Cited by 179Advancements in Transdermal Drug DeliveryAdvanced Drug Delivery SystemsTissue Engineering and Regenerative Medicine

Wearable and implantable devices for drug delivery: Applications and challenges

Kar, Abhinanda, Ahamad, Nadim, Dewani, Mahima, Awasthi, Lisha, Patil, Runali, Banerjee, Rinti·2022·Biomaterials

Abstract

Poor adherence to drug dosing schedule is responsible for ∼50% of hospitalization cases. Most patients fail to adhere to a strict dosing schedule due to invasive drug administration, off-target toxicities, or medical conditions like dementia. The emerging concept of wearable devices (WDs), implantable devices (IDs) and combined wearable and implantable devices (WIDs) for drug delivery has created new opportunities for treating patients with chronic diseases needing repeated and long-term medical attention like diabetes, ocular disorders, cancer, wound healing, cardiovascular diseases, and contraception. WDs, worn on the body surface have created appealing non-invasive, self-administrable drug delivery platforms which receive huge patient compliance. Microneedle-skin patches, wound healing patches, drug-eluting contact lenses, mouth guards, intra-vaginal rings, pharmaceutical jewelry, and drug-loaded self-care textiles are popular WDs explored in drug delivery. In contrast, IDs are surgically placed inside body tissue allowing higher payload and enhanced localized effect for an extended duration. Hormone micropumps, hydrogel/nanofibrous depot, coronary stents, intravitreal devices, and intrauterine devices are some representative examples of IDs. In this review, we have described the past 10 years of research progress on drug-delivering WDs and IDs in the context of treating diseases that demand repeated and long-term medication, especially those affecting soft tissues. We highlighted several technical challenges that need to be addressed before considering the translation of such technologies to clinics.

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Crossref · 10.1016/j.biomaterials.2022.121435

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  • Wearable delivery devices have been used to deliver a range of therapeutic agents, including polypeptides, polysaccharides, small molecules, and growth factors, continuously and responsively.

    “These devices have been used to deliver a range of therapeutic agents, including polypeptides, polysaccharides, small molecules, and growth factors, continuously and responsively (Kar et al. 2022; Yang, Yuan et al. 2022a; Yang, Yuan et al. 2022b).”

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Authors
Kar, A., Ahamad, N., Dewani, M., Awasthi, L., Patil, R., & Banerjee, R.
Affiliations
Indian Institute of Technology Bombay (IN)
Corresponding author
  • Ahamad, Nadim
  • Banerjee, Rinti
Venue
Biomaterials
Publisher
Elsevier BV
Published
2022-04
Volume
283
Pages
121435
ISSN
0142-9612 (ISSN-L)
OpenAlex
W4214555582
Cited by
179
References
274
Citations by year
2026: 36 · 2025: 53 · 2024: 42 · 2023: 39 · 2022: 9
FWCI
3.13
Type
journal article
Language
en
Open access
closed
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education, India
  • Department of Biotechnology, Ministry of Science and Technology, India
  • Indian Institute of Technology Bombay (20001208)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
implantable drug delivery, medication adherence, drug-eluting contact lenses, coronary stents, intrauterine devices, chronic disease treatment, non-invasive drug delivery
MeSH terms
Wearable Electronic Devices, Diabetes Mellitus, Pharmaceutical Preparations, Female, Humans, Drug Delivery Systems, Prostheses and Implants

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