The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Remote eradication of biofilm on titanium implant via near-infrared light triggered photothermal/photodynamic therapy strategy
Open accessAbstract
Biofilm formation is a main challenge in treatment of bone-implant-associated infections, resulting in tolerance to immune system and antibiotics. However, smart non-surgical or non-invasive treatment methods of combating established biofilm on an implant have been less reported. Herein, a therapeutic system consisting of mesoporous polydopamine nanoparticles (MPDA) to combat biofilm is reported for the first time. We develop a synergistic photothermal/photodynamic therapy (PTT/PDT) strategy aiming for biofilms eradication on titanium (Ti) implant, which is integrated with MPDA loading with photosensitizer Indocyanine Green (ICG) by π-π stacking. Specifically, MPDA is functionalized with RGD peptide to endow the modified Ti sample (Ti-M/I/RGD) with good cytocompatibility. More importantly, Ti-M/I/RGD implant remarkably kills Staphylococcus aureus (S. aureus) biofilm with an efficiency of 95.4% in vivo upon near infrared (NIR). After biofilm eradication, implant still displays great performance regarding osteogenesis and osseointegration. Overall, this study provides a PTT/PDT strtategy for the development of antibacterial Ti implants for potential orthpediac application.
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Flemming, H.-C., & Wingender, J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2415 · Cited by 10,137
New Perspectives in Cell Adhesion: RGD and Integrins
Ruoslahti, E., & Pierschbacher, M. D. (1987) · Science · doi:10.1126/science.2821619 · Cited by 4,865
Zimmerli, W., Trampuz, A., & Ochsner, P. E. (2004) · New England Journal of Medicine · doi:10.1056/nejmra040181 · Cited by 3,116
Functional Nanomaterials for Phototherapies of Cancer
Cheng, L., Wang, C., Feng, L., Yang, K., & Liu, Z. (2014) · Chemical Reviews · doi:10.1021/cr400532z · Cited by 2,425
Liu, Y., Ai, K., Liu, J., Deng, M., He, Y., & Lu, L. (2013) · Advanced Materials · doi:10.1002/adma.201204683 · Cited by 2,019
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Kurtz, S. M., Lau, E., Watson, H., Schmier, J. K., & Parvizi, J. (2012) · The Journal of Arthroplasty · doi:10.1016/j.arth.2012.02.022 · Cited by 1,702
Facile Conjugation of Biomolecules onto Surfaces via Mussel Adhesive Protein Inspired Coatings
Lee, H., Rho, J., & Messersmith, P. B. (2009) · Advanced Materials · doi:10.1002/adma.200801222 · Cited by 1,495
Non‐Covalent Self‐Assembly and Covalent Polymerization Co‐Contribute to Polydopamine Formation
Hong, S., Na, Y. S., Choi, S., Song, I. T., Kim, W. Y., & Lee, H. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201201156 · Cited by 1,360
Yin, W., Yu, J., Lv, F., Yan, L., Zheng, L. R., Gu, Z., & Zhao, Y. (2016) · ACS Nano · doi:10.1021/acsnano.6b05810 · Cited by 1,003
Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control
Liu, Y., Shi, L., Su, L., van der Mei, H. C., Jutte, P. C., Ren, Y., & Busscher, H. J. (2019) · Chemical Society Reviews · doi:10.1039/c7cs00807d · Cited by 737
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Chen, Y., Gao, Y., Chen, Y., Liu, L., Mo, A., & Peng, Q. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.08.055 · Cited by 706
Tissue Engineering and Regenerative Medicine: Achievements, Future, and Sustainability in Asia
Han, F., Wang, J., Ding, L., Hu, Y., Li, W., Yuan, Z., Guo, Q., Zhu, C., Yu, L., Wang, H., et al. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00083 · Cited by 357
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Pinto, R. M., Soares, F. A., Reis, S., Nunes, C., & Van Dijck, P. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00952 · Cited by 309
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Metadata
- Authors
- Yuan, Z., Tao, B., He, Y., Mu, C., Liu, G., Zhang, J., Liao, Q., Liu, P., & Cai, K.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 223
- Pages
- 119479
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2972008018
- Cited by
- 286
- References
- 50
- FWCI
- 30.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yuan, Z., Tao, B., He, Y., Mu, C., Liu, G., Zhang, J., Liao, Q., Liu, P., & Cai, K. (2019). Remote eradication of biofilm on titanium implant via near-infrared light triggered photothermal/photodynamic therapy strategy. Biomaterials. https://doi.org/10.1016/j.biomaterials.2019.119479
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