The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing
Open accessAbstract
Electrical stimulation can facilitate wound healing with high efficiency and limited side effects. However, current electrical stimulation devices have poor conformability with wounds due to their bulky nature and the rigidity of electrodes utilized. Here, a flexible electrical patch (ePatch) made with conductive hydrogel as electrodes to improve wound management was reported. The conductive hydrogel was synthesized using silver nanowire (AgNW) and methacrylated alginate (MAA), with the former chosen as the electrode material considering its antibacterial properties, and the latter used due to its clinical suitability in wound healing. The composition of the hydrogel was optimized to enable printing on medical-grade patches for personalized wound treatment. The ePatch was shown to promote re-epithelization, enhance angiogenesis, mediate immune response, and prevent infection development in the wound microenvironment. In vitro studies indicated an elevated secretion of growth factors with enhanced cell proliferation and migration ability in response to electrical stimulation. An in vivo study in the Sprague-Dawley rat model revealed a rapid wound closure within 7 days compared to 20 days of usual healing process in rodents.
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Cites
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro
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Lab-on-Skin: A Review of Flexible and Stretchable Electronics for Wearable Health Monitoring
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Roll-to-Roll Gravure Printed Electrochemical Sensors for Wearable and Medical Devices
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Effective Wound Healing Enabled by Discrete Alternative Electric Fields from Wearable Nanogenerators
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Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing
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Cited by
Hydrogels for Flexible Electronics
Zhang, Y., Tan, Y., Lao, J., Gao, H., & Yu, J. (2023) · ACS Nano · doi:10.1021/acsnano.3c02897 · Cited by 291
Stimuli‐Responsive Hydrogels for Antibacterial Applications
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Chen, Y., Zhang, Y., Chang, L., Sun, W., Duan, W., & Qin, J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125644 · Cited by 35
Self-citationMultifunctional Magnetic Nanoparticles for Dynamic Imaging and Therapy
Ko, M. J., Hong, H., Choi, H., Kang, H., & Kim, D. (2022) · Advanced NanoBiomed Research · doi:10.1002/anbr.202200053 · Cited by 29
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Metadata
- Authors
- Wang, C., Jiang, X., Kim, H.-J., Zhang, S., Zhou, X., Chen, Y., Ling, H., Xue, Y., Chen, Z., Qu, M., Ren, L., Zhu, J., Libanori, A., Zhu, Y., Kang, H., Ahadian, S., Dokmeci, M. R., Servati, P., He, X., Gu, Z., Sun, W., & Khademhosseini, A.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 285
- Pages
- 121479
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W4223972061
- Cited by
- 218
- References
- 6
- FWCI
- 16.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, C., Jiang, X., Kim, H.-J., Zhang, S., Zhou, X., Chen, Y., Ling, H., Xue, Y., Chen, Z., Qu, M., Ren, L., Zhu, J., Libanori, A., Zhu, Y., Kang, H., Ahadian, S., Dokmeci, M. R., Servati, P., He, X., . . . Khademhosseini, A. (2022). Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing. Biomaterials. https://doi.org/10.1016/j.biomaterials.2022.121479
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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