Brain-targeted delivery shuttled by black phosphorus nanostructure to treat Parkinson's disease
Abstract
The treatment of Parkinson's disease (PD) is hampered by the blood-brain barrier (BBB). As such, there is an urgent need for the development of a novel nanoplatform capable of penetrating the BBB in order to effectively treat PD. In the present study, we utilized black phosphorus nanosheets (BP) containing the brain-targeting ligand lactoferrin (Lf) and loaded with Paeoniflorin (Pae) to obtain Lf-BP-Pae. Through an effective photo-thermal effect, these Lf-BP-Pae particles were capable of traversing the BBB and effectively treating PD in a targeted manner. Importantly, this BP-based nanoplatform was capable of achieving satisfactory biocompatibility and biosafety with excellent anti-Parkinsonian efficacy, making it ideal for clinical applications.
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A black phosphorus-based delivery system with lactoferrin and Paeoniflorin-loaded black phosphorus nanosheets showed elevated BBB permeability due to lactoferrin-mediated BBB transcytosis and photothermal effects.
“Elevated BBB permeability of the system was observed due to a combination of lactoferrin-mediated BBB transcytosis and photothermal effects.”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [371]
Cites
Protein transmission in neurodegenerative disease
Peng, C., Trojanowski, J. Q., & Lee, V. M.-Y. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0333-7 · Cited by 625 · see citing works
Nanotechnology—novel therapeutics for CNS disorders
Srikanth, M., & Kessler, J. A. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.76 · Cited by 198 · see citing works
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The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906 · see citing works
“371 Elevated BBB permeability of the system was observed due to a combination of lactoferrin-mediated BBB transcytosis and photothermal effects.”
BackgroundSelf-citation
- Authors
- Xiong, S., Li, Z., Liu, Y., Wang, Q., Luo, J., Chen, X., Xie, Z., Zhang, Y., Zhang, H., & Chen, T.
- Affiliations
- Guangzhou University of Chinese Medicine (CN)
- Shenzhen University (CN)
- University of Macau (MO)
- Corresponding author
- Zhang, Han
- Chen, Tongkai
- ORCID
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 260
- Pages
- 120339
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W3080479888
- Cited by
- 113
- References
- 2
- Citations by year
- 2026: 9 · 2025: 22 · 2024: 22 · 2023: 19 · 2022: 17 · 2021: 22 · 2020: 2
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Research Foundation (2019B1515120043, A2019027)
- Guangdong Provincial Natural Science Foundation (2018A030310623)
- University of Macau (MYRG2019-00121)
- ICMS (MYRG2018-00207)
- Instrumental Analysis Center of Shenzhen University
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- Parkinson's disease, black phosphorus nanosheets, blood-brain barrier, brain drug delivery, lactoferrin, paeoniflorin, photothermal effect, nanoplatforms, neuroprotection, biocompatibility
- MeSH terms
- Blood-Brain Barrier, Brain, Humans, Lactoferrin, Parkinson Disease, Phosphorus, Drug Delivery Systems, Nanostructures, Nanoparticles
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