Albendazole ameliorates inflammatory response in a rat model of acute mesenteric ischemia reperfusion injury
Open accessAbstract
BACKGROUND: Acute mesenteric ischemia is known as a life threatening condition. Re-establishment of blood flow in this condition can lead to mesenteric ischemia reperfusion (MIR) injury which is accompanied by inflammatory response. Still, clear blueprint of inflammatory mechanism underlying MIR injury has not been provided. Interestingly, Albendazole has exhibited notable effects on inflammation and cytokine production. In this study, we aimed to evaluate outcomes of MIR injury following pretreatment with Albendazole with respect to assessment of mesenteric inflammation and ischemia threshold. METHODS: Male rats were randomly divided into sham operated, vehicle treated, Albendazole 100 mg/kg and Albendazole 200 mg/kg groups. MIR injury was induced by occlusion of superior mesenteric artery for 30 min followed by 120 min of reperfusion. Samples were utilized for assessment of epithelial survival and villous height. Immunohistochemistry study revealed intestinal expression of TNF-α and HIF-1-α. Gene expression of NF-κB/TLR4/TNF-α/IL-6 was measured using RTPCR. Also protein levels of inflammatory cytokines in serum and intestine were assessed by ELISA method. RESULTS: Histopathological study demonstrated that pretreatment with Albendazole could ameliorate decline in villous height and epithelial survival following MIR injury. Also, systemic inflammation was suppressed after administration of Albendazole. Analysis of possible participating inflammatory pathway could demonstrate that intestinal expression of NF-κB/TLR4/TNF-α/IL-6 is significantly attenuated in treated groups. Eventually, IHC study illustrated concordant decline in mesenteric expression of HIF-1-α/TNF-α. CONCLUSION: Single dose pretreatment with Albendazole could ameliorate inflammatory response and enhance ischemia threshold following induction of MIR injury. More studies would clarify existing causality in this phenomenon.
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In animal models, single-dose pretreatment with albendazole might ameliorate the inflammatory response and increase the ischemia threshold after induction of mesenteric reperfusion injury.
“A study involving animal models suggested that single-dose pretreatment with albendazole might ameliorate the inflammatory response and increase the ischemia threshold after the induction of a mesenteric reperfusion injury [37].”
From Revascularization Strategies for Acute and Chronic Mesenteric Ischemia: A Narrative Review (2024) · cites this paper as [37]
In the animal study, treated groups had a reduction in proinflammatory cytokines.
“The study reported a reduction in proinflammatory cytokines in treated groups [37].”
From Revascularization Strategies for Acute and Chronic Mesenteric Ischemia: A Narrative Review (2024) · cites this paper as [37]
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- J. eZheng, P. Chen, J. Zhong, Y. Cheng, H. Chen, Y. He, et al., HIF-1α in myocardial ischemia-reperfusion injury (Review), Mol. Med. Rep. 23 (2021) 5.
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Revascularization Strategies for Acute and Chronic Mesenteric Ischemia: A Narrative Review
Gries, J. J., Sakamoto, T., Chen, B., Virk, H. U. H., Alam, M., & Krittanawong, C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13051217 · Cited by 19 · see citing works
“If endovascular revascularization approaches are undertaken, then combination therapies, such as stent thrombectomy plus aspiration, should be performed due to higher clearance rates, reduced adjunctive thrombolysis, and shorter hospitalization.”
Method
- Authors
- Badripour, A., Behzadi, M., Hassanipour, A., Azar, P. R. S., Rahbar, A., Abbaslou, Z., Ehghaghi, E., Piranviseh, A., Khavandi, M. M., Ahmadi-Tafti, S. M., Ashouri, M., Soltani, Z. E., & Dehpour, A.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Sina Hospital (IR)
- Eastern Mediterranean University (CY)
- Imam Khomeini Hospital (IR)
- Corresponding author
- Ashouri, Mohammad
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 153
- Pages
- 113320
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W4283273073
- Cited by
- 7
- References
- 58
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 1
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Eastern Mediterranean University Institutional Repository (Eastern Mediterranean University) (submittedVersion, cc-by-nc-nd)
- Funders
- Iran National Science Foundation (96002757)
- Tehran University of Medical Sciences (97-01-30-36808)
- Topics
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- albendazole, intestinal ischemia-reperfusion injury, intestinal inflammation, TNF-α, HIF-1α, interleukin-6, villous atrophy, superior mesenteric artery occlusion, anti-inflammatory agents
- MeSH terms
- Animals, Inflammation, Male, Tumor Necrosis Factor-alpha, Reperfusion Injury, Albendazole, Interleukin-6, NF-kappa B, Toll-Like Receptor 4, Rats, Mesenteric Ischemia
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