Actions and Therapeutic Potential of Madecassoside and Other Major Constituents of Centella asiatica: A Review

Idiopathic pulmonary fibrosis

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Pharmacological review on Centella asiatica: A potential herbal cure-all

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Chemical, pharmacological and clinical profile of the East Asian medical plant Centella aslatica

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In Vitro and in Vivo Wound Healing Activity of Asiaticoside Isolated from Centella Asiatica

Shukla, A., Rasik, A. M., Jain, G. K., Shankar, R., Kulshrestha, D. K., & Dhawan, B. N. (1999) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(98)00141-x · Cited by 428 · see citing works

Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-κB) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes

Liacini, A., Sylvester, J., Li, W., & Zafarullah, M. (2002) · Matrix Biology · doi:10.1016/s0945-053x(02)00007-0 · Cited by 403 · see citing works

Collagen-induced arthritis, an animal model of autoimmunity

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Asiaticoside-induced elevation of antioxidant levels in healing wounds

Shukla, A., Rasik, A. M., & Dhawan, B. N. (1999) · Phytotherapy Research · doi:10.1002/(sici)1099-1573(199902)13:1 · Cited by 266 · see citing works

Animal models of rheumatoid arthritis and their relevance to human disease

Kannan, K., Ortmann, R., & Kimpel, D. L. (2005) · Pathophysiology · doi:10.1016/j.pathophys.2005.07.011 · Cited by 238 · see citing works

Asiatic Acid, a Triterpene, Induces Apoptosis and Cell Cycle Arrest through Activation of Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways in Human Breast Cancer Cells

Hsu, Y.-L., Kuo, P.-L., Lin, L., & Lin, C. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.078808 · Cited by 228 · see citing works

Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise

Meeran, M. F. N., Goyal, S. N., Suchal, K., Sharma, C., Patil, C. R., & Ojha, S. K. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00892 · Cited by 199 · see citing works

A Tale of Two Joints: The Role of Matrix Metalloproteases in Cartilage Biology

Rose, B. J., & Kooyman, D. L. (2016) · Disease Markers · doi:10.1155/2016/4895050 · Cited by 184 · see citing works

Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells

Park, B. C., Bosire, K. O., Lee, E.-S., et al. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.06.039 · Cited by 180 · see citing works

Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica

Wattanathorn, J., Mator, L., Muchimapura, S., Tong-un, T., Pasurivong, O., Piyawatkul, N., Yimtae, K., Sripanidkulchai, B., & Singkhoraard, J. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.11.038 · Cited by 179 · see citing works

Asiatic acid attenuates methamphetamine-induced neuroinflammation and neurotoxicity through blocking of NF-kB/STAT3/ERK and mitochondria-mediated apoptosis pathway

Park, J.-H., Seo, Y. H., Jang, J.-H., Jeong, C.-H., Lee, S., & Park, B. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1009-0 · Cited by 175 · see citing works

Doxorubicin Inactivates Myocardial Cytochrome c Oxidase in Rats: Cardioprotection by Mito-Q

Chandran, K., Aggarwal, D., Migrino, R. Q., Joseph, J., McAllister, D. M., Konorev, E. A., Antholine, W. E., Zielonka, J., Srinivasan, S., Avadhani, N. G., et al. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.10.042 · Cited by 171 · see citing works

Evaluation of anxiolytic properties of Gotukola – (Centella asiatica) extracts and asiaticoside in rat behavioral models

Wijeweera, P., Arnason, J. T., Koszycki, D., & Merali, Z. (2006) · Phytomedicine · doi:10.1016/j.phymed.2006.01.011 · Cited by 171 · see citing works

Enrichment and purification of madecassoside and asiaticoside from Centella asiatica extracts with macroporous resins

Jia, G., & Lü, X. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.04.024 · Cited by 166 · see citing works

Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells

Xu, M.-F., Xiong, Y.-Y., Liu, J.-K., Qian, J.-J., Zhu, L., & Gao, J. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.3 · Cited by 156 · see citing works

Asiatic acid, a pentacyclic triterpene from <i>Centella asiatica</i>, is neuroprotective in a mouse model of focal cerebral ischemia

Krishnamurthy, R. G., Senut, M., Zemke, D., Min, J., Frenkel, M. B., Greenberg, E. J., Yu, S., Ahn, N., Goudreau, J., Kassab, M., et al. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22071 · Cited by 155 · see citing works

Involvement of tumor necrosis factor-α in development of hepatic injury in galactosamine-sensitized mice

Hishinuma, I., Nagakawa, J., Hirota, K., Miyamoto, K., Tsukidate, K., Yamanaka, T., Katayama, K., & Yamatsu, I. (1990) · Hepatology · doi:10.1002/hep.1840120518 · Cited by 154 · see citing works

Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts

Tang, B., Zhu, B., Liang, Y., Bi, L., Hu, Z., Chen, B., Zhang, K., & Zhu, J. (2011) · Archives of Dermatological Research · doi:10.1007/s00403-010-1114-8 · Cited by 151 · see citing works

Hepatocyte Growth Factor Attenuates Collagen Accumulation in a Murine Model of Pulmonary Fibrosis

Dohi, M., Hasegawa, T., Yamamoto, K., et al. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.6.9908097 · Cited by 151 · see citing works

Protecting the ischaemic and reperfused myocardium in acute myocardial infarction: distant dream or near reality?

Yellon, D. M., & Baxter, G. F. (2000) · Heart · doi:10.1136/heart.83.4.381 · Cited by 149 · see citing works

Madecassoside Isolated from<i>Centella asiatica</i>Herbs Facilitates Burn Wound Healing in Mice

Liu, M., Dai, Y., Li, Y., Luo, Y., Huang, F., Gong, Z., & Meng, Q. (2008) · Planta Medica · doi:10.1055/s-2008-1074533 · Cited by 142 · see citing works

Reperfusion injury revisited: is there a role for growth factor signaling in limiting lethal reperfusion injury?

Yellon, D., & Baxter, G. F. (1999) · Trends in cardiovascular medicine · doi:10.1016/s1050-1738(00)00029-3 · Cited by 141 · see citing works

Asiatic acid, a triterpene, induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cells

Lee, Y. S., Jin, D., Kwon, E. J., Park, S. H., Lee, E.-S., Jeong, T. C., Nam, D. H., Huh, K. Y., & Kim, J. (2002) · Cancer Letters · doi:10.1016/s0304-3835(02)00260-4 · Cited by 140 · see citing works

Gotu Kola (Centella asiatica)

Chandrika, U. G., & Kumara, P. A. A. S. P. (2015) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2015.08.001 · Cited by 137 · see citing works

Asiatic Acid Inhibits Liver Fibrosis by Blocking TGF-beta/Smad Signaling In Vivo and In Vitro

Tang, L., He, R.-H., Yang, G., Jia-ju, T., Zhou, L., Meng, X.-M., Huang, X. R., & Lan, H. Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031350 · Cited by 130 · see citing works

Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways

Ogunwobi, O. O., & Liu, C. (2011) · Clinical & Experimental Metastasis · doi:10.1007/s10585-011-9404-x · Cited by 129 · see citing works

Thymoquinone attenuates Doxorubicin-induced nephrotoxicity in rats: Role of Nrf2 and NOX4

Elsherbiny, N. M., & El‐Sherbiny, M. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.09.015 · Cited by 128 · see citing works

Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model

Lee, M. H., Kim, H.-L., Lee, M. H., You, K. E., Kwon, B., Seo, H. J., & Park, J. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.08.002 · Cited by 127 · see citing works

1990-2010 Global Cardiovascular Disease Atlas

Moran, A. E., Roth, G. A., Narula, J., & Mensah, G. A. (2014) · Global Heart · doi:10.1016/j.gheart.2014.03.1220 · Cited by 127 · see citing works

Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism

Kimura, Y., Sumiyoshi, M., Samukawa, K.-I., Satake, N., & Sakanaka, M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.036 · Cited by 126 · see citing works

Asiaticoside Induces Human Collagen I Synthesis through TGFβ Receptor I Kinase (TβRI Kinase)-Independent Smad Signaling

Lee, J., Jung, E., Kim, Y., Park, J., Park, J., Hong, S., Kim, J., Hyun, C., Kim, Y. S., & Park, D. (2006) · Planta Medica · doi:10.1055/s-2005-916227 · Cited by 123 · see citing works

An improved HPLC-UV method for the simultaneous quantification of triterpenic glycosides and aglycones in leaves of Centella asiatica (L.) Urb (APIACEAE)

Rafamantanana, M. H., Rozet, E., Raoelison, G. E., Cheuk, K., Ratsimamanga, S., Hubert, P., & Quetin‐Leclercq, J. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.03.018 · Cited by 119 · see citing works

Glucose uptake through translocation and activation of GLUT4 in PI3K/Akt signaling pathway by asiatic acid in diabetic rats

Vinayagam, R., & Saravanan, R. (2015) · Human & Experimental Toxicology · doi:10.1177/0960327114561663 · Cited by 115 · see citing works

Efficacy of asiatic acid, a pentacyclic triterpene on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-induced diabetic rats

Vinayagam, R., & Saravanan, R. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.09.023 · Cited by 113 · see citing works

A Double-Blind, Placebo-Controlled Study on the Effects of Gotu Kola (Centella asiatica) on Acoustic Startle Response in Healthy Subjects

Bradwejn, J., Zhou, Y., Koszycki, D., & Shlik, J. (2000) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200012000-00015 · Cited by 113 · see citing works

Comparative analysis of active constituents in Centella asiatica samples from Madagascar: Application for ex situ conservation and clonal propagation

Randriamampionona, D., Diallo, B., Rakotoniriana, E. F., Rabemanantsoa, C., Cheuk, K., Corbisier, A.-M., Mahillon, J., Ratsimamanga, S., & Jaziri, M. E. (2007) · Fitoterapia · doi:10.1016/j.fitote.2007.03.016 · Cited by 112 · see citing works

Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway

Xu, X., Wang, Y., Wei, Z., Wei, W.-H., Zhao, P., Tong, B., Xia, Y., & Dai, Y. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.150 · Cited by 111 · see citing works

Hepatotoxicity associated with the ingestion of Centella asiatica

Jorge, O., & Jorge, A. (2005) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082005000200006 · Cited by 110 · see citing works

Asiatic Acid Alleviates Hemodynamic and Metabolic Alterations via Restoring ENOS/INOS Expression, Oxidative Stress, and Inflammation in Diet-Induced Metabolic Syndrome Rats

Pakdeechote, P., Bunbupha, S., Kukongviriyapan, U., Prachaney, P., Khrisanapant, W., & Kukongviriyapan, V. (2014) · Nutrients · doi:10.3390/nu6010355 · Cited by 109 · see citing works

Asiatic Acid Induces Colon Cancer Cell Growth Inhibition and Apoptosis through Mitochondrial Death Cascade

Tang, X., Yang, X., Jung, H., et al. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.1399 · Cited by 108 · see citing works

Asiatic acid attenuates CCl 4 -induced liver fibrosis in rats by regulating the PI3K/AKT/mTOR and Bcl-2/Bax signaling pathways

Wei, L., Chen, Q., Guo, A., Fan, J., Wang, R., & Zhang, H. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.04.016 · Cited by 108 · see citing works

Identification of Major Active Ingredients Responsible for Burn Wound Healing of<i>Centella asiatica</i>Herbs

Wu, F., Bian, D., Xia, Y., Gong, Z., Tan, Q., Chen, J., & Dai, Y. (2012) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2012/848093 · Cited by 105 · see citing works

Treatment of renal fibrosis by rebalancing TGF-β/Smad signaling with the combination of asiatic acid and naringenin

Meng, X., Zhang, Y., Huang, X., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6100 · Cited by 100 · see citing works

Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis

Zhang, X., Wu, J., Dou, Y., Xia, B., Rong, W., Rimbach, G., & Lou, Y. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.01.006 · Cited by 99 · see citing works

Asiatic acid inhibits lung cancer cell growth in vitro and in vivo by destroying mitochondria

Wu, T., Geng, J., Guo, W., Gao, J., & Zhu, X. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.04.003 · Cited by 98 · see citing works

Production of asiaticoside and madecassoside in Centella asiatica in vitro and in vivo

Aziz, Z. A., Davey, M. R., Power, J. B., Anthony, P., Smith, R. M., & Lowe, K. C. (2007) · Biologia Plantarum · doi:10.1007/s10535-007-0008-x · Cited by 97 · see citing works

Asiaticoside attenuates memory impairment induced by transient cerebral ischemia–reperfusion in mice through anti-inflammatory mechanism

Chen, S., Yin, Z.-J., Jiang, C., Ma, Z., Fu, Q., Qu, R., & Ma, S. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.03.004 · Cited by 96 · see citing works

Clinical, biometric and structural evaluation of the long‐term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin

Haftek, M., Mac‐Mary, S., Bitoux, M. L., Creidi, P., Seité, S., Rougier, A., & Humbert, P. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00732.x · Cited by 95 · see citing works

Inhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytes

Lee, Y. S., Jin, D., Beak, S.-M., Lee, E.-S., & Kim, J. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)02177-0 · Cited by 92 · see citing works

Withanolide A and Asiatic Acid Modulate Multiple Targets Associated with Amyloid-β Precursor Protein Processing and Amyloid-β Protein Clearance

Patil, S. P., Maki, S., Khedkar, S. A., Rigby, A. C., & Chan, C. (2010) · Journal of Natural Products · doi:10.1021/np900633j · Cited by 91 · see citing works

Asiatic acid ameliorates pulmonary fibrosis induced by bleomycin (BLM) via suppressing pro-fibrotic and inflammatory signaling pathways

Dong, S.-H., Liu, Y., Wei, F., Tan, H., & Han, Z.-D. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.03.005 · Cited by 89 · see citing works

Untitled work

(2010) · PubMed · Cited by 87 · see citing works

Anti-Rheumatoid Arthritic Effect of Madecassoside on Type II Collagen-Induced Arthritis in Mice

Liu, M., Dai, Y., Yao, X., Li, Y., Luo, Y., Xia, Y., & Gong, Z. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.06.011 · Cited by 87 · see citing works

Madecassoside attenuates inflammatory response on collagen-induced arthritis in DBA/1 mice

Li, H., Gong, X., Zhang, L., Zhang, Z., Luo, F., Zhou, Q., Chen, J., & Wan, J. (2009) · Phytomedicine · doi:10.1016/j.phymed.2008.11.002 · Cited by 85 · see citing works

Protective Effects of Asiatic Acid on Rotenone- or H2O2-Induced Injury in SH-SY5Y Cells

Xiong, Y., Ding, H., Minfang, X., & Gao, J. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9844-0 · Cited by 85 · see citing works

Asiaticoside: Attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax

Xu, C.-L., Wang, Q.-Z., Sun, L.-M., Li, X.-M., Deng, J.-M., Li, L.-F., Zhang, J., Xu, R., & Ma, S.-P. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.09.014 · Cited by 85 · see citing works

Neuroprotective effects of madecassoside in early stage of Parkinson's disease induced by MPTP in rats

Xu, C.-L., Qu, R., Zhang, J., Li, L.-F., & Ma, S.-P. (2013) · Fitoterapia · doi:10.1016/j.fitote.2013.07.009 · Cited by 84 · see citing works

Antidiabetic and antihyperlipidemic activity of asiatic acid in diabetic rats, role of HMG CoA: In vivo and in silico approaches

Vinayagam, R., Saravanan, R., & Senthilraja, P. (2013) · Phytomedicine · doi:10.1016/j.phymed.2013.08.027 · Cited by 84 · see citing works

Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer rsquo s disease

Justin Thenmozhi, A. (2018) · Frontiers in Bioscience · doi:10.2741/s514 · Cited by 84 · see citing works

Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro

Su, Z., Ye, J., Qin, Z., & Ding, X. (2015) · Scientific Reports · doi:10.1038/srep18314 · Cited by 83 · see citing works

Neuroprotective effect of asiatic acid on rotenone-induced mitochondrial dysfunction and oxidative stress-mediated apoptosis in differentiated SH-SYS5Y cells

Nataraj, J., Manivasagam, T., Thenmozhi, A. J., & Essa, M. M. (2016) · Nutritional Neuroscience · doi:10.1080/1028415x.2015.1135559 · Cited by 81 · see citing works

Asiatic acid exerts anticancer potential in human ovarian cancer cells via suppression of PI3K/Akt/mTOR signalling

Ren, L., Cao, Q., Zhai, F.-R., Yang, S.-Q., & Zhang, H. (2016) · Pharmaceutical Biology · doi:10.3109/13880209.2016.1156709 · Cited by 81 · see citing works

Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/D-galactosamine in mice

Zhang, L., Li, H.-Z., Gong, X., Luo, F.-L., Wang, B., Hu, N., Wang, C.-D., Zhang, Z., & Wan, J.-Y. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.01.008 · Cited by 79 · see citing works

Biopharmaceutical and pharmacokinetic characterization of asiatic acid in Centella asiatica as determined by a sensitive and robust HPLC–MS method

Yuan, Y., Zhang, H., Feng-feng, S. U. N., Sun, S., Zhu, Z., & Chai, Y. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.01.006 · Cited by 79 · see citing works

Identification of triterpenoid compounds of Centella asiatica by thin‐layer chromatography and mass spectrometry

Bonfill, M., Mangas, S., Cusido, R. M., Osuna, L., Piñol, M. T., & Palazón, J. (2005) · Biomedical Chromatography · doi:10.1002/bmc.564 · Cited by 76 · see citing works

Asiatic Acid Isolated From Centella Asiatica Inhibits TGF-β1-induced Collagen Expression in Human Keloid Fibroblasts via PPAR-γ Activation

Bian, D., Zhang, J., Wu, X., Dou, Y., Yang, Y., Tan, Q., Xia, Y., Gong, Z., & Dai, Y. (2013) · International Journal of Biological Sciences · doi:10.7150/ijbs.7273 · Cited by 76 · see citing works

Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K/Akt/NF-κB pathway

Yin, Z., Yu, H., Chen, S., Ma, C., Ma, X., Xu, L., Ma, Z., Qu, R., & Ma, S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.06.024 · Cited by 75 · see citing works

Synthesis and biological evaluation of novel aniline-derived asiatic acid derivatives as potential anticancer agents

Li, J., Huang, R.-Z., Yao, G., et al. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.08.003 · Cited by 74 · see citing works

Asiatic acid protects against cisplatin-induced acute kidney injury via anti-apoptosis and anti-inflammation

Yang, C., Guo, Y., Huang, T.-S., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.126 · Cited by 74 · see citing works

Asiatic Acid Prevents the Deleterious Effects of Valproic Acid on Cognition and Hippocampal Cell Proliferation and Survival

Welbat, J. U., Sirichoat, A., Chaijaroonkhanarak, W., Prachaney, P., Pannangrong, W., Pakdeechote, P., Sripanidkulchai, B., & Wigmore, P. M. (2016) · Nutrients · doi:10.3390/nu8050303 · Cited by 73 · see citing works

Asiaticoside Attenuates Cell Growth Inhibition and Apoptosis Induced by Aβ1-42 via Inhibiting the TLR4/NF-κB Signaling Pathway in Human Brain Microvascular Endothelial Cells

Song, D., Jiang, X., Liu, Y., Sun, Y., Cao, S., & Zhang, Z. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00028 · Cited by 72 · see citing works

Pharmacokinetics of the total triterpenic fraction of Centella asiatica after single and multiple administrations to healthy volunteers. A new assay for asiatic acid

Grimaldi, R., Ponti, F. D., D'Angelo, L., et al. (1990) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(90)90033-p · Cited by 71 · see citing works

Glioblastoma cell death induced by asiatic acid

Cho, C., Choi, D. S., Cardone, M. H., et al. (2006) · Cell Biology and Toxicology · doi:10.1007/s10565-006-0104-2 · Cited by 71 · see citing works

Titrated Extract of Centella Asiatica (TECA) in the Treatment of Venous Insufficiency of the Lower Limbs

Pointel, J. P., Boccalon, H., Cloarec, M., Ledevehat, C., & Joubert, M. (1987) · Angiology · doi:10.1177/000331978703800106 · Cited by 71 · see citing works

Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer

Hausen, B. M. (1993) · Contact Dermatitis · doi:10.1111/j.1600-0536.1993.tb03532.x · Cited by 71 · see citing works

Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKα Signalling Pathway

Ma, Z., Dai, J., Wei, W., Zhang, W.-B., Xu, S., Liao, H.-H., Yang, Z., & Tang, Q. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.14213 · Cited by 71 · see citing works

Neuroprotective effects of madecassoside against focal cerebral ischemia reperfusion injury in rats

Luo, Y., Yang, Y., Liu, J., Li, W.-H., Yang, J., Sui, X. Y., Yuan, X., Nie, Z., Liu, Y., Chen, D., et al. (2014) · Brain Research · doi:10.1016/j.brainres.2014.04.008 · Cited by 70 · see citing works

Effects of Asiatic Acid on Spatial Working Memory and Cell Proliferation in the Adult Rat Hippocampus

Sirichoat, A., Chaijaroonkhanarak, W., Prachaney, P., Pannangrong, W., Leksomboon, R., Chaichun, A., Wigmore, P. M., & Welbat, J. U. (2015) · Nutrients · doi:10.3390/nu7105401 · Cited by 69 · see citing works

Burn wound healing properties of asiaticoside and madecassoside

Hou, Q., Li, M., Lu, Y., Liu, D., & Li, C.-C. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3459 · Cited by 69 · see citing works

Elite genotypes/chemotypes, with high contents of madecassoside and asiaticoside, from sixty accessions of Centella asiatica of south India and the Andaman Islands: For cultivation and utility in cosmetic and herbal drug applications

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Asiatic acid preserves beta cell mass and mitigates hyperglycemia in streptozocin‐induced diabetic rats

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Neurotrophic Effect of Asiatic acid, a Triterpene of Centella asiatica Against Chronic 1-Methyl 4-Phenyl 1, 2, 3, 6-Tetrahydropyridine Hydrochloride/Probenecid Mouse Model of Parkinson’s disease: The Role of MAPK, PI3K-Akt-GSK3β and mTOR Signalling Pathways

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Asiatic Acid Reduces Blood Pressure by Enhancing Nitric Oxide Bioavailability with Modulation of eNOS and p47phox Expression in l ‐NAME‐induced Hypertensive Rats

Bunbupha, S., Pakdeechote, P., Kukongviriyapan, U., Prachaney, P., & Kukongviriyapan, V. (2014) · Phytotherapy Research · doi:10.1002/ptr.5156 · Cited by 67 · see citing works

Asiatic Acid Attenuates Myocardial Ischemia/Reperfusion Injury via Akt/GSK-3β/HIF-1α Signaling in Rat H9c2 Cardiomyocytes

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Disruption of the endoplasmic reticulum and increases in cytoplasmic calcium are early events in cell death induced by the natural triterpenoid Asiatic acid

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Asiatic acid inhibits pulmonary inflammation induced by cigarette smoke

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Asiatic acid alleviates cardiovascular remodelling in rats with L‐ NAME ‐induced hypertension

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Asiatic Acid Inhibits Lipopolysaccharide-Induced Acute Lung Injury in Mice

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Anti-Diabetic Effects of Madecassic Acid and Rotundic Acid

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Asiatic acid and maslinic acid attenuated kainic acid-induced seizure through decreasing hippocampal inflammatory and oxidative stress

Wang, Z., Mong, M., Yang, Y., & Yin, M. (2017) · Epilepsy Research · doi:10.1016/j.eplepsyres.2017.11.003 · Cited by 60 · see citing works

Asiatic acid ameliorates CC l4-induced liver fibrosis in rats: involvement of Nrf2/ARE, NF-κB/IκBα, and JAK1/STAT3 signaling pathways

Fan, J., Chen, Q., Wei, L., Zhou, X., Wang, R., & Zhang, H. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s179876 · Cited by 60 · see citing works

Asiatic Acid Attenuates Infarct Volume, Mitochondrial Dysfunction, and Matrix Metalloproteinase-9 Induction After Focal Cerebral Ischemia

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Madecassoside, a triterpenoid saponin isolated from Centella asiatica herbs, protects endothelial cells against oxidative stress

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Asiatic Acid Ameliorates Doxorubicin-Induced Cardiac and Hepato-Renal Toxicities with Nrf2 Transcriptional Factor Activation in Rats

Kamble, S. M., & Patil, C. R. (2018) · Cardiovascular Toxicology · doi:10.1007/s12012-017-9424-0 · Cited by 59 · see citing works

In vivo studies on the protective effect of propolis on doxorubicin-induced toxicity in liver of male rats

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Asiatic acid protects against cognitive deficits and reductions in cell proliferation and survival in the rat hippocampus caused by 5-fluorouracil chemotherapy

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Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo

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Asiatic acid protects differentiated PC12 cells from Aβ25–35-induced apoptosis and tau hyperphosphorylation via regulating PI3K/Akt/GSK-3β signaling

Cheng, W., Chen, W., Wang, P., & Chu, J. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.07.016 · Cited by 57 · see citing works

Protective effect of madecassoside against cognitive impairment induced by d-galactose in mice

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Asiatic acid prevents the quinolinic acid-induced oxidative stress and cognitive impairment

Loganathan, C., & Palvannan, T. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0143-9 · Cited by 56 · see citing works

Asiaticoside attenuates lipopolysaccharide-induced acute lung injury via down-regulation of NF-κB signaling pathway

Qiu, J., Yu, L., Zhang, X., Wu, Q., Wang, D., Wang, X., Xia, C., & Feng, H. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.03.022 · Cited by 55 · see citing works

In vivo disposition and metabolism of madecassoside, a major bioactive constituent in Centella asiatica (L.) Urb.

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Antidepressant-like effect of asiaticoside in mice

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Madecassoside suppresses LPS-induced TNF-α production in cardiomyocytes through inhibition of ERK, p38, and NF-κB activity

Cao, W., Li, X., Zhang, X., Hou, Y., Zeng, A., Xie, Y., & Wang, S. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.03.015 · Cited by 53 · see citing works

Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway

Ma, K., Zhang, Y., Zhu, D., & Lou, Y. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.11.054 · Cited by 53 · see citing works

Madecassoside Inhibits Melanin Synthesis by Blocking Ultraviolet-Induced Inflammation

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Evaluation of Treatment of Diabetic Microangiopathy with Total Triterpenic Fraction of Centella asiatica: A Clinical Prospective Randomized Trial with a Microcirculatory Model

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Inhibitory Effects of Asiatic Acid on 7,12-Dimethylbenz[a]anthracene and 12-O-Tetradecanoylphorbol 13-Acetate-Induced Tumor Promotion in Mice

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In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica

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Asiatic acid inhibits proliferation, migration and induces apoptosis by regulating Pdcd4 via the PI3K/Akt/mTOR/p70S6K signaling pathway in human colon carcinoma cells

Hao, Y., Huang, J., Ma, Y., Chen, W., Fan, Q., Sun, X., Shao, M., & Cai, H. (2018) · Oncology Letters · doi:10.3892/ol.2018.8417 · Cited by 51 · see citing works

Madecassoside prevents acute liver failure in LPS/D-GalN-induced mice by inhibiting p38/NF-κB and activating Nrf2/HO-1 signaling

Wang, W., Wu, L., Li, Q., Zhang, Z., Xu, L., Lin, C., Gao, L., Zhao, K., Liang, F., Zhang, Q., et al. (2018) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2018.04.162 · Cited by 51 · see citing works

Madecassoside suppresses migration of fibroblasts from keloids: involvement of p38 kinase and PI3K signaling pathways

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Madecassoside Reduces Ischemia-Reperfusion Injury on Regional Ischemia Induced Heart Infarction in Rat

Bian, G.-X., Li, G.-G., Yang, Y., Liu, R.-T., Ren, J.-P., Wen, L.-Q., Guo, S.-M., & Lu, Q.-J. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.458 · Cited by 50 · see citing works

Asiatic acid attenuated apoptotic and inflammatory stress in the striatum of MPTP-treated mice

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Relative importance of intracellular glutathione peroxidase and catalase in vivo for prevention of peroxidation to the heart

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Anxiolytic-like effect of asiaticoside in mice

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EFFECT OF CENTELLA ASIATICA ON MILD COGNITIVE IMPAIRMENT (MCI) AND OTHER COMMON AGE-RELATED CLINICAL PROBLEMS

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Effects of asiatic acid on passive and active avoidance task in male Spraque–Dawley rats

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Asiatic acid prevents lipid peroxidation and improves antioxidant status in rats with streptozotocin-induced diabetes

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Asiatic Acid Ameliorates Hepatic Lipid Accumulation and Insulin Resistance in Mice Consuming a High-Fat Diet

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Asiatic acid attenuates renin-angiotensin system activation and improves vascular function in high-carbohydrate, high-fat diet fed rats

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Acute and sub-chronic toxicity studies of a standardized extract of Centella asiatica ECa 233

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Comparative pharmacokinetics between madecassoside and asiaticoside presented in a standardised extract ofCentella asiatica, ECa 233 and their respective pure compound given separately in rats

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The comparative steady-state bioavailability of the active ingredients of madecassol

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Anti-glycative effects of asiatic acid in human keratinocyte cells

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Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma

Kwon, K. J., Bae, S., Kim, K., An, I. S., Ahn, K. J., An, S., & Cha, H. J. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2159 · Cited by 43 · see citing works

Improvement of Capillary Permeability in Patients with Venous Hypertension After Treatment with TTFCA

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Effect of asiaticoside on hypertrophic scar in the rabbit ear model

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Asiatic acid ameliorates hepatic ischemia/reperfusion injury in rats via mitochondria-targeted protective mechanism

Lu, Y., Kan, H., Wang, Y., Wang, D., Wang, X., Gao, J., & Zhu, L. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.11.023 · Cited by 43 · see citing works

Optimization of madecassoside liposomes using response surface methodology and evaluation of its stability

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Nerve Protective Effect of Asiaticoside against Ischemia-Hypoxia in Cultured Rat Cortex Neurons

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Asiatic acid protects against hepatic ischemia/reperfusion injury by inactivation of Kupffer cells via PPARγ/NLRP3 inflammasome signaling pathway

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Hippocampal BDNF signaling restored with chronic asiaticoside treatment in depression-like mice

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Protective effects of asiaticoside on septic lung injury in mice

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Preparation of Ursane Triterpenoids from Centella asiatica Using High Speed Countercurrent Chromatography with Step‐Gradient Elution

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What is the patient experience in advanced liver disease? A scoping review of the literature

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Asiaticoside protects cochlear hair cells from high glucose-induced oxidative stress via suppressing AGEs/RAGE/NF-κB pathway

Xing, Y., Ji, Q., Li, X., Ming, J., Zhang, N., Zha, D., & Lin, Y. L. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.12.025 · Cited by 41 · see citing works

Madecassoside activates anti‑neuroinflammatory mechanisms by inhibiting lipopolysaccharide‑induced microglial inflammation

Sasmita, A. O., Ling, A. P. K., Voon, K., Koh, R. Y., & Wong, Y. P. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3479 · Cited by 41 · see citing works

Asiatic Acid Prevents Oxidative Stress and Apoptosis by Inhibiting the Translocation of α-Synuclein Into Mitochondria

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Effects of the Total Triterpenic Fraction of Centella Asiatica in Venous Hypertensive Microangiopathy: A Prospective, Placebo-Controlled, Randomized Trial

Cesarone, M. R., Belcaro, G., De Sanctis, M. T., Incandela, L., Cacchio, M., Bavera, P., Ippolito, E., Bucci, M., Griffin, M., Geroulakos, G., et al. (2001) · Angiology · doi:10.1177/000331970105202s04 · Cited by 41 · see citing works

Study of the cytotoxicity of asiaticoside on rats and tumour cells

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MicroRNA-1290 promotes asiatic acid-induced apoptosis by decreasing BCL2 protein level in A549 non-small cell lung carcinoma cells

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Evaluation of the anxiolytic and antidepressant effects of asiatic acid, a compound from Gotu kola or Centella asiatica, in the male Sprague Dawley rat.

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Inhibitory effects of asiatic acid and CPT-11 on growth of HT-29 cells

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Medicinal value of asiaticoside for Alzheimer’s disease as assessed using single-molecule-detection fluorescence correlation spectroscopy, laser-scanning microscopy, transmission electron microscopy, and in silico docking

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Low temperature and water dehydration increase the levels of asiaticoside and madecassoside in Centella asiatica (L.) Urban

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Neuroprotective effects of Asiaticoside

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Antitumor Activity of Asiaticoside Against Multiple Myeloma Drug-Resistant Cancer Cells Is Mediated by Autophagy Induction, Activation of Effector Caspases, and Inhibition of Cell Migration, Invasion, and STAT-3 Signaling Pathway

Li, Y., Huihan, W., Zhang, R., Guojun, Z., Ying, Y., & Zhuogang, L. (2019) · Medical Science Monitor · doi:10.12659/msm.913397 · Cited by 37 · see citing works

Asiatic acid and maslinic acid protected heart via anti-glycative and anti-coagulatory activities in diabetic mice

Hung, Y.-C., Yang, H.-T., & Yin, M.-C. (2015) · Food & Function · doi:10.1039/c5fo00549c · Cited by 36 · see citing works

Asiatic acid uncouples respiration in isolated mouse liver mitochondria and induces HepG2 cells death

Lu, Y., Liu, S., Wang, Y., Wang, D., Gao, J., & Zhu, L. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.06.010 · Cited by 36 · see citing works

Presence of autocrine hepatocyte growth factor-Met signaling and its role in proliferation and migration of SNU-484 gastric cancer cell line

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Protective Effects of Asiatic Acid Against Spinal Cord Injury-Induced Acute Lung Injury in Rats

Jiang, W., Li, M.-Q., He, F., Yao, W., Bian, Z., Wang, X.-P., & Zhu, L.-L. (2016) · Inflammation · doi:10.1007/s10753-016-0414-3 · Cited by 35 · see citing works

Asiaticoside ameliorates β-amyloid-induced learning and memory deficits in rats by inhibiting mitochondrial apoptosis and reducing inflammatory factors

Zhang, Z., Li, X., Li, D., Luo, M., Li, Y., Li, S., & Jiang, X. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.4004 · Cited by 35 · see citing works

Madecassoside Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice by Downregulating Collagen Deposition

Lu, G.-X., Bian, D., Ji, Y., Guo, J., Wei, Z., Jiang, S., Xia, Y., & Dai, Y. (2014) · Phytotherapy Research · doi:10.1002/ptr.5120 · Cited by 34 · see citing works

Determination of asiatic acid in beagle dog plasma after oral administration of Centella asiatica extract by precolumn derivatization RP-HPLC

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Effects of asiaticoside on the expression of Smad protein by normal skin fibroblasts and hypertrophic scar fibroblasts

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Asiatic acid enhances survival of human AC16 cardiomyocytes under hypoxia by upregulating miR‐1290

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Treatment of Diabetic Microangiopathy and Edema with Total Triterpenic Fraction of Centella asiatica: A Prospective, Placebo-Controlled Randomized Study

INCANDELA, L., Belcaro, G., Cesarone, M. R., Sanctis, M. T. D., Nargi, E., Patricelli, P., & Bucci, M. (2001) · Angiology · doi:10.1177/000331970105202s06 · Cited by 33 · see citing works

Asiaticoside Inhibits TNF-α-Induced Endothelial Hyperpermeability of Human Aortic Endothelial Cells: Asiaticoside Suppresses TNF-α-Induced Increased Permeability

Fong, L. Y., Ng, C. T., Zakaria, Z. A., Baharuldin, M. T. H., Arifah, A. K., Hakim, M. N., & Zuraini, A. (2015) · Phytotherapy Research · doi:10.1002/ptr.5404 · Cited by 33 · see citing works

Prophylactic effects of asiaticoside-based standardized extract of Centella asiatica (L.) Urban leaves on experimental migraine: Involvement of 5HT1A/1B receptors

Bobade, V., Bodhankar, S. L., Aswar, U. M., Vishwaraman, M., & Thakurdesai, P. A. (2015) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(15)30014-5 · Cited by 33 · see citing works

Three pentacyclic triterpenes protect H9c2 cardiomyoblast cells against high-glucose-induced injury

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Asiatic acid, a triterpene, inhibits cell proliferation through regulating the expression of focal adhesion kinase in multiple myeloma cells

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Madecassoside protects BV2 microglial cells from oxygen-glucose deprivation/reperfusion-induced injury via inhibition of the toll-like receptor 4 signaling pathway

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Asiatic acid attenuates cardiac hypertrophy by blocking transforming growth factor-β1-mediated hypertrophic signaling in vitro and in vivo

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Neuroprotective effect of asiatic acid in rat model of focal embolic stroke

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Asiaticoside hinders the invasive growth of keloid fibroblasts through inhibition of the GDF‐9/MAPK/Smad pathway

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A liquid chromatography/electrospray ionization tandem mass spectrometric method for quantification of asiatic acid from plasma: application to pharmacokinetic study in rats

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Intestinal interleukin-10 mobilization as a contributor to the anti-arthritis effect of orally administered madecassoside: A unique action mode of saponin compounds with poor bioavailability

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Madecassoside ameliorates bleomycin‐induced pulmonary fibrosis in mice through promoting the generation of hepatocyte growth factor via PPAR‐γ in colon

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Protective effect of madecassoside on H2O2-induced oxidative stress and autophagy activation in human melanocytes

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Microcirculatory Effects of Total Triterpenic Fraction of Centella asiatica in Chronic Venous Hypertension: Measurement by Laser Doppler, TcPo 2 -co 2 , and Leg Volumetry

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Asiatic acid mitigates hyperglycemia and reduces islet fibrosis in Goto-Kakizaki rat, a spontaneous type 2 diabetic animal model

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Direct coupling of high-speed counter-current chromatography to thin-layer chromatography

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Asiatic acid inhibits left ventricular remodeling and improves cardiac function in a rat model of myocardial infarction

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Phytochemical screening, Antioxidant, Anti-Alzheimer and Anti-diabeticactivities of Centella asiatica

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Comparative antioxidant and anti-inflammatory activity of different extracts of centella asiatica (L.) urban and its active compounds, asiaticoside and madecassoside

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Apoptosis of HL-60 human leukemia cells induced by Asiatic acid through modulation of B-cell lymphoma 2 family proteins and the mitogen-activated protein kinase signaling pathway

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The metabolism of asiatic acid,-madecassic acid and asiaticoside in the rat.

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Pharmacological effects of asiatic acid in glioblastoma cells under hypoxia

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Asiaticoside: Attenuation of rotenone induced oxidative burden in a rat model of hemiparkinsonism by maintaining the phosphoinositide-mediated synaptic integrity

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High performance thin layer chromatography of asiaticoside in Centella asiatica

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Reticuloses and epidermal tumors in hairless mice after topical skin applications of cantharidin and asiaticoside.

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Allergic contact dermatitis from a cream containing Centella asiatica extract

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Barrier protective effect of asiatic acid in TNF-α-induced activation of human aortic endothelial cells

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Anti inflammatory effect of asiaticoside on human umbilical vein endothelial cells induced by ox-LDL

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Madecassoside suppresses proliferation and invasiveness of HGF-induced human hepatocellular carcinoma cells via PKC-cMET-ERK1/2-COX-2-PGE 2 pathway

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Effect of asiaticoside on the healing of skin wounds in the carp Cirrhinus mrigala: An immunohistochemical investigation

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Asiatic acid abridges pre-neoplastic lesions, inflammation, cell proliferation and induces apoptosis in a rat model of colon carcinogenesis

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A systematic review of the effect of Centella asiatica on wound healing

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A review of pharmacokinetic and pharmacological properties of asiaticoside, a major active constituent of Centella asiatica (L.) Urb.

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Towards a predicted anti-aging molecular targets of asiaticoside based on bioinformatics analysis

Ayu Kencana, M. V. S. (2025) · International Journal of Medical Biochemistry · doi:10.14744/ijmb.2024.26122 · Cited by 2 · see citing works

A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women.

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Pegaga (Centella asiatica)

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Determination of growth and distribution of Centella asiatica in the Anzali lagoon

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In vitro experiments with Centella asiatica: investigation to elucidate the effect of an indigenously prepared powder of this plant on the acid-fastness and viability of M. tuberculosis.

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Studies on the biological properties of extracts from Centella asiatica [L.] Urban herb

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