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Graphene quantum dots conjugated neuroprotective peptide improve learning and memory capability
Abstract
Alzheimer disease (AD) is a neurodegenerative disorder and the most common form of dementia. Histopathologically is characterized by the presence extracellular neuritic plaques and with a large number of neurons lost. In this paper, we design a new nanomaterial, graphene quantum dots (GQDs) conjugated neuroprotective peptide glycine-proline-glutamate (GQDG) and administer it to APP/PS1 transgenic mice. The in vitro assays including ThT and CD proved that GQDs and GQDG could inhibit the aggregation of Aβ1-42 fibrils. Morris water maze was performed to exanimate learning and memory capacity of APP/PS1 transgenic mice. The surface area of Aβ plaque deposits reduced in the GQDG group compared to the Tg Ctrl groups. Furthermore, newly generated neuronal precursor cell and neuron were test by immunohistochemical. Besides, neurons were impregnated by DiI using gene gun to show dendritic spine. Results indicated enhancement of learning and memory capacity and increased amounts of dendritic spine were observed. Inflammation factors and amyloid-β (Aβ) were tested with suspension array and ELISA, respectively. Several pro-inflammatory cytokines (IL-1α, IL-1β, IL-6, IL-33, IL-17α, MIP-1β and TNF-α) had decreased in GQDG group compared with Control group. Reversely, anti-inflammatory cytokines (IL-4, IL-10) had increased in GQDG group compared with Control group. Thus, we demonstrate that the GQDG is a promising drug in treatment of neurodegenerative diseases such as AD.
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“Xiao et al. (2016) used graphene quantum dots (GQDs) coated with glycine-proline-glutamate in APP/PS1 transgenic mice. The aggregation of amyloid plaque along with the levels of pro-inflammatory cytokines was reduced whereas the levels of anti-inflammatory cytokines increased, thus demonstrating strong potential as a therapy in AD [112].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [112]
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Ding, N., Zhou, F., Li, G., Shen, H. Y., Bai, L., & Su, J. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101167 · Cited by 23
“GQDs bind to this neuro-protective peptide by preventing β -amyloid protein aggregation improved the effectiveness of treatment and significantly improved the condition of APP/PS1 transgenic mice in the experiment [78].”
BackgroundXu, H., Wang, X., Zhang, X., Cheng, J., Zhang, J., Chen, M., & Wu, T. (2021) · Nanomaterials · doi:10.3390/nano11123314 · Cited by 18
Nanotherapeutics for Alleviating Anesthesia‐Associated Complications
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“…results were similar to previous studies that the expression of proinflammatory factors including NF-κ B, TNF-(cid:4) , and IL-1 (cid:2) in the brain of APP/PS1 mice [54] and 3xTg-AD mice [55, 56] significantly increased, but the content of anti-inflammatory factor IL-10 significantly reduced [57].”
Cell Surface Transporters and Novel Drug Developments
Carmichael, N. S., & Day, P. J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.852938 · Cited by 16
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Nanotechnology in Drug Delivery Systems: Ways to Boost Bioavailability of Drugs
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Amyloid –β pathology in Alzheimer’s disease: A nano delivery approach
Meghana, G. S., Gowda, D., Chidambaram, S. B., & Osmani, R. A. M. (2023) · Vibrational Spectroscopy · doi:10.1016/j.vibspec.2023.103510 · Cited by 17
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Huo, S., Ren, J., Ma, Y., Ozathaley, A., Yuan, W., Ni, H., Li, D., & Liu, Z. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02321-w · Cited by 16
Blocking tau transmission by biomimetic graphene nanoparticles
Zhu, R., Makwana, K. M., Zhang, Y., Rajewski, B. H., Valle, J. R. D., & Wang, Y. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb00850a · Cited by 18
Alzheimer's Disease: Status of Low‐Dimensional Nanotherapeutic Materials
Huang, D., Liao, W., Li, J., Chen, T., Wang, X., Zhao, R., Zhang, L., Yu, X., Zheng, D., & Luan, P. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202302015 · Cited by 15
Self-citationTak, K., Sharma, P., Sharma, R., Dave, V., Jain, S., & Sharma, S. K. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103486 · Cited by 14
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“73 It is worth noting that the MoS2 complex has also been found in studies to have a therapeutic effect on Alzheimer’s disease.”
BackgroundApplication of carbon dots-based nanomaterials in amyloid aggregation disease
Yan, C., Shao, X., Wang, Y., Tang, S., Li, S., Wang, C., Bai, M., Qi, Y., Ma, Y., Zhao, R., et al. (2024) · Carbon · doi:10.1016/j.carbon.2024.119971 · Cited by 13
The importance of the IL ‐1 family of cytokines in nanoimmunosafety and nanotoxicology
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Metadata
- Authors
- Xiao, S., Zhou, D., Luan, P., Gu, B., Feng, L., Fan, S., Liao, W., Fang, W., Yang, L., Tao, E., Guo, R., & Liu, J.
- Affiliations
- Sun Yat-sen University (CN)
- Guangdong Provincial Hospital of Chinese Medicine (CN)
- Shenzhen University (CN)
- Jinan University (CN)
- Corresponding author
- Guo, Rui
- Liu, Jun
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 106
- Pages
- 98-110
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2514135347
- Cited by
- 169
- References
- 68
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 25 · 2023: 37 · 2022: 25 · 2021: 22 · 2020: 23 · 2019: 8 · 2018: 11 · 2017: 5
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shenzhen Fundamental Research and Discipline Layout project
- National Natural Science Foundation of China (81372919)
- Natural Science Foundation of Guangdong Province (51303064, 2014A030313016)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Physical Sciences › Materials Science › Materials Chemistry › Carbon and Quantum Dots Applications
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- graphene quantum dots, neuroprotective peptides, Alzheimer's disease, amyloid beta aggregation inhibition, APP/PS1 mice, learning and memory, dendritic spines, neuroinflammation, inflammatory cytokines, anti-inflammatory cytokines, amyloid plaques, nanomaterial drug delivery
- MeSH terms
- Alzheimer Disease, Animals, Graphite, Learning, Male, Memory, Mice, Transgenic, Peptides, Treatment Outcome, Neuroprotective Agents, Quantum Dots, Mice, Nanoconjugates
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