The DOI matches its Crossref record; 67 of the 68 references it cites were found in a registry or an index.
Graphene quantum dots conjugated neuroprotective peptide improve learning and memory capability
Abstract
Alzheimer disease (AD) is a neurodegenerative disorder and the most common form of dementia. Histopathologically is characterized by the presence extracellular neuritic plaques and with a large number of neurons lost. In this paper, we design a new nanomaterial, graphene quantum dots (GQDs) conjugated neuroprotective peptide glycine-proline-glutamate (GQDG) and administer it to APP/PS1 transgenic mice. The in vitro assays including ThT and CD proved that GQDs and GQDG could inhibit the aggregation of Aβ1-42 fibrils. Morris water maze was performed to exanimate learning and memory capacity of APP/PS1 transgenic mice. The surface area of Aβ plaque deposits reduced in the GQDG group compared to the Tg Ctrl groups. Furthermore, newly generated neuronal precursor cell and neuron were test by immunohistochemical. Besides, neurons were impregnated by DiI using gene gun to show dendritic spine. Results indicated enhancement of learning and memory capacity and increased amounts of dendritic spine were observed. Inflammation factors and amyloid-β (Aβ) were tested with suspension array and ELISA, respectively. Several pro-inflammatory cytokines (IL-1α, IL-1β, IL-6, IL-33, IL-17α, MIP-1β and TNF-α) had decreased in GQDG group compared with Control group. Reversely, anti-inflammatory cytokines (IL-4, IL-10) had increased in GQDG group compared with Control group. Thus, we demonstrate that the GQDG is a promising drug in treatment of neurodegenerative diseases such as AD.
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“Xiao et al. (2016) used graphene quantum dots (GQDs) coated with glycine-proline-glutamate in APP/PS1 transgenic mice. The aggregation of amyloid plaque along with the levels of pro-inflammatory cytokines was reduced whereas the levels of anti-inflammatory cytokines increased, thus demonstrating strong potential as a therapy in AD [112].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [112]
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Graphene quantum dots from chemistry to applications
Tian, P., Tang, L., Teng, K. S., & Lau, S. P. (2018) · Materials Today Chemistry · doi:10.1016/j.mtchem.2018.09.007 · Cited by 899
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease
Khan, S., Barve, K. H., & Kumar, M. S. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200528142429 · Cited by 820
Quantum dots in imaging, drug delivery and sensor applications
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“The GQDGs had an inhibitory effect on the aggregation of amyloid-β fibrils, the number of newly generated neuronal precursor cells and neurons increased.(34)”
Cui, G., Wu, J., Mou, F., Xie, W., Wang, F., Wang, Q., Fang, J., Xu, Y., Dong, Y., Liu, J., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201700600r · Cited by 387
“The data presented in this study found a marked increase in the level of TNF-a and IL-1b and a decrease in the level of IL-4 and -10 in ADmice, which is consistent with a previous report (31).”
ResultSelf-citationCui, G.-H., Guo, H.-D., Li, H., Zhai, Y., Gong, Z., Wu, J., Liu, J.-S., Dong, Y., Hou, S., & Liu, J. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0150-2 · Cited by 359
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Metadata
- Authors
- Xiao, S., Zhou, D., Luan, P., Gu, B., Feng, L., Fan, S., Liao, W., Fang, W., Yang, L., Tao, E., Guo, R., & Liu, J.
- Affiliations
- Sun Yat-sen University (CN)
- Guangdong Provincial Hospital of Chinese Medicine (CN)
- Shenzhen University (CN)
- Jinan University (CN)
- Corresponding author
- Guo, Rui
- Liu, Jun
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 106
- Pages
- 98-110
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2514135347
- Cited by
- 169
- References
- 68
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 25 · 2023: 37 · 2022: 25 · 2021: 22 · 2020: 23 · 2019: 8 · 2018: 11 · 2017: 5
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shenzhen Fundamental Research and Discipline Layout project
- National Natural Science Foundation of China (81372919)
- Natural Science Foundation of Guangdong Province (51303064, 2014A030313016)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Physical Sciences › Materials Science › Materials Chemistry › Carbon and Quantum Dots Applications
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- graphene quantum dots, neuroprotective peptides, Alzheimer's disease, amyloid beta aggregation inhibition, APP/PS1 mice, learning and memory, dendritic spines, neuroinflammation, inflammatory cytokines, anti-inflammatory cytokines, amyloid plaques, nanomaterial drug delivery
- MeSH terms
- Alzheimer Disease, Animals, Graphite, Learning, Male, Memory, Mice, Transgenic, Peptides, Treatment Outcome, Neuroprotective Agents, Quantum Dots, Mice, Nanoconjugates
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