Madecassoside prevents acute liver failure in LPS/D-GalN-induced mice by inhibiting p38/NF-κB and activating Nrf2/HO-1 signaling
Abstract
Madecassoside (MA), a triterpenoid saponin isolated from Centella asiatica, exerts various pharmacological activities including antioxidative and anti-inflammatory effects. The aim of this study was to explore the protective effect of MA in the treatment of lipopolysaccharide (LPS) and D-galactosamine (D-GalN)-induced acute liver failure(ALF) in mice. We hypothesized that MA administration may decrease the degree of liver injury caused by LPS/D-GalN. In this study, we investigated this hypothesis by treating a mouse model of LPS/D-GalN-induced liver injury with MA. Our study demonstrated that MA (20 mg/kg and 40 mg/kg) treatment for 10 days attenuated LPS/D-GalN-induced liver injury by protecting liver function, suppressing the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6, and recovering antioxidant enzyme activity. MA also significantly suppressed LPS-stimulated protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 by blocking the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and eukaryotic transcription factor nuclear factor-kappa B (NF-κB). In addition, MA treatment enhanced protein levels of heme oxygenase (HO)-1 and anti-oxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) through the upregulation of nuclear factor E2-related factor 2 (Nrf2) in LPS-stimulated liver injury. These results suggest that MA is a promising agent for the treatment o…
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Asiaticoside and madecassoside are promising hepatoprotective agents for acute liver injury or liver failure.
“Thus asiaticoside and madecassoside are promising hepatoprotective agents for acute liver injury or liver failure.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [106]
Madecassoside exhibits both antioxidative and anti-inflammatory effects in LPS/D-GalN-induced hepatic damage in mice.
“Madecassoside exhibited both antioxidative and anti‐inflammatory effects in LPS/D‐GalN‐induced hepatic damage in mice.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [106]
Madecassoside attenuates liver injury by protecting liver function, suppressing production of inflammatory cytokines (TNF-α, IL-1β and IL-6), restoring/enhancing antioxidant enzyme activity and suppressing LPS-stimulated proteins.
“Madecassoside attenuated liver injury by protecting liver function, suppressing the production of inflammatory cytokines (TNF‐α, IL‐1β and IL‐6), restoring/enhancing antioxidant enzyme activity and suppressing LPS‐stimulated proteins.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [106]
Asiaticoside and madecassoside show significant protection against LPS/D-GalN-induced acute liver injury.
“Asiaticoside and madecassoside have shown significant protection against lipopolysaccharide (LPS)/D‐galactosamine (D‐GaIN)‐induced acute liver injury in two separate studies.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [106]
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- Authors
- Wang, W., Wu, L., Li, Q., Zhang, Z., Xu, L., Lin, C., Gao, L., Zhao, K., Liang, F., Zhang, Q., Zhou, M., & Jiang, W.
- Affiliations
- Guangxi Medical University (CN)
- Corresponding author
- Jiang, Weizhe
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 103
- Pages
- 1137-1145
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W2800337036
- Cited by
- 51
- References
- 0
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 11 · 2020: 5 · 2019: 4 · 2018: 3
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81260511)
- Guangxi Key Research and Development Program (AB16380187)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal plant effects and applications
- Keywords
- madecassoside, Centella asiatica, acute liver failure, hepatoprotection, p38 MAPK, NF-κB, Nrf2/HO-1 pathway, inflammatory cytokines, inducible nitric oxide synthase, cyclooxygenase-2, antioxidant enzymes, triterpenoid saponins
- MeSH terms
- Animals, Antioxidants, Disease Models, Animal, Galactosamine, Lipopolysaccharides, Male, Membrane Proteins, Mice, Inbred Strains, Triterpenes, Signal Transduction, NF-kappa B, Centella, p38 Mitogen-Activated Protein Kinases, NF-E2-Related Factor 2, Heme Oxygenase-1, Chemical and Drug Induced Liver Injury
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