A biosynthetic alternative to human donor tissue for inducing corneal regeneration: 24-month follow-up of a phase 1 clinical study
Open accessAbstract
A biosynthetic cornea is stably integrated with host tissues for 2 years after implantation and produces nerve regeneration and vision improvement.
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Synthetic collagen gels used in partial thickness grafts appear to act as temporary scaffolds to allow remodelling of the tissue.
“but at present it appears that these gels are acting as temporary scaffolds to allow remodelling of the tissue.”
From Corneal structure and transparency (2015) · cites this paper as Fagerholm et al., 2010
Clinical trials have been carried out on partial thickness grafts using synthetic collagen gels.
“Currently, trials have been carried out on partial thickness grafts using synthetic collagen gels (Fagerholm et al., 2010)”
From Corneal structure and transparency (2015) · cites this paper as Fagerholm et al., 2010
Cites
STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
Martin Bland, J., & Altman, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90837-8 · Cited by 47,965 · see citing works
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Corneal structure and transparency
Meek, K. M., & Knupp, C. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.07.001 · Cited by 853 · see citing works
Tonsomboon, K., & Oyen, M. L. (2013) · Journal of the Mechanical Behavior of Biomedical Materials · doi:10.1016/j.jmbbm.2013.03.001 · Cited by 207 · see citing works
McLaughlin, S., McNeill, B., Podrebarac, J., Hosoyama, K., Sedlakova, V., Cron, G., Smyth, D., Seymour, R., Goel, K., Liang, W., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12748-8 · Cited by 153 · see citing works
Fertala, A. (2020) · Bioengineering · doi:10.3390/bioengineering7040155 · Cited by 109 · see citing works
Keeping an Eye on Decellularized Corneas: A Review of Methods, Characterization and Applications
Wilson, S., Sidney, L., Dunphy, S., Rose, J., & Hopkinson, A. (2013) · Journal of Functional Biomaterials · doi:10.3390/jfb4030114 · Cited by 100 · see citing works
Huang, Y.-H., Tseng, F.-W., Chang, W.-H., Peng, I.-C., Hsieh, D.-J., Wu, S.-W., & Yeh, M.-L. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.05.060 · Cited by 96 · see citing works
Improved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Molecules
Hsu, C.-W., Poché, R. A., Saik, J. E., Ali, S., Wang, S., Yosef, N., Calderon, G. A., Scott, L., Vadakkan, T. J., Larina, I. V., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0131643 · Cited by 56 · see citing works
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Chakraborty, J., Roy, S., Murab, S., Ravani, R., Kaur, K., Devi, S., Singh, D., Sharma, S., Mohanty, S., Dinda, A. K., et al. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b00251 · Cited by 42 · see citing works
Aslan, B., Guler, S., Tevlek, A., & Aydin, H. M. (2018) · Journal of Biomedical Materials Research Part B: Applied Biomaterials · doi:10.1002/jbm.b.34022 · Cited by 40 · see citing works
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- Authors
- Fagerholm, P., Lagali, N. S., Merrett, K., Jackson, W. B., Munger, R., Liu, Y., Polarek, J. W., Söderqvist, M., & Griffith, M.
- Affiliations
- Linköping University (SE)
- University of Ottawa (CA)
- University of Ottawa Eye Institute, Ottawa, Ontario, Canada K1H 8L6.
- CooperVision Inc., 5870 Stoneridge Drive, Suite 1, Pleasanton, CA 94588, USA.
- FibroGen (United States) (US)
- Synsam Opticians, Box 362, Trädgårdstorget 2, 581 03 Linköping, Sweden.
- Corresponding author
- Fagerholm, Per
- Lagali, Neil S.
- Griffith, May
- Venue
- Science Translational Medicine
- Published
- 2010-08-25
- Volume
- 2
- Issue
- 46
- Pages
- 46ra61-46ra61
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2120258242
- Cited by
- 420
- References
- 1
- Citations by year
- 2026: 28 · 2025: 17 · 2024: 20 · 2023: 19 · 2022: 26 · 2021: 31 · 2020: 27 · 2019: 33 · 2018: 22 · 2017: 31 · 2016: 34 · 2015: 26 · 2014: 34 · 2013: 32 · 2012: 19
- FWCI
- 18.70
- Type
- journal article
- Language
- en
- Open access
- green
- urn.kb.se
- Licence
- other-oa
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal Surgery and Treatments
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal surgery and disorders
- Keywords
- corneal regeneration, corneal extracellular matrix, donor cornea shortage, corneal blindness, corneal re-epithelialization, nerve regeneration, tactile sensitivity, vision loss
- MeSH terms
- Adolescent, Adult, Aged, Astigmatism, Cornea, Extracellular Matrix, Follow-Up Studies, Humans, Keratoconus, Middle Aged, Regeneration, Tissue Donors, Visual Acuity
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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