with more robust materials for better shape retention. Nevertheless, these RHC implants can achieve stable regeneration and therefore, represent a potentially safe alternative to donor organ transplantation.
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Cites
Corneal nerves: structure, contents and function
Müller, L. J., Marfurt, C. F., Kruse, F., & Tervo, T. M. T. (2003) · Experimental Eye Research · doi:10.1016/s0014-4835(03)00050-2 · Cited by 1,220
Tan, D. T., Dart, J. K., Holland, E. J., & Kinoshita, S. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60437-1 · Cited by 799
(2008) · Oxford University Press eBooks · doi:10.1093/acref/9780195306613.001.0001 · Cited by 502
Fagerholm, P., Lagali, N. S., Merrett, K., Jackson, W. B., Munger, R., Liu, Y., Polarek, J. W., Söderqvist, M., & Griffith, M. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001022 · Cited by 420
Self-citationA comparison of biomechanical properties between human and porcine cornea
Zeng, Y., Yang, J., Huang, K., Lee, Z., & Lee, X. (2001) · Journal of Biomechanics · doi:10.1016/s0021-9290(00)00219-0 · Cited by 316
Hamrah, P., Zhang, Q., Liu, Y., & Dana, M. R. (2002) · PubMed · Cited by 286
Self-citationThe mechanical properties of the rabbit and human cornea
Jue, B., & Maurice, D. M. (1986) · Journal of Biomechanics · doi:10.1016/0021-9290(86)90135-1 · Cited by 222
Mastropasqua, L., Nubile, M., Lanzini, M., Carpineto, P., Ciancaglini, M., Pannellini, T., Di Nicola, M., & Dua, H. S. (2006) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2006.06.057 · Cited by 214
A Simple, Cross-linked Collagen Tissue Substitute for Corneal Implantation
Liu, Y., Gan, L., Carlsson, D. J., Fagerholm, P., Lagali, N., Watsky, M. A., Munger, R., Hodge, W. G., Priest, D., & Griffith, M. (2006) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.05-1339 · Cited by 207
Self-citationVisual outcome in corneal grafts: a preliminary analysis of the Swedish Corneal Transplant Register
Claesson, M. (2002) · British Journal of Ophthalmology · doi:10.1136/bjo.86.2.174 · Cited by 178
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Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review
Fatimi, A., Okoro, O. V., Podstawczyk, D., Siminska-Stanny, J., & Shavandi, A. (2022) · Gels · doi:10.3390/gels8030179 · Cited by 276
Fertala, A. (2020) · Bioengineering · doi:10.3390/bioengineering7040155 · Cited by 109
Huang, Y.-H., Tseng, F.-W., Chang, W.-H., Peng, I.-C., Hsieh, D.-J., Wu, S.-W., & Yeh, M.-L. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.05.060 · Cited by 96
Metadata
- Authors
- Fagerholm, P., Lagali, N. S., Ong, J. A., Merrett, K., Jackson, W. B., Polarek, J. W., Suuronen, E. J., Liu, Y., Brunette, I., & Griffith, M.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 35
- Issue
- 8
- Pages
- 2420-2427
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2152635187
- Cited by
- 299
- References
- 19
- FWCI
- 14.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Fagerholm, P., Lagali, N. S., Ong, J. A., Merrett, K., Jackson, W. B., Polarek, J. W., Suuronen, E. J., Liu, Y., Brunette, I., & Griffith, M. (2014). Stable corneal regeneration four years after implantation of a cell-free recombinant human collagen scaffold. Biomaterials. https://doi.org/10.1016/j.biomaterials.2013.11.079
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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