The DOI matches its Crossref record; 251 of the 254 references it cites were found in a registry or an index.
Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy
Abstract
Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) and detoxify xenobiotics, which make it a potential target for cancer therapy. Plenty of studies have shown that loss of intracellular GSH makes cancer cells more susceptible to oxidative stress and chemotherapeutic agents. GSH depletion has been proved to improve the therapeutic efficacy of ROS-based therapy (photodynamic therapy, sonodynamic therapy, and chemodynamic therapy), ferroptosis, and chemotherapy. In this review, various strategies for GSH depletion used in cancer therapy are comprehensively summarized and discussed. First, the functions of GSH in cancer cells are analyzed to elucidate the necessity of GSH depletion in cancer therapy. Then, the synthesis and metabolism of GSH are briefly introduced to bring up some crucial targets for GSH modulation. Finally, different approaches to GSH depletion in the literature are classified and discussed in detail according to their mechanisms. Particularly, functional materials with GSH-consuming ability based on nanotechnology are elaborated due to their unique advantages and potentials. This review presents the ingenious application of GSH-depleting strategy in cancer therapy for improving the outcomes of various therapeutic regimens, which may provide useful guidance for designing intelligent drug delivery system.
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“Furthermore, hypoxia and high glutathione (GSH) concentrations in the tumor microenvironment (TME) greatly limit the efficacy of SDT [24–26].”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [25]
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1 retracted
Cai, X., Xie, Z., Ding, B., Shao, S., Liang, S., Pang, M., & Lin, J. (2019) · Advanced Science · doi:10.1002/advs.201900848 · Cited by 209
RetractedFerroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
ROS function in redox signaling and oxidative stress
Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931
Oxidative stress: oxidants and antioxidants
Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577
Hoyle, C. E., & Bowman, C. N. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200903924 · Cited by 4,201
Glutathione Metabolism and Its Implications for Health
Wu, G., Lupton, J. R., Turner, N. D., Fang, Y.-Z., & Yang, S. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.3.489 · Cited by 3,842
Association of reactive oxygen species levels and radioresistance in cancer stem cells
Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555
Functional Nanomaterials for Phototherapies of Cancer
Cheng, L., Wang, C., Feng, L., Yang, K., & Liu, Z. (2014) · Chemical Reviews · doi:10.1021/cr400532z · Cited by 2,438
Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species
He, L., He, T., Farrar, S., Ji, L., Liu, T., & Ma, X. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485089 · Cited by 2,207
Lu, S. C.-L. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.09.008 · Cited by 2,192
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Iron Homeostasis and Ferroptosis in Human Diseases: Mechanisms and Therapeutic Prospects
Ru, Q., Li, Y., Chen, L., Wu, Y., Min, J., & Wang, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01969-z · Cited by 724
Chen, B., Yu, P., Chan, W. N., Xie, F., Zhang, Y., Liang, L., Leung, K. T., Lo, K. W., Yu, J., Tse, G. M. K., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01679-y · Cited by 420
Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy
Zheng, P., Zhou, C., Lu, L., Liu, B., & Ding, Y. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02485-0 · Cited by 375
Ferroptosis Detection: From Approaches to Applications
Zeng, F., Nijiati, S., Tang, L., Ye, J., Zhou, Z., & Chen, X. S. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202300379 · Cited by 324
Xu, W., Qian, J., Hou, G., Wang, T., Wang, J., Wang, Y., Yang, L., Cui, X., & Suo, A. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202205013 · Cited by 271
Metadata
- Authors
- Niu, B., Liao, K., Zhou, Y., Wen, T., Quan, G., Pan, X., & Wu, C.
- Affiliations
- Sun Yat-sen University (CN)
- Jinan University (CN)
- Corresponding author
- Pan, Xin
- Wu, Chuanbin
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2021-10
- Volume
- 277
- Pages
- 121110
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W3198675921
- Cited by
- 1,168
- References
- 254
- Citations by year
- 2026: 168 · 2025: 353 · 2024: 330 · 2023: 201 · 2022: 110 · 2021: 6
- FWCI
- 13.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- glutathione depletion, cancer therapy, reactive oxygen species, ferroptosis, photodynamic therapy, sonodynamic therapy, chemodynamic therapy, oxidative stress, glutathione metabolism, glutathione synthesis, drug delivery systems, chemotherapy enhancement
- MeSH terms
- Ferroptosis, Antineoplastic Agents, Glutathione, Neoplasms, Photochemotherapy, Reactive Oxygen Species
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