Bioavailability of curcumin: Problems and promises

Anand, Preetha; Kunnumakkara, Ajaikumar B.; Newman, Robert A.; Aggarwal, Bharat B.

doi:10.1021/mp700113r

Cited by 5,543Curcumin's Biomedical ApplicationsDrug Solubulity and Delivery SystemsPiperaceae Chemical and Biological Studies

Bioavailability of curcumin: Problems and promises

Anand, Preetha, Kunnumakkara, Ajaikumar B., Newman, Robert A., Aggarwal, Bharat B.·2007·Molecular Pharmaceutics

DOI 10.1021/mp700113r

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Abstract

Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Phase I clinical trials have shown that curcumin is safe even at high doses (12 g/day) in humans but exhibit poor bioavailability. Major reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination. To improve the bioavailability of curcumin, numerous approaches have been undertaken. These approaches involve, first, the use of adjuvant like piperine that interferes with glucuronidation; second, the use of liposomal curcumin; third, curcumin nanoparticles; fourth, the use of curcumin phospholipid complex; and fifth, the use of structural analogues of curcumin (e.g., EF-24). The latter has been reported to have a rapid absorption with a peak plasma half-life. Despite the lower bioavailability, therapeutic efficacy of curcumin against various human diseases, including cancer, cardiovascular diseases, diabetes, arthritis, neurological diseases and Crohn's disease, has been documented. Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease.

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Poor bioavailability is the reason for too low brain uptake of curcumin.
“Poor bioavailability it’s the reason for too low brain uptake of curcumin [220].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [220]
Due to curcumin's inefficient penetration of the blood-brain barrier, nominal bioavailability, and quick gastrointestinal metabolism, various curcumin analogs have been tested.
“Nonetheless, due to curcumin’s inefficient penetration of the BBB, nominal bioavailability, and quick gastrointestinal metabolism, various curcumin analogs have been tested [157,158,159].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [157]
Curcumin has low bioavailability.
“Likewise, low bioavailability, such as that observed with curcumin, is also a major issue [157].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [157]

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Authors: Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
Corresponding author: Aggarwal, Bharat B.
ORCID: Kunnumakkara, Ajaikumar B.
Newman, Robert A.
Aggarwal, Bharat B.
Venue: Molecular Pharmaceutics
Publisher: American Chemical Society (ACS)
Published: 2007-11-14
Volume: 4
Issue: 6
Pages: 807-818
ISSN: 1543-8384 (ISSN-L)
1543-8392
DOI: 10.1021/mp700113r
OpenAlex: W1976194786
Cited by: 5,543
References: 82
Citations by year: 2026: 364 · 2025: 360 · 2024: 320 · 2023: 415 · 2022: 403 · 2021: 436 · 2020: 429 · 2019: 367 · 2018: 312 · 2017: 349 · 2016: 377 · 2015: 307 · 2014: 291 · 2013: 237 · 2012: 207
FWCI: 4.00
Type: journal article
Language: en
Open access: closed
Locations: Molecular Pharmaceutics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Piperaceae Chemical and Biological Studies
Keywords: curcumin, bioavailability, turmeric, piperine, glucuronidation inhibition, liposomal curcumin, curcumin nanoparticles, phospholipid complex, drug absorption, drug metabolism, anti-inflammatory activity, antioxidant activity, cancer therapy, cardiovascular disease, diabetes mellitus, arthritis, neurological disorders, Crohn's disease
MeSH terms: Animals, Biological Availability, Curcumin, Humans, Tissue Distribution, Drug Delivery Systems

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