Cited by 297Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismNitric Oxide and Endothelin Effects

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Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway

Geng, Jin, Yang, Chenchen, Wang, Bingjian, Zhang, Xiwen, Hu, Tingting, Gu, Yang, Li, Ju·2018·Biomedicine & Pharmacotherapy

DOI 10.1016/j.biopha.2017.11.016

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Abstract

Background Many studies have identified trimethylamine N-oxide (TMAO) as a new risk factor of cardiovascular diseases. It has been suggested that TMAO promotes atherosclerosis development. However, the underlying mechanism is still unclear.Methods Apoe-/- mice were fed a high-fat diet and given water with or without TMAO for 8-week. Histological and immunohistological analyses were used to evaluate the atherogenic effect of TMAO in vivo. We also employed peritoneal elicited macrophages and RAW264.7 to assess the role of MAPK/JNK pathway in TMAO-induced formation of foam cells.Results TMAO significantly promoted plaque progression in apoe-/- mice fed with high-fat diet for 8 weeks. Besides, macrophage recruitment, CD36 and proinflammatory cytokine expressions were enhanced by TMAO in plaque lesions. In vitro, TMAO increased the macrophage migration and the expression of TNF-α, IL-6 and ICAM1. In addition, CD36 expression and foam cell formation induced by ox-LDL were also enhanced by TMAO, which could be attenuated by siRNA-mediated knockdown of CD36. We additionally used MAPK inhibitor (SB230580) and JNK inhibitor (SP600125) to assess the MAPK/JNK pathway in TMAO-induced CD36 expression. Western blotting showed that both SB230580 and SP600125 could reduce the expression of CD36 induced by ox-LDL and TMAO. Moreover, SB230580 and SP600125 could also reduce the formation of foam cells.Conclusions TMAO promotes the atherosclerosis in vivo and in vitro.CD36/MAPK/JNK pathway may play a crucial role in TMAO-induced formation of foam cells.

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Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386
Progress and challenges in translating the biology of atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2011) · Nature · doi:10.1038/nature10146 · Cited by 4,010
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,400
Mechanisms of plaque formation and rupture
Bentzon, J. F., Otsuka, F., Virmani, R., & Falk, E. (2014) · Circulation Research · doi:10.1161/circresaha.114.302721 · Cited by 2,391
Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
Zhu, W., Gregory, J. C., Org, E., Buffa, J. A., Gupta, N., Wang, Z., Li, L., Fu, X., Wu, Y., Mehrabian, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.011 · Cited by 1,968
Red and Processed Meat Consumption and Risk of Incident Coronary Heart Disease, Stroke, and Diabetes Mellitus: A Systematic Review and Meta-Analysis
Micha, R., Wallace, S. K., & Mozaffarian, D. (2010) · Circulation · doi:10.1161/circulationaha.109.924977 · Cited by 1,244
Gut Microbiota-Dependent Trimethylamine N -Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease
Tang, W. H. W., Wang, Z., Kennedy, D. J., Wu, Y., Buffa, J. A., Agatisa-Boyle, B., Li, X. S., Levison, B. S., & Hazen, S. L. (2015) · Circulation Research · doi:10.1161/circresaha.116.305360 · Cited by 1,223
Senescent intimal foam cells are deleterious at all stages of atherosclerosis
Childs, B. G., Baker, D. J., Wijshake, T., Conover, C. A., Campisi, J., & van Deursen, J. M. (2016) · Science · doi:10.1126/science.aaf6659 · Cited by 1,195
Scavenger Receptors Class A-I/II and CD36 Are the Principal Receptors Responsible for the Uptake of Modified Low Density Lipoprotein Leading to Lipid Loading in Macrophages*
Kunjathoor, V., Febbraio, M., Podrez, E., Moore, K., Andersson, L., Koehn, S. L., Rhee, J. S., Silverstein, R., Hoff, H., & Freeman, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209649200 · Cited by 1,064

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Authors: Geng, J., Yang, C., Wang, B., Zhang, X., Hu, T., Gu, Y., & Li, J.
Affiliations: Huaian First People’s Hospital (CN)
Corresponding author: Li, Ju
ORCID: Geng, Jin
Yang, Chenchen
Zhang, Xiwen
Hu, Tingting
Gu, Yang
Venue: Biomedicine & Pharmacotherapy
Publisher: Elsevier BV
Published: 2018-01
Volume: 97
Pages: 941-947
ISSN: 0753-3322 (ISSN-L)
DOI: 10.1016/j.biopha.2017.11.016
OpenAlex: W2767697969
Cited by: 297
References: 30
Citations by year: 2026: 26 · 2025: 31 · 2024: 35 · 2023: 59 · 2022: 54 · 2021: 40 · 2020: 23 · 2019: 18 · 2018: 11
FWCI: 6.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Biomedicine & Pharmacotherapy (publishedVersion)
PubMed (publishedVersion)
Funders: Jiangsu Province Qing Nian Ren Cai (QNRC2016432)
Huai’an Science Support Project (HASZ2013030)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: trimethylamine N-oxide, atherosclerosis, CD36, foam cell formation, macrophage recruitment, macrophage migration, oxidized LDL, inflammatory cytokines, ICAM-1, plaque progression, ApoE-deficient mice, high-fat diet, cardiovascular risk factors
MeSH terms: RAW 264.7 Cells, Animals, Apolipoproteins E, Disease Models, Animal, Foam Cells, Lipoproteins, LDL, Macrophages, Male, Methylamines, Mice, Inbred C57BL, Cytokines, Macrophages, Peritoneal, Mice, Knockout, Disease Progression, CD36 Antigens, MAP Kinase Signaling System, Atherosclerosis, Mice, Gene Knockdown Techniques, Plaque, Atherosclerotic

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Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway

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