Cited by 70Mesenchymal stem cell researchPluripotent Stem Cells ResearchTissue Engineering and Regenerative Medicine

Translational insights into stem cell preconditioning: From molecular mechanisms to preclinical applications

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Moeinabadi-Bidgoli, Kasra, Babajani, Amirhesam, Yazdanpanah, Ghasem, Farhadihosseinabadi, Behrouz, Jamshidi, Elham, Bahrami, Soheyl, Niknejad, Hassan·2021·Biomedicine & Pharmacotherapy

Abstract

Cell-based therapy (CBT) is a revolutionary approach for curing a variety of degenerative diseases. Stem cell-based regenerative medicine is a novel strategy for treating tissue damages regarding stem cells unique properties such as differentiation potential, paracrine impacts, and self-renewal ability. However, the current cell-based treatments encounter considerable challenges to be translated into clinical practice, including low cell survival, migration, and differentiation rate of transplanted stem cells. The poor stem cell therapy outcomes mainly originate from the unfavorable condition of damaged tissues for transplanted stem cells. The promising method of preconditioning improves cell resistance against the host environment's stress by imposing certain conditions similar to the harsh microenvironment of the damaged tissues on the transplanted stem cells. Various pharmacological, biological, and physical inducers are able to establish preconditioning. In addition to their known pharmacological effects on tissues and cells, these preconditioning agents improve cell biological aspects such as cell survival, proliferation, differentiation, migration, immunomodulation, paracrine impacts, and angiogenesis. This review focuses on different protocols and inducers of preconditioning along with underlying molecular mechanisms of their effects on stem cell behavior. Moreover, preclinical applications of preconditioned stem cells in various damaged organs such as heart, lung, brain, bone, cartilage, liver, and kidney are discussed with prospects of their translation into the clinic.

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Crossref · 10.1016/j.biopha.2021.112026

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Authors
Moeinabadi-Bidgoli, K., Babajani, A., Yazdanpanah, G., Farhadihosseinabadi, B., Jamshidi, E., Bahrami, S., & Niknejad, H.
Affiliations
  • Shahid Beheshti University (IR)
  • University of Illinois Chicago (US)
  • Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA (AT)
Corresponding author
Niknejad, Hassan
Venue
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Published
2021-10
Volume
142
Pages
112026
ISSN
0753-3322 (ISSN-L)
OpenAlex
W3195914556
Cited by
70
References
191
Citations by year
2026: 8 · 2025: 14 · 2024: 16 · 2023: 20 · 2022: 11
FWCI
1.67
Type
journal article
Language
en
Open access
Locations
  • Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Shahid Beheshti University of Medical Sciences
  • National Institute for Medical Research Development (963951)
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
stem cell preconditioning, cell therapy, regenerative medicine, stem cell survival, stem cell migration, immunomodulation, paracrine effects, angiogenesis, tissue regeneration, preclinical applications, clinical translation
MeSH terms
Animals, Cell Differentiation, Cell Movement, Cell Survival, Humans, Stem Cells, Stem Cell Transplantation, Regenerative Medicine, Translational Research, Biomedical

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