Extracellular matrix-penetrating nanodrill micelles for liver fibrosis therapy

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Hepatic stellate cells as key target in liver fibrosis

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Liver fibrosis and repair: Immune regulation of wound healing in a solid organ

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Pathobiology of liver fibrosis: a translational success story

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Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

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Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

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Living in the liver: hepatic infections

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Experimental liver fibrosis research: update on animal models, legal issues and translational aspects

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Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy

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Hyaluronidase Embedded in Nanocarrier PEG Shell for Enhanced Tumor Penetration and Highly Efficient Antitumor Efficacy

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Interstitial Collagen Catabolism

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Bromelain Surface Modification Increases the Diffusion of Silica Nanoparticles in the Tumor Extracellular Matrix

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Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib

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Nanotechnology for therapy and imaging of liver diseases

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Corona-Directed Nucleic Acid Delivery into Hepatic Stellate Cells for Liver Fibrosis Therapy

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Modulation of Intracellular Oxygen Pressure by Dual‐Drug Nanoparticles to Enhance Photodynamic Therapy

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The Use of Nanoparticles to Deliver Nitric Oxide to Hepatic Stellate Cells for Treating Liver Fibrosis and Portal Hypertension

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Retinoic acids and hepatic stellate cells in liver disease

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Hepatoprotective and Anti-fibrotic Agents: It's Time to Take the Next Step

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Single-Molecule Tracking of Collagenase on Native Type I Collagen Fibrils Reveals Degradation Mechanism

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Vitamin A-decorated biocompatible micelles for chemogene therapy of liver fibrosis

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Nanotechnology applications for the therapy of liver fibrosis

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Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases

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Carbon Dioxide-Mediated Generation of Hybrid Nanoparticles for Improved Bioavailability of Protein Kinase Inhibitors

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Tracking anti‐fibrotic pathways of nilotinib and imatinib in experimentally induced liver fibrosis: A n insight

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A novel potential biocompatible hyperbranched polyspermine for efficient lung cancer gene therapy

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Current drugs in early development for treating hepatitis C virus-related hepatic fibrosis

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Aerosol delivery of biocompatible dihydroergotamine-loaded PLGA-PSPE polymeric micelles for efficient lung cancer therapy

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Histone-inspired biomimetic polymeric gene vehicles with excellent biocompatibility and enhanced transfection efficacy

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Tyrosine kinase inhibitors: friends or foe in treatment of hepatic fibrosis?

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Liver Fibrosis: Challenges of the New Era

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Organic–Inorganic Hybrid Hollow Nanoparticles Suppress Oxidative Stress and Repair Damaged Tissues for Treatment of Hepatic Fibrosis

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Comparable pharmacokinetics of 85 mg RightSize nilotinib (XS003) and 150 mg Tasigna in healthy volunteers using a hybrid nanoparticle-based formulation platform for protein kinase inhibitors.

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162 Progressive Matrix Crosslinking Limits Reversibility of Liver Fibrosis and is Independent of Tissue Transglutaminase

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Progress in Polymeric Micelles for Drug Delivery Applications

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Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis

Kumar, V., Xin, X., Ma, J., Tan, C., Osna, N. A., & Mahato, R. I. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113888 · Cited by 164 · see citing works

Tumor-activated carrier-free prodrug nanoparticles for targeted cancer Immunotherapy: Preclinical evidence for safe and effective drug delivery

Shim, M. K., Yang, S., Sun, I., & Kim, K. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114177 · Cited by 156 · see citing works

Rational design of polymeric micelles for targeted therapeutic delivery

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Sequential Nano-Penetrators of Capillarized Liver Sinusoids and Extracellular Matrix Barriers for Liver Fibrosis Therapy

Zhang, L.-F., Wang, X.-H., Zhang, C.-L., Lee, J., Duan, B.-W., Xing, L., Li, L., Oh, Y.-K., & Jiang, H.-L. (2022) · ACS Nano · doi:10.1021/acsnano.2c03858 · Cited by 92 · see citing works

Reactive Oxygen Species-Responsive Polypeptide Drug Delivery System Targeted Activated Hepatic Stellate Cells to Ameliorate Liver Fibrosis

Hao, Y., Song, K., Tan, X., Ren, L., Guo, X., Zhou, C., Li, H., Wen, J., Meng, Y., Lin, M., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c07796 · Cited by 92 · see citing works

Nanoengineered mesenchymal stem cell therapy for pulmonary fibrosis in young and aged mice

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Fibroblast activation protein activated antifibrotic peptide delivery attenuates fibrosis in mouse models of liver fibrosis

Lee, J., Byun, J., Shim, G., & Oh, Y.-K. (2022) · Nature Communications · doi:10.1038/s41467-022-29186-8 · Cited by 79 · see citing works

Delivery Strategy to Enhance the Therapeutic Efficacy of Liver Fibrosis via Nanoparticle Drug Delivery Systems

Liu, J., Liu, J., Mu, W., Ma, Q., Zhai, X., Jin, B., Liu, Y., & Zhang, N. (2024) · ACS Nano · doi:10.1021/acsnano.4c02380 · Cited by 74 · see citing works

Improving Outcomes of Tyrosine Kinase Inhibitors in Hepatocellular Carcinoma: New Data and Ongoing Trials

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Multiplexing Nanodrug Ameliorates Liver Fibrosis via ROS Elimination and Inflammation Suppression

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Matrix metalloproteinase-1 decorated polymersomes, a surface-active extracellular matrix therapeutic, potentiates collagen degradation and attenuates early liver fibrosis

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Pathological collagen targeting and penetrating liposomes for idiopathic pulmonary fibrosis therapy

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Restoration of Sinusoid Fenestrae Followed by Targeted Nanoassembly Delivery of an Anti‐Fibrotic Agent Improves Treatment Efficacy in Liver Fibrosis

Li, F., Zhao, Y., Cheng, Z., Wang, Y., Yue, Y., Cheng, X., Sun, J., Atabakhshi‐Kashi, M., Yao, J., Dou, J., et al. (2023) · Advanced Materials · doi:10.1002/adma.202212206 · Cited by 60 · see citing works

Potentialities of nanomaterials for the management and treatment of metabolic syndrome: A new insight

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Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy

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Engineering extracellular matrix to improve drug delivery for cancer therapy

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Collagenase-I decorated co-delivery micelles potentiate extracellular matrix degradation and hepatic stellate cell targeting for liver fibrosis therapy

Zhou, L., Liang, Q., Li, Y., Cao, Y., Li, J., Yang, J., Liu, J., Bi, J., & Liu, Y. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.08.065 · Cited by 51 · see citing works

Nanoparticle-Based Drug Delivery Systems for Induction of Tolerance and Treatment of Autoimmune Diseases

Li, H., Yang, Y., & Sun, T. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.889291 · Cited by 50 · see citing works

Recent Advances in Nanomedicine for the Diagnosis and Therapy of Liver Fibrosis

Bai, X., Su, G., & Zhai, S. (2020) · Nanomaterials · doi:10.3390/nano10101945 · Cited by 50 · see citing works

Vicious Cycle‐Breaking Lipid Nanoparticles Remodeling Multicellular Crosstalk to Reverse Liver Fibrosis

Zhang, L., Deng, W., Huang, Q., Zhang, J., Wang, Y., Zhou, T., Xing, L., & Jiang, H. (2024) · Advanced Materials · doi:10.1002/adma.202311474 · Cited by 47 · see citing works

Co-delivery of miR-29b and germacrone based on cyclic RGD-modified nanoparticles for liver fibrosis therapy

Ji, D., Wang, Q., Zhao, Q., Tong, H., Yu, M., Wang, M., Lu, T., & Jiang, C. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00645-y · Cited by 47 · see citing works

Engineered liposomes targeting hepatic stellate cells overcome pathological barriers and reverse liver fibrosis

Wang, K., Chen, H. H., Zheng, J., Chen, J., Chen, Y., & Yuan, Y. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.02.022 · Cited by 46 · see citing works

Nanotechnology of Tyrosine Kinase Inhibitors in Cancer Therapy: A Perspective

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Zein/Phospholipid Composite Nanoparticles for Successful Delivery of Gallic Acid into aHSCs: Influence of Size, Surface Charge, and Vitamin A Coupling

Radwan, S. A. A., El-Maadawy, W. H., Yousry, C., ElMeshad, A. N., & Shoukri, R. A. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s270242 · Cited by 44 · see citing works

Progress on the pathological tissue microenvironment barrier-modulated nanomedicine

Han, H., Xing, L., Chen, B., Liu, Y., Zhou, T., Wang, Y., Zhang, L., Li, L., Cho, C., & Jiang, H. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115051 · Cited by 41 · see citing works

Clodronate-nintedanib-loaded exosome–liposome hybridization enhances the liver fibrosis therapy by inhibiting Kupffer cell activity

Ji, K., Fan, M., Huang, D., Sun, L., Li, B., Xu, R., Zhang, J., Shao, X., & Chen, Y. (2021) · Biomaterials Science · doi:10.1039/d1bm01663f · Cited by 41 · see citing works

Remodeling of the liver fibrosis microenvironment based on nilotinib-loaded multicatalytic nanozymes with boosted antifibrogenic activity

Jing, H., Ren, Y., Zhou, Y., Xu, M., Křížková, S., Heger, Z., Lü, Q., Wang, S., Liang, X., Adam, V., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.08.020 · Cited by 40 · see citing works

The Potential Application of Magnetic Nanoparticles for Liver Fibrosis Theranostics

Eftekhari, A., Arjmand, A., Asheghvatan, A., Švajdlenková, H., Šauša, O., Abiyev, H., Ahmadian, E., Smutok, O. V., Khalilov, R. I., Kavetskyy, T. S., et al. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.674786 · Cited by 40 · see citing works

An Autologous Macrophage‐Based Phenotypic Transformation‐Collagen Degradation System Treating Advanced Liver Fibrosis

Duan, B., Liu, Y., Li, X., Han, M., Yu, H., Hong, H., Zhang, L., Xing, L., & Jiang, H. (2024) · Advanced Science · doi:10.1002/advs.202306899 · Cited by 38 · see citing works

Hepatic Stellate Cell- and Liver Microbiome-Specific Delivery System for Dihydrotanshinone I to Ameliorate Liver Fibrosis

Niu, X., Meng, Y., Cui, J., Li, R., Ding, X. Q., Niu, B., Chang, G., Xu, N., Li, G., Wang, Y., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c06626 · Cited by 38 · see citing works

Collagenase Type I and Probucol-Loaded Nanoparticles Penetrate the Extracellular Matrix to Target Hepatic Stellate Cells for Hepatic Fibrosis Therapy.

Wang, X., Zhang, W., Zeng, S., Wang, L.-D., & Wang, B. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.12.027 · Cited by 40 · see citing works

Remodeling the hepatic fibrotic microenvironment with emerging nanotherapeutics: a comprehensive review

Zhao, X.-T., Amevor, F. K., Xue, X.-Y., Wang, C., Cui, Z., Dai, S.-H., Peng, C., & Li, Y.-X. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01876-5 · Cited by 40 · see citing works

Rising Influence of Nanotechnology in Addressing Oxidative Stress-Related Liver Disorders

Padmanaban, S., Pully, D., Samrot, A. V., Gosu, V., Sadasivam, N., Park, I., Radhakrishnan, K., & Kim, D. (2023) · Antioxidants · doi:10.3390/antiox12071405 · Cited by 37 · see citing works

Inhaled nanoparticles for treating idiopathic pulmonary fibrosis by inhibiting honeycomb cyst and alveoli interstitium remodeling

Han, M., Ling, T., Huang, B., Li, X., Fang, Y., Qi, L., Duan, B., Yao, Y., He, Y., Xing, L., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.01.032 · Cited by 37 · see citing works

Remodeling of imbalanced extracellular matrix homeostasis for reversal of pancreatic fibrosis

Qi, L., Han, H., Han, M.-M., Sun, Y., Xing, L., Jiang, H.-L., Pandol, S. J., & Li, L. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2022.121945 · Cited by 36 · see citing works

Effect of biophysical properties of tumor extracellular matrix on intratumoral fate of nanoparticles: Implications on the design of nanomedicine

Tian, Y., Cheng, T., Sun, F., Zhou, Y., Yuan, C., Guo, Z., & Wang, Z. (2024) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2024.103124 · Cited by 36 · see citing works

On-demand targeting nanotheranostics with stimuli-responsive releasing property to improve delivery efficiency to cancer

Lu, H., Xu, J., Yang, J., Wang, Z., Xu, P., Hao, Q., Luo, W., Li, S., Li, Z., Xue, X., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121852 · Cited by 36 · see citing works

Fucoidan: Biological Activity in Liver Diseases

Li, J., Guo, C., & Wu, J. (2020) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x20500809 · Cited by 35 · see citing works

Polymeric nanomedicines for the treatment of hepatic diseases

Luo, F., Yu, Y. F., Li, M., Chen, Y., Zhang, P., Xiao, C., & Lv, G. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01708-y · Cited by 35 · see citing works

Progress in drug delivery system for fibrosis therapy

Xing, L., Chang, X. Y., Shen, L., Zhang, C., Fan, Y., Cho, C., Zhang, Z., & Jiang, H. (2020) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2020.06.005 · Cited by 34 · see citing works

Selective inhibition of glycolysis in hepatic stellate cells and suppression of liver fibrogenesis with vitamin A-derivative decorated camptothecin micelles

Li, X., Wang, X., Jiao, Q., Shao, Y., Luo, R., Zhang, J., Zheng, X., Zhou, S., & Chen, Y. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.07.035 · Cited by 34 · see citing works

Liver fibrosis: pathological features, clinical treatment and application of therapeutic nanoagents

Chen, L., Guo, W., Mao, C., Shen, J., & Wan, M. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02790b · Cited by 33 · see citing works

Polymer–drug and polymer–protein conjugated nanocarriers: Design, drug delivery, imaging, therapy, and clinical applications

Guo, H., & Mi, P. (2024) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1988 · Cited by 33 · see citing works

Liver cirrhosis: molecular mechanisms and therapeutic interventions

Dong, Z., Wang, Y., & Jin, W. (2024) · MedComm · doi:10.1002/mco2.721 · Cited by 31 · see citing works

Combination therapy based on targeted nano drug co-delivery systems for liver fibrosis treatment: a review

Zhou, L., Li, Y., Liang, Q., Liu, J., & Liu, Y. (2022) · Journal of drug targeting · doi:10.1080/1061186x.2022.2044485 · Cited by 31 · see citing works

Biological Hyperthermia-Inducing Nanoparticles for Specific Remodeling of the Extracellular Matrix Microenvironment Enhance Pro-Apoptotic Therapy in Fibrosis

Zhang, J., Ji, K., Ning, Y., Sun, L., Fan, M., Shu, C., Zhang, Z., Tu, T., Cao, J., Gao, F., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c12831 · Cited by 30 · see citing works

Recent advances in polymeric nanoparticles for the treatment of hepatic diseases

Gao, F., Feng, X., & Li, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1528752 · Cited by 30 · see citing works

Understanding the Potential Role of Nanotechnology in Liver Fibrosis: A Paradigm in Therapeutics

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Impact of Reverse Micelle Loaded Lipid Nanocapsules on the Delivery of Gallic Acid into Activated Hepatic Stellate Cells: A Promising Therapeutic Approach for Hepatic Fibrosis

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