The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer
Open accessAbstract
Prostate cancer is the most commonly diagnosed cancer disease in men in the Unites States and its management remains challenge in everyday oncology practice. Thus, advanced therapeutic strategies are required to treat prostate cancer patients. Curcumin (CUR) is a promising anticancer agent for various cancer types. The objective of this study was to evaluate therapeutic potential of novel poly(lactic-co-glycolic acid)- CUR nanoparticles (PLGA-CUR NPs) for prostate cancer treatment. Our results indicate that PLGA-CUR NPs efficiently internalize in prostate cancer cells and release biologically active CUR in cytosolic compartment of cells for effective therapeutic activity. Cell proliferation (MTS), clonogenic, and Western blot analyses reveal that PLGA-CUR NPs can effectively inhibit proliferation and colony formation ability of prostate cancer cells than free CUR. PLGA-CUR NPs showed superior tumor regression compared to CUR in xenograft mice. Further investigations reveal that PLGA-CUR NPs inhibit nuclear β-catenin and AR expression in cells and in tumor xenograft tissues. It also suppresses STAT3 and AKT phosphorylation and leads to apoptosis via inhibition of key anti-apoptotic proteins, MCL-1, Bcl-xL and caused induction of PARP cleavage. Additionally, PLGA-CUR NPs significant downregulation of oncogenic miR21 and up-regulation of miR-205 was observed with PLGA-CUR NPs treatment as determined by RT-PCR and in situ hybridization analyses. A superior anti-cancer potential was attained with PSMA antibody conjugated PLGA-CUR NPs in prostate cancer cells and a significant tumor targeting of 131I labelled PSMA antibody was achieved with PLGA-CUR NPs in prostate cancer xenograft mice model. In conclusion, PLGA-CUR NPs can significantly accumulate and exhibit superior anticancer activity in prostate cancer.
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Cites
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Bioavailability of curcumin: Problems and promises
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“It is important to note that a trace amount of curcumin was detected in the serum of humanwhen up to 4e12 g/day of CUR was administered [12].”
PLGA-based nanoparticles: An overview of biomedical applications
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CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans
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Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?
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Cited by
McCubrey, J. A., Lertpiriyapong, K., Steelman, L. S., Abrams, S. L., Yang, L. V., Murata, R. M., Rosalen, P. L., Scalisi, A., Neri, L. M., Cocco, L., et al. (2017) · Aging · doi:10.18632/aging.101250 · Cited by 285
MicroRNA: A novel target of curcumin in cancer therapy
Mirzaei, H., Masoudifar, A., Sahebkar, A., Zare, N., Sadri Nahand, J., Rashidi, B., Mehrabian, E., Mohammadi, M., Mirzaei, H. R., & Jaafari, M. R. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26055 · Cited by 236
Metadata
- Authors
- Yallapu, M. M., Khan, S., Maher, D. M., Ebeling, M. C., Sundram, V., Chauhan, N., Ganju, A., Balakrishna, S., Gupta, B. K., Zafar, N., Jaggi, M., & Chauhan, S. C.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 35
- Issue
- 30
- Pages
- 8635-8648
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1988943017
- Cited by
- 290
- References
- 51
- FWCI
- 10.77
- Type
- journal article
- Language
- en
- Open access
- green
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