Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

The role of a novel copper complex in overcoming doxorubicin resistance in Ehrlich ascites carcinoma cells in vivo

Majumder, S., Dutta, P., Mookerjee, A., & Choudhuri, S. K. (2005) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.10.044 · Cited by 54

Sanguinarine enhances cisplatin sensitivity via glutathione depletion in cisplatin‐resistant ovarian cancer (A2780) cells

Sarkhosh‐Inanlou, R., Molaparast, M., Mohammadzadeh, A., & Shafiei‐Irannejad, V. (2019) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13621 · Cited by 53

Effect of 3-bromopyruvate acid on the redox equilibrium in non-invasive MCF-7 and invasive MDA-MB-231 breast cancer cells

Kwiatkowska, E., Wojtala, M., Gajewska, A., Soszyński, M., Bartosz, G., & Sadowska‐Bartosz, I. (2015) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-015-9637-5 · Cited by 52

Dual Receptor-Targeted and Redox-Sensitive Polymeric Micelles Self-Assembled from a Folic Acid-Hyaluronic Acid-SS-Vitamin E Succinate Polymer for Precise Cancer Therapy

Yang, Y., Li, Y., Chen, K., Zhang, L., Qiao, S., Tan, G., Chen, F., & Pan, W. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s249205 · Cited by 52

Redox-sensitive micelles based on retinoic acid modified chitosan conjugate for intracellular drug delivery and smart drug release in cancer therapy

Luo, T., Han, J., Zhao, F., Pan, X., Tian, B., Ding, X.-J., & Zhang, J. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.03.064 · Cited by 51

Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux

Lorendeau, D., Dury, L., Genoux‐Bastide, E., Lecerf-Schmidt, F., Simões‐Pires, C. A., Carrupt, P., Terreux, R., Magnard, S., Pietro, A. D., Boumendjel, A., et al. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.05.017 · Cited by 50

Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine Sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance

Cruz, A., Mota, P., Ramos, C., Pires, R. F., Mendes, C., Silva, J., Nunes, S. C., Bonifácio, V. D. B., & Serpa, J. (2020) · Antioxidants · doi:10.3390/antiox9020133 · Cited by 50

H 2 O 2 -activated oxidative stress amplifier capable of GSH scavenging for enhancing tumor photodynamic therapy

Liu, Y., Zhou, Z., Liu, Y., Li, Y., Huang, X., Qian, C., & Sun, M. (2019) · Biomaterials Science · doi:10.1039/c9bm01354g · Cited by 50

Glutathione S‑transferase isozyme alpha 1 is predominantly involved in the cisplatin resistance of common types of solid cancer

Zou, M., Hu, X., Xu, B., Tong, T., Jing, Y., Xi, L., Zhou, W., Lu, J., Wang, X., Yang, X., et al. (2018) · Oncology Reports · doi:10.3892/or.2018.6861 · Cited by 49

The role of GSH efflux in staurosporine-induced apoptosis in colonic epithelial cells

Circu, M. L., Stringer, S., Rhoads, C. A., Moyer, M. P., & Aw, T. Y. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.09.011 · Cited by 48

The effects of buthionine sulfoximine on the proliferation and apoptosis of biliary tract cancer cells induced by cisplatin and gemcitabine

Li, Q., Yin, X., Wang, W. T., Zhan, M., Zhao, B., Hou, Z., & Wang, J. (2015) · Oncology Letters · doi:10.3892/ol.2015.3879 · Cited by 44

Redox-sensitive, cholesterol-bearing PEGylated poly(propylene imine)-based dendrimersomes for drug and gene delivery to cancer cells

Laskar, P., Somani, S., Altwaijry, N., Mullin, M., Bowering, D., Warzecha, M., Keating, P., Tate, R. J., Leung, H. Y., & Dufès, C. (2018) · Nanoscale · doi:10.1039/c8nr08141g · Cited by 44

Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death

Zheng, W., Zhou, C.-Y., Zhu, X., Wang, X., Li, Z.-Y., Chen, X.-C., Chen, F., Che, X., & Xie, X. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.111 · Cited by 43

3-Bromopyruvate induces rapid human prostate cancer cell death by affecting cell energy metabolism, GSH pool and the glyoxalase system

Valenti, D., Vacca, R. A., & Lidia de, B. A. R. I. (2015) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-015-9631-y · Cited by 42

Verapamil Revisited

Prisant, L. M. (2001) · Heart Disease · doi:10.1097/00132580-200101000-00008 · Cited by 40

Association of Glutathione Level and Cytotoxicity of Gold Nanoparticles in Lung Cancer Cells

Zhao, Y., Gu, X., Ma, H., He, X., Liu, M., & Ding, Y. (2011) · The Journal of Physical Chemistry C · doi:10.1021/jp2025413 · Cited by 39

The Anticancer Drug 3-Bromopyruvate Induces DNA Damage Potentially Through Reactive Oxygen Species in Yeast and in Human Cancer Cells

Cal, M., Matyjaszczyk, I., Litwin, I., Augustyniak, D., Ogórek, R., Ko, Y. H., & Ułaszewski, S. (2020) · Cells · doi:10.3390/cells9051161 · Cited by 37

Enhancement of ultralow-intensity NIR light-triggered photodynamic therapy based on exo- and endogenous synergistic effects through combined glutathione-depletion chemotherapy

Shi, J., Wang, T.-R., You, Y., Akhtar, M. L., Liu, Z., Han, F., Yu, H., & Wang, Y. (2019) · Nanoscale · doi:10.1039/c9nr03052b · Cited by 37

The Xc− inhibitor sulfasalazine improves the anti-cancer effect of pharmacological vitamin C in prostate cancer cells via a glutathione-dependent mechanism

Zheng, Z., Luo, G., Shi, X., Long, Y., Shen, W., Li, Z., & Zhang, X. (2019) · Cellular Oncology · doi:10.1007/s13402-019-00474-8 · Cited by 36

Glutathione reductase-mediated thiol oxidative stress suppresses metastasis of murine melanoma cells

Li, X., Wu, J., Zhang, X., & Chen, W. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.07.025 · Cited by 36

Ferrocene-embedded flavonoids targeting the Achilles heel of multidrug-resistant cancer cells through collateral sensitivity

Pérès, B., Nasr, R., Zarioh, M., Lecerf-Schmidt, F., Pietro, A. D., Baubichon-Cortay, H., & Boumendjel, A. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.02.064 · Cited by 35

Lenvatinib-zinc phthalocyanine conjugates as potential agents for enhancing synergistic therapy of multidrug-resistant cancer by glutathione depletion

Wei, G., Huang, L., Jiang, Y., Shen, Y., Huang, Z., Huang, Y., Sun, X., & Zhao, C. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.02.065 · Cited by 35

A hydrogen peroxide-activated Cu(II) pro-ionophore strategy for modifying naphthazarin as a promising anticancer agent with high selectivity for generating ROS in HepG2 cells over in L02 cells

Bao, X., Wang, Q., Ren, X., Dai, F., & Zhou, B. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.12.001 · Cited by 35

Bone-targeted oxidative stress nanoamplifier for synergetic chemo/chemodynamic therapy of bone metastases through increasing generation and reducing elimination of ROS

Huang, Z., Huang, Y., Chen, M., Chen, J., Zeng, Z., Xu, X., Huang, B., Luo, Y., Xiao, Z., Ding, Y., et al. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.125667 · Cited by 35

Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1

Dury, L., Nasr, R., Lorendeau, D., Comsa, E., Wong, I. L. K., Zhu, X., Chan, K., Chan, T. H., Chow, L. M. C., Falson, P., et al. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.10.013 · Cited by 34

Two-stage activated nano-truck enhanced specific aggregation and deep delivery for synergistic tumor ablation

Zheng, Z., Chen, Q., Rong, S., Dai, R., Jia, Z., Peng, X., & Zhang, R. (2020) · Nanoscale · doi:10.1039/d0nr03661g · Cited by 34

Targeting redox vulnerability of cancer cells by prooxidative intervention of a glutathione-activated Cu(II) pro-ionophore: Hitting three birds with one stone

Bao, X., Dai, F., Li, X., & Zhou, B. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.06.021 · Cited by 33

Enhanced photodynamic therapy based on an amphiphilic branched copolymer with pendant vinyl groups for simultaneous GSH depletion and Ce6 release

Cao, H., Zhong, S., Wang, Q., Chen, C., Tian, J. H., & Zhang, W. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb02120e · Cited by 32

Identification of capsazepine as a novel inhibitor of system xc− and cancer-induced bone pain

Fazzari, J., Balenko, M. D., Zacal, N., & Singh, G. (2017) · Journal of Pain Research · doi:10.2147/jpr.s125045 · Cited by 29

Cytotoxicity of luteolin in primary rat hepatocytes: the role of CYP3A‐mediated ortho‐benzoquinone metabolite formation and glutathione depletion

Shi, F., Zhao, P. F., Li, X., Pan, H., Ma, S., & Ding, L. (2015) · Journal of Applied Toxicology · doi:10.1002/jat.3106 · Cited by 29

Exogenous glutathione improves intracellular glutathione synthesis via the γ‐glutamyl cycle in bovine zygotes and cleavage embryos

Feng, L., Cui, L., Yu, D., Hao, H., Liu, Y., Zhao, X., Pang, Y., Zhu, H., & Du, W. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27497 · Cited by 29

Involvement of Glutathione Depletion in Selective Cytotoxicity of Oridonin to p53-Mutant Esophageal Squamous Carcinoma Cells

Li, Y., Li, N., Shi, J., Ahmed, T., Liu, H., Guo, J., Tang, W., Guo, Y., & Zhang, Q. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01525 · Cited by 29

Boosted photocatalytic activity induced NAMPT-Regulating therapy based on elemental bismuth-humic acids heterojunction for inhibiting tumor proliferation/migration/inflammation

Song, Y., Yang, L., Xu, M., Lu, Q., Li, W., Ren, C., Liu, P., Wang, Y., Zhu, Y., Tan, F., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120140 · Cited by 29

Inhibiting Glutathione Metabolism in Lung Lining Fluid as a Strategy to Augment Antioxidant Defense

Joyce-Brady, M. F., & Hiratake, J. (2011) · Current Enzyme Inhibition · doi:10.2174/157340811796575308 · Cited by 28

Iodination of verapamil for a stronger induction of death, through GSH efflux, of cancer cells overexpressing MRP1

Barattin, R., Perrotton, T., Trompier, D., Lorendeau, D., Pietro, A. D., d′Hardemare, A. D. M., & Baubichon-Cortay, H. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.07.031 · Cited by 25

A ROS responsive nanomedicine with enhanced photodynamic therapy via dual mechanisms: GSH depletion and biosynthesis inhibition

Hu, J., Wang, T., Zhou, L., & Wei, S. (2020) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2020.111955 · Cited by 25

Tumor microenvironment responsive mesoporous silica nanoparticles for dual delivery of doxorubicin and chemodynamic therapy (CDT) agent

Zhang, Y., Eltayeb, O., Meng, Y., Zhang, G., Zhang, Y., Shuang, S., & Dong, C. (2020) · New Journal of Chemistry · doi:10.1039/c9nj05427h · Cited by 25

Consumption of redox energy by glutathione metabolism contributes to hypoxia/ reoxygenation-induced injury in astrocytes

Pr, M., Kropf, S., Wiswedel, I., Augustin, W., & Schild, L. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-9098-y · Cited by 24

Relation between the ability of some compounds to modulate the MRP1-mediated efflux of glutathione and to inhibit the MRPl-mediated efflux of daunorubicin

Salerno, M., Loechariyakul, P., Saengkhae, C., & Garnier‐Suillerot, A. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.08.010 · Cited by 22

Inhibiting Radiative Transition-Mediated Multifunctional Polymeric Nanoplatforms for Highly Efficient Tumor Phototherapeutics

Zhu, Y., Chen, C., Yang, G., Wu, Q., Tian, J. H., Hao, E., Cao, H., Gao, Y., & Zhang, W. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c12756 · Cited by 22

Increased Skin Papilloma Formation in Mice Lacking Glutathione Transferase GSTP

Henderson, C. J., Ritchie, K. J., McLaren, A. W., Chakravarty, P., & Wolf, C. R. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0882 · Cited by 21

Purine Nucleoside Analog - Sulfinosine Modulates Diverse Mechanisms of Cancer Progression in Multi-Drug Resistant Cancer Cell Lines

Dačević, M., Isaković, A., Podolski-Renić, A., Isakovic, A. M., Stanković, T., Milosevic, Z. C., Rakić, L., Ruždijić, S., & Pešić, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054044 · Cited by 21

Histone methyltransferase G9a inhibitor-loaded redox-responsive nanoparticles for pancreatic ductal adenocarcinoma therapy

Wang, J., Wang, L., Li, S.-J., Tong, T., Wang, L., Huang, C., Xu, Q., Huang, X., Li, J., Wu, J., et al. (2020) · Nanoscale · doi:10.1039/d0nr03138k · Cited by 20

Chemosensitization effect of cerium oxide nanosheets by suppressing drug detoxification and efflux

Wu, G., Zhang, Z., Chen, X., Yu, Q., Ma, X., & Liu, L. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.10.013 · Cited by 19

Ryanodine Receptor Channel-Dependent Glutathione Transport in the Sarcoplasmic Reticulum of Skeletal Muscle

Csala, M., Fulceri, R., Mandl, J., Benedetti, A., & Bánhegyi, G. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5648 · Cited by 18

Lowering glutathione level by buthionine sulfoximine enhances in vivo photodynamic therapy using chlorin e6-loaded nanoparticles

Yoo, J., Jang, S.-Y., Park, C., Lee, D., Kwon, S., & Koo, H. (2020) · Dyes and Pigments · doi:10.1016/j.dyepig.2020.108207 · Cited by 18

Inhibition of reductase systems by 2-AAPA modulates peroxiredoxin oxidation and mitochondrial function in A172 glioblastoma cells

de Souza, L. F., Schmitz, A. E., da Silva, L. C. S., de Oliveira, K. A., Nedel, C. B., Tasca, C. I., Bem, A. F. D., Farina, M., & Dafré, A. L. (2017) · Toxicology in Vitro · doi:10.1016/j.tiv.2017.04.028 · Cited by 15

A Janus upconverting nanoplatform with biodegradability for glutathione depletion, near-infrared light induced photodynamic therapy and accelerated excretion

Zhou, H., Li, Q., Cheng, X., Zhang, C., Sun, J., Du, L., Cao, J., Liu, Y., & Huang, P. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01357a · Cited by 15

Synthesis and characterization of lysozyme-conjugated Ag.ZnO@HA nanocomposite: A redox and pH-responsive antimicrobial agent with photocatalytic activity

Lotfali, H., & Meshkini, A. (2021) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2021.102418 · Cited by 13

Redox-responsive chemosensitive polyspermine delivers ursolic acid targeting to human breast tumor cells: The depletion of intracellular GSH contents arouses chemosensitizing effects

Ji, X., Tang, Q., Pang, P., Wu, J., Kirk, T. B., Xu, J., Ma, D., & Xue, W. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.06.029 · Cited by 11

Self‐Assemble Polymeric Nanoparticle with GSH Exhaustion for SPECT Imaging–Guided Enhanced Radioisotope Therapy

Tao, Y., Ren, P., Yi, X., Zhou, H., Xiong, S., Ge, F., Chen, L., & Yang, K. (2019) · Particle & Particle Systems Characterization · doi:10.1002/ppsc.201900018 · Cited by 9

Iron Homeostasis and Ferroptosis in Human Diseases: Mechanisms and Therapeutic Prospects

Ru, Q., Li, Y., Chen, L., Wu, Y., Min, J., & Wang, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01969-z · Cited by 724

Cellular zinc metabolism and zinc signaling: From biological functions to diseases and therapeutic targets

Chen, B., Yu, P., Chan, W. N., Xie, F., Zhang, Y., Liang, L., Leung, K. T., Lo, K. W., Yu, J., Tse, G. M. K., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01679-y · Cited by 420

Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy

Zheng, P., Zhou, C., Lu, L., Liu, B., & Ding, Y. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02485-0 · Cited by 375

Ferroptosis Detection: From Approaches to Applications

Zeng, F., Nijiati, S., Tang, L., Ye, J., Zhou, Z., & Chen, X. S. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202300379 · Cited by 324

A Hollow Amorphous Bimetal Organic Framework for Synergistic Cuproptosis/Ferroptosis/Apoptosis Anticancer Therapy via Disrupting Intracellular Redox Homeostasis and Copper/Iron Metabolisms

Xu, W., Qian, J., Hou, G., Wang, T., Wang, J., Wang, Y., Yang, L., Cui, X., & Suo, A. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202205013 · Cited by 271

Nanotherapeutics induced redox resetting of oxidative and nitrosative stress: targeting glutathione-depletion in cancer

Dangi, K., Kumar, V., Mittal, D., Yadav, P., Malik, M., & Verma, A. K. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2489918 · Cited by 13

Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Xiong, Y., Xiao, C., Li, Z., & Yang, X. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00718h · Cited by 702

Glutathione Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy

Roy, N., & Paira, P. (2024) · ACS Omega · doi:10.1021/acsomega.3c08890 · Cited by 60

Harnessing ROS Amplification and GSH Depletion Using a Carrier‐Free Nanodrug to Enhance Ferroptosis‐Based Cancer Therapy

Zhang, H., Shan, G., Liu, M., Sun, Q., Yang, T., Peng, R., Li, X., Mei, Y., He, X., & Qiao, L. (2024) · Small · doi:10.1002/smll.202409250 · Cited by 33

Novel strategies of glutathione depletion in photodynamic and chemodynamic therapy: A review

Wolny, D., Stojko, M., & Zajdel, A. (2024) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/191025 · Cited by 11