USPIO-labeled textile materials for non-invasive MR imaging of tissue-engineered vascular grafts
Abstract
Non-invasive imaging might assist in the clinical translation of tissue-engineered vascular grafts (TEVG). It can e.g. be used to facilitate the implantation of TEVG, to longitudinally monitor their localization and function, and to provide non-invasive and quantitative feedback on their remodeling and resorption. We here incorporated ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles into polyvinylidene fluoride (PVDF)-based textile fibers, and used them to prepare imageable tissue-engineered vascular grafts (iTEVG). The USPIO-labeled scaffold materials were molded with a mixture of fibrin, fibroblasts and smooth muscle cells, and then endothelialized in a bioreactor under physiological flow conditions. The resulting grafts could be sensitively detected using T1-, T2- and T2*-weighted MRI, both during bioreactor cultivation and upon surgical implantation into sheep, in which they were used as an arteriovenous shunt between the carotid artery and the jugular vein. In vivo, the iTEVG were shown to be biocompatible and functional. Post-mortem ex vivo analyses provided evidence for efficient endothelialization and for endogenous neo-vascularization within the biohybrid vessel wall. These findings show that labeling polymer-based textile materials with MR contrast agents is straightforward and safe, and they indicate that such theranostic tissue engineering approaches might be highly useful for improving the production, performance, personalization and translation of biohybrid vascular grafts.
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Several clinical studies have been performed with SPION-loaded cells, including labeled neuronal stem cells for traumatic brain injury and labeled pancreatic islet cells for diabetes.
“Several clinical studies have been performed with SPION-loaded cells, including e.g. labeled neuronal stem cells for traumatic brain injury and labeled pancreatic islet cells for diabetes [257, 258].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [258]
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Meet the Editorial Board Member
Kiessling, F. M. (2022) · Current Medicinal Chemistry · doi:10.2174/092986732909220307125520
Meet Our Editorial Board Member
Kiessling, F. M. (2021) · Current Medicinal Chemistry · doi:10.2174/092986732809210415074108
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- Authors
- Mertens, M. E., Koch, S., Schuster, P., Wehner, J., Wu, Z., Gremse, F., Schulz, V., Rongen, L., Wolf, F., Frese, J., Gesché, V. N., van Zandvoort, M., Mela, P., Jockenhoevel, S., Kiessling, F., & Lammers, T.
- Affiliations
- RWTH Aachen University (DE)
- Universitätsklinikum Aachen (DE)
- Corresponding author
- Jockenhoevel, Stefan
- Kiessling, Fabian
- Lammers, Twan
- ORCID
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 39
- Pages
- 155-163
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1976086609
- Cited by
- 71
- References
- 27
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 9 · 2019: 13 · 2018: 8 · 2017: 5 · 2016: 10 · 2015: 4
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- University of Twente Research Information (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- University of Twente Research Information (submittedVersion)
- Funders
- NRW/EU-Ziel 2-Programm (EFRE) 2007–2013
- Helmholtz-Society Portfolio
- European Research Council (309495)
- ERS Boost Fund Program
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- tissue-engineered vascular grafts, superparamagnetic iron oxide nanoparticles, MRI contrast agents, non-invasive imaging, endothelialization, arteriovenous shunt, graft remodeling, theranostics, sheep model
- MeSH terms
- Animals, Blood Vessel Prosthesis, Cells, Cultured, Dextrans, Magnetic Resonance Imaging, Sheep, Textiles, Tissue Engineering, Magnetite Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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