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Bi2WO6@Cu2O-GOx bio-heterojunction spray for accelerating chronic diabetic wound repairment with bilaterally enhanced sono-catalysis and glycolytic inhibition antisepsis
Abstract
Chronic diabetic wound poses a pressing global healthcare challenge, necessitating an approach to address issues such as pathogenic bacteria elimination, blood sugar regulation, and angiogenesis stimulation. Herein, we engineered a Bi 2 WO 6@Cu 2 O-GOx bio-heterojunction (BWCG bio-HJ) with exceptional cascade catalytic performance and impressive sonosensitivity to remodel the wound microenvironment and expedite the diabetic wound healing. Specifically, the Z-scheme junctions of Bi 2 WO 6@Cu 2 O significantly augmented carrier separation dynamics, leading to the highly efficient generation of reactive oxygen species (ROS) upon US irradiations. Furthermore, glucose oxidase (GOx) grafted on the Bi 2 WO 6@Cu 2 O surface facilitated the conversion of glucose into H 2 O 2 and glucuronic acid, providing a rich supply for Cu+-mediated Fenton-like reactions. The robust oxidation effect disrupted the bacteria's phosphotransferase system (PTS), hindering glucose uptake, glycolysis, and energy metabolism, ultimately inducing bacterial death and reshaping the diabetic wound microenvironment. The BWCG bio-HJ was formulated as an antibacterial spray for chronic diabetic wound repair. Extensive in vitro and in vivo experiments confirmed that the BWCG bio-HJ spray could eliminate pathogenic bacteria, consume local blood sugar, and promote angiogenesis, collagen deposition, and epithelialization, thereby accelerating the diabetic wound healing process. This bio-heterojunction spray comprehensively addressed the principal pathological factors associated with diabetic wounds, offering a promising strategy for combatting stubborn infections.
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“It efficiently catalyzes the in situ conversion of Glu into hydrogen peroxide (H2O2) and gluconic acid15.”
From Microenvironment-responsive multifunctional enzyme-linked hydrogel for diabetic bone defect regeneration. (2025) · cites this paper as [15]
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Metadata
- Authors
- Wang, Y., Chang, F., Li, Y., Wang, F., Li, C., Li, H., & Jiang, Y.
- Affiliations
- Second Hospital of Shandong University (CN)
- Shandong University (CN)
- Corresponding author
- Jiang, Yanyan
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2025-06
- Volume
- 317
- Pages
- 123046
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W4405738584
- Cited by
- 26
- References
- 34
- Citations by year
- 2026: 17 · 2025: 9
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (52101287)
- Fundamental Research Funds for the Central Universities (2022JC002, 2022JC020)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Advanced Photocatalysis Techniques
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Keywords
- Z-scheme heterojunction, glucose oxidase, glycolysis inhibition, Fenton-like reaction, reactive oxygen species, wound microenvironment, angiogenesis, blood glucose regulation, wound infection
- MeSH terms
- Animals, Anti-Bacterial Agents, Catalysis, Copper, Diabetes Mellitus, Experimental, Glucose Oxidase, Glycolysis, Humans, Hydrogen Peroxide, Male, Wound Healing, Reactive Oxygen Species, Mice
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