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Cited by 622

The DOI matches its Crossref record; 178 of the 178 references it cites were found in a registry or an index.

Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments

Open access
Antar, Samar A., Ashour, Nada A., Sharaky, Marwa, Khattab, Muhammad, Ashour, Naira A., Zaid, Roaa T., Roh, Eun Joo, Elkamhawy, Ahmed, Al-Karmalawy, Ahmed A.·2023·Biomedicine & Pharmacotherapy
DOI 10.1016/j.biopha.2023.115734
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Abstract

Nowadays, diabetes mellitus has emerged as a significant global public health concern with a remarkable increase in its prevalence. This review article focuses on the definition of diabetes mellitus and its classification into different types, including type 1 diabetes (idiopathic and fulminant), type 2 diabetes, gestational diabetes, hybrid forms, slowly evolving immune-mediated diabetes, ketosis-prone type 2 diabetes, and other special types. Diagnostic criteria for diabetes mellitus are also discussed. The role of inflammation in both type 1 and type 2 diabetes is explored, along with the mediators and potential anti-inflammatory treatments. Furthermore, the involvement of various organs in diabetes mellitus is highlighted, such as the role of adipose tissue and obesity, gut microbiota, and pancreatic β-cells. The manifestation of pancreatic Langerhans β-cell islet inflammation, oxidative stress, and impaired insulin production and secretion are addressed. Additionally, the impact of diabetes mellitus on liver cirrhosis, acute kidney injury, immune system complications, and other diabetic complications like retinopathy and neuropathy is examined. Therefore, further research is required to enhance diagnosis, prevent chronic complications, and identify potential therapeutic targets for the management of diabetes mellitus and its associated dysfunctions.

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Crossref · 10.1016/j.biopha.2023.115734

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Metadata

Authors
Antar, S. A., Ashour, N. A., Sharaky, M., Khattab, M., Ashour, N. A., Zaid, R. T., Roh, E. J., Elkamhawy, A., & Al-Karmalawy, A. A.
Venue
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Published
2023-12
Volume
168
Pages
115734
ISSN
0753-3322 (ISSN-L)
DOI
10.1016/j.biopha.2023.115734
OpenAlex
W4387720525
Cited by
622
References
178
FWCI
90.83
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments. https://app.cochat.ai/papers/10.1016/j.biopha.2023.115734
The paper
Antar, S. A., Ashour, N. A., Sharaky, M., Khattab, M., Ashour, N. A., Zaid, R. T., Roh, E. J., Elkamhawy, A., & Al-Karmalawy, A. A. (2023). Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments. Biomedicine & Pharmacotherapy. https://doi.org/10.1016/j.biopha.2023.115734

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.