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Cited by 234

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Dual imaging-guided photothermal/photodynamic therapy using micelles

Open access
Guo, Miao, Mao, Huajian, Li, Yanli, Zhu, Aijun, He, Hui, Yang, Hong, Wang, Yangyun, Tian, Xin, Ge, Cuicui, Peng, Qiaoli, Wang, Xiaoyong, Yang, Xiangliang, Chen, Xiaoyuan, Liu, Gang, Chen, Huabing·2014·Biomaterials

Abstract

We report a type of photosensitizer (PS)-loaded micelles integrating cyanine dye as potential theranostic micelles for precise anatomical tumor localization via dual photoacoustic (PA)/near-infrared fluorescent (NIRF) imaging modalities, and simultaneously superior cancer therapy via sequential synergistic photothermal therapy (PTT)/photodynamic therapy (PDT). The micelles exhibit enhanced photostability, cell internalization and tumor accumulation. The dual NIRF/PA imaging modalities of the micelles cause the high imaging contrast and spatial resolution of tumors, which provide precise anatomical localization of the tumor and its inner vasculature for guiding PTT/PDT treatments. Moreover, the micelles can generate severe photothermal damage on cancer cells and destabilization of the lysosomes upon PTT photo-irradiation, which subsequently facilitate synergistic photodynamic injury via PS under PDT treatment. The sequential treatments of PTT/PDT trigger the enhanced cytoplasmic delivery of PS, which contributes to the synergistic anticancer efficacy of PS. Our strategy provides a dual-modal cancer imaging with high imaging contrast and spatial resolution, and subsequent therapeutic synergy of PTT/PDT for potential multimodal theranostic application.

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Metadata

Authors
Guo, M., Mao, H., Li, Y., Zhu, A., He, H., Yang, H., Wang, Y., Tian, X., Ge, C., Peng, Q., Wang, X., Yang, X., Chen, X., Liu, G., & Chen, H.
Venue
Biomaterials
Publisher
Elsevier BV
Published
2014-05
Volume
35
Issue
16
Pages
4656-4666
ISSN
0142-9612 (ISSN-L)
OpenAlex
W2089354064
Cited by
234
References
2
FWCI
18.37
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Dual imaging-guided photothermal/photodynamic therapy using micelles. https://app.cochat.ai/papers/10.1016/j.biomaterials.2014.02.018
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Guo, M., Mao, H., Li, Y., Zhu, A., He, H., Yang, H., Wang, Y., Tian, X., Ge, C., Peng, Q., Wang, X., Yang, X., Chen, X., Liu, G., & Chen, H. (2014). Dual imaging-guided photothermal/photodynamic therapy using micelles. Biomaterials. https://doi.org/10.1016/j.biomaterials.2014.02.018

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