The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols
Open accessAbstract
Osteoarthritis (OA) is the most prevalent joint degenerative disease leading to irreversible structural and functional changes in the joint and is a major cause of disability and reduced life expectancy in ageing population. Despite the high prevalence of OA, there is no disease modifying drug available for the management of OA. Oxidative stress, a result of an imbalance between the production of reactive oxygen species (ROS) and their clearance by antioxidant defense system, is high in OA cartilage and is a major cause of chronic inflammation. Inflammatory mediators, such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are highly upregulated in OA joints and induce ROS production and expression of matrix degrading proteases leading to cartilage extracellular matrix degradation and joint dysfunction. ROS and inflammation are interdependent, each being the target of other and represent ideal target/s for the treatment of OA. Plant polyphenols possess potent antioxidant and anti-inflammatory properties and can inhibit ROS production and inflammation in chondrocytes, cartilage explants and in animal models of OA. The aim of this review is to discuss the chondroprotective effects of polyphenols and modulation of different molecular pathways associated with OA pathogenesis and limitations and future prospects of polyphenols in OA treatment.
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Cited by
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Liu, S., Liu, J., Wang, Y., Deng, F., & Deng, Z. (2025) · MedComm · doi:10.1002/mco2.70268 · Cited by 359
Hu, D., Li, Y., Li, R., Wang, M., Zhou, K., He, C., Wei, Q., & Qian, Z. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.10.015 · Cited by 153
Valorization of Food Processing Waste to Produce Valuable Polyphenolics
Chang, Y., Shi, X., He, F., Wu, T., Jiang, L., Normakhamatov, N., Sharipov, A., Wang, T., Wen, M., & Aisa, H. A. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c02655 · Cited by 47
Sauty, S. M., Shine, J., Bostan, H., Li, J.-L., Mieczkowski, P. A., Loeser, R. F., Diekman, B. O., & Gordenin, D. A. (2026) · PLOS Genetics · doi:10.1371/journal.pgen.1012156
Metadata
- Authors
- Ansari, M. Y., Ahmad, N., & Haqqi, T. M.
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 129
- Pages
- 110452
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W3039656228
- Cited by
- 709
- References
- 127
- FWCI
- 41.00
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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