The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Reactive oxygen species scavenging with a biodegradable, thermally responsive hydrogel compatible with soft tissue injection
Abstract
Tissue damage and the impairment of regenerative processes by excessive reactive oxygen species (ROS) contributes to the pathogenesis of various diseases in soft tissues including diabetes, atherosclerosis, Parkinson's disease and myocardial ischemic/reperfusion injury. In this study, a thermally responsive injectable hydrogel poly(NIPAAm-co-VP-co-MAPLA-co-MATEMPO) (pNVMT, NIPAAm: N-isopropylacrylamide, VP: vinylpyrrolidone, MAPLA: methacrylate-polylactide, MATEMPO: methacrylate-TEMPO, TEMPO: 4-amino-TEMPO or 4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl) incorporating recyclable ROS scavenging nitroxide radicals on the polymer backbone was developed to locally control adverse tissue effects from free radical generation. In an in vitro oxidative environment, TEMPO Gel significantly preserved cell viability. In a rat myocardial infarction/reperfusion model, TEMPO Gel diffused through the infarcted myocardium, integrated with the tissue upon gelation, and remained for over one week as visualized by MRI. The TEMPO Gel reduced infarction/reperfusion injury and preserved left ventricle geometry. This thermally responsive hydrogel was demonstrated to have properties desirable for local application to soft tissue beds where oxidative damage by ROS is of concern in pathological mechanisms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
Zorov, D. B., Juhaszova, M., & Sollott, S. J. (2014) · Physiological Reviews · doi:10.1152/physrev.00026.2013 · Cited by 5,383
The Role of Oxidative Stress in Parkinson's Disease
Dias, V., Junn, E., & Mouradian, M. M. (2013) · Journal of Parkinson’s Disease · doi:10.3233/jpd-130230 · Cited by 1,845
Reactive oxygen species enhance insulin sensitivity
Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B. J., Skiba, B., Ooms, L. M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.009 · Cited by 581
Reactive oxygen species and fibrosis: further evidence of a significant liaison
Richter, K., & Kietzmann, T. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2445-3 · Cited by 322
Cited by
Guan, Y., Niu, H., Liu, Z., Dang, Y., Shen, J., Zayed, M., Ma, L., & Guan, J. (2021) · Science Advances · doi:10.1126/sciadv.abj0153 · Cited by 631
El-Husseiny, H. M., Mady, E. A., Hamabe, L., Abugomaa, A., Shimada, K., Yoshida, T., Tanaka, T., Yokoi, A., Elbadawy, M., & Tanaka, R. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2021.100186 · Cited by 533
Wearable and implantable devices for drug delivery: Applications and challenges
Kar, A., Ahamad, N., Dewani, M., Awasthi, L., Patil, R., & Banerjee, R. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121435 · Cited by 179
Anti-oxidative and anti-inflammatory micelles: break the dry eye vicious cycle
Li, S., Lu, Z., Huang, Y., Wang, Y., Jin, Q., Shentu, X., Ye, J., Ji, J., Yao, K., & Han, H. (2022) · Advanced Science · doi:10.1002/advs.202200435 · Cited by 174
Metadata
- Authors
- Zhu, Y., Matsumura, Y., Velayutham, M., Foley, L. M., Hitchens, T. K., & Wagner, W. R.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 177
- Pages
- 98-112
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2807549623
- Cited by
- 180
- References
- 4
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Reactive oxygen species scavenging with a biodegradable, thermally responsive hydrogel compatible with soft tissue injection. https://app.cochat.ai/papers/10.1016/j.biomaterials.2018.05.044
- The paper
- Zhu, Y., Matsumura, Y., Velayutham, M., Foley, L. M., Hitchens, T. K., & Wagner, W. R. (2018). Reactive oxygen species scavenging with a biodegradable, thermally responsive hydrogel compatible with soft tissue injection. Biomaterials. https://doi.org/10.1016/j.biomaterials.2018.05.044
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
