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Effect of different types of macrophages on hepatic fibrosis in Echinococcus Granulosus mice
Open accessAbstract
OBJECTIVE: The purpose of this study is to illustrate the therapeutic effect of which kind of polarized macrophages-based cell therapy in hepatic fibrosis caused by cystic echinococcosis. METHODS: The isolation culture and polarization induction of mouse bone marrow-derived macrophages (BMDM) are established in an in vitro environment. A model of Echinococcus granulosus infection is established by direct injection of the Echinococcus granulosus suspension into the left hepatic lobe. The macrophages are labeled in vitro and the localization of the returned macrophages in the liver of the mice is determined by in vivo tracing. Macrophages of different polarization types are injected into the successfully modeled mice through the tail vein, and the results of HE, Masson, Sirius Red, Desmin immunohistochemistry and Hyp content are inspected to evaluate by liver tissue. Liver pathology and changes in the degree of fibrosis. RESULTS: Bone marrow-derived macrophages have been successfully obtained and induced into M1 and M2 macrophages by different conditions; a model of Echinococcus granulosus infection was successfully established. Macrophages labeled in vitro were returned to the model through the tail vein and they can be located in the liver; a variety of experimental results show that compared with the PBS group, the degree of fibrosis in the M0 group and the M1 group have been reduced, with statistical difference, and the M1 is better than M0 in terms of the therapeutic effect. There is no significant change in the degree of fibrosis in the M2 group. CONCLUSION: Both M1 and M0 macrophages can alleviate liver fibrosis caused by persistent infection of Echinococcus granulosus, but the treatment effect of M1 macrophages is more significant. Cell therapy based on M1 macrophages may be a new idea for treating liver fibrosis caused by persistent infection of Echinococcus granulosus.
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Pro-fibrotic BMDM infusion is associated with a phenotypic shift of endogenous infiltrating monocytes toward a pro-resolutive macrophage phenotype.
“Pro-fibrotic BMDM infusion was associated with a phenotypic shift of endogenous infiltrating monocytes toward pro-resolutive macrophage phenotype, which mediate antifibrotic effects (1), although the underlying mechanisms in parasitic fibrosis remain incompletely understood.”
From Strategies to promote liver fibrosis amelioration with involvement of restorative macrophages (2026) · cites this paper as [168]
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Metadata
- Authors
- Li, B., Liu, Y.-M., Yan, Y., Yang, N., Gao, J., Jiang, T., Shang, X.-Q., Tian, F.-M., Ding, J.-B., & Ma, X.-M.
- Affiliations
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 117
- Pages
- 109178
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W2954657183
- Cited by
- 11
- References
- 17
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 1
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- State Key Laboratory of Pathogenesis, Prevention of Treatment of High Incidence Diseases in Central Asia Fund (SKL-HIDCA-2018-27)
- National Natural Science Foundation (81760372, 81260253, 31160194)
- Scientific Research Project of Science Department of Xinjiang Autonomous Region (2016D01C186)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Immunology and Microbiology › Parasitology › Parasitic infections in humans and animals
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Keywords
- liver fibrosis, Echinococcus granulosus, echinococcosis, macrophage polarization, M1 macrophages, M2 macrophages, M0 macrophages, bone marrow-derived macrophages, cell therapy, macrophage transplantation
- MeSH terms
- Animals, Disease Models, Animal, Echinococcosis, Female, Liver, Liver Cirrhosis, Macrophages, Mice, Inbred BALB C, Cell Polarity, Echinococcus granulosus, Mice, Cell- and Tissue-Based Therapy
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