CD19 CAR-expressing iPSC-derived NK cells effectively enhance migration and cytotoxicity into glioblastoma by targeting to the pericytes in tumor microenvironment

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

Neelapu, S. S., Locke, F. L., Bartlett, N. L., Lekakis, L. J., Miklos, D. B., Jacobson, C. A., Braunschweig, I., Oluwole, O. O., Siddiqi, T., Lin, Y., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707447 · Cited by 6,030 · see citing works

Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia

Maude, S. L., Laetsch, T. W., Buechner, J., Rives, S., Boyer, M., Bittencourt, H., Bader, P., Verneris, M. R., Stefanski, H. E., Myers, G. D., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1709866 · Cited by 5,735 · see citing works

Functions of natural killer cells

Vivier, E., Tomasello, E., Baratin, M., Walzer, T., & Ugolini, S. (2008) · Nature Immunology · doi:10.1038/ni1582 · Cited by 3,943 · see citing works

CAR-T cell therapy: current limitations and potential strategies

Sterner, R. C., & Sterner, R. M. (2021) · Blood Cancer Journal · doi:10.1038/s41408-021-00459-7 · Cited by 2,926 · see citing works

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

Morgan, R. A., Yang, J. C.-H., Kitano, M., Dudley, M. E., Laurençot, C. M., & Rosenberg, S. A. (2010) · Molecular Therapy · doi:10.1038/mt.2010.24 · Cited by 2,542 · see citing works

A Perivascular Niche for Brain Tumor Stem Cells

Calabrese, C. R., Poppleton, H., Koçak, M., Hogg, T. L., Fuller, C. E., Hamner, J. B., Oh, E. Y., Gaber, M. W., Finklestein, D., Allen, M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.11.020 · Cited by 2,203 · see citing works

Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer

Miller, J. S., Soignier, Y., Panoskaltsis‐Mortari, A., McNearney, S. A., Yun, G. H., Fautsch, S. K., McKenna, D. H., Le, C. T., DeFor, T. E., Burns, L. J., et al. (2005) · Blood · doi:10.1182/blood-2004-07-2974 · Cited by 1,894 · see citing works

Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy

Brown, C. E., Alizadeh, D., Starr, R., Weng, L., Wagner, J. R., Naranjo, A., Ostberg, J. R., Blanchard, M. S., Kilpatrick, J., Simpson, J., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1610497 · Cited by 1,842 · see citing works

The blood–brain barrier and blood–tumour barrier in brain tumours and metastases

Arvanitis, C., Ferraro, G. B., & Jain, R. K. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0205-x · Cited by 1,841 · see citing works

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

Goel, S., Duda, D. G., Xu, L., Munn, L. L., Boucher, Y., Fukumura, D., & Jain, R. K. (2011) · Physiological Reviews · doi:10.1152/physrev.00038.2010 · Cited by 1,605 · see citing works

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

Schuster, S., Svoboda, J., Chong, E., Nasta, S., Mato, A., Anak, Ö., Brogdon, J., Pruteanu-Malinici, I., Bhoj, V. G., Landsburg, D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1708566 · Cited by 1,599 · see citing works

Endothelial Activation and Blood–Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells

Gust, J., Hay, K. A., Hanafi, L.-A., Li, D., Myerson, D., Gonzalez-Cuyar, L. F., Yeung, C., Liles, W. C., Wurfel, M., Lopez, J. A., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0698 · Cited by 1,400 · see citing works

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors

De Palma, M., Venneri, M. A., Galli, R., Sergi, L. S., Politi, L. S., Sampaolesi, M., & Naldini, L. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.002 · Cited by 1,311 · see citing works

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

Du, R., Lu, K. V., Petritsch, C. K., Liu, P., Ganß, R., Passegue, E. A., Song, H., VandenBerg, S. R., Johnson, R. S., Werb, Z., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.01.034 · Cited by 1,131 · see citing works

Targeting natural killer cells in cancer immunotherapy

Guillerey, C., Huntington, N. D., & Smyth, M. J. (2016) · Nature Immunology · doi:10.1038/ni.3518 · Cited by 1,061 · see citing works

Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

Li, Y., Hermanson, D., Moriarity, B. S., & Kaufman, D. S. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.06.002 · Cited by 986 · see citing works

Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth

Cheng, L., Huang, Z., Zhou, W., Wu, Q., Donnola, S., Liu, J. K., Fang, X., Sloan, A. E., Mao, Y., Lathia, J. D., et al. (2013) · Cell · doi:10.1016/j.cell.2013.02.021 · Cited by 905 · see citing works

Toxicity and management in CAR T-cell therapy

Bonifant, C. L., Jackson, H. J., Brentjens, R. J., & Curran, K. J. (2016) · Molecular Therapy — Oncolytics · doi:10.1038/mto.2016.11 · Cited by 892 · see citing works

GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas

Majzner, R. G., Ramakrishna, S., Yeom, K. W., Patel, S., Chinnasamy, H., Schultz, L. M., Richards, R. M., Jiang, L., Barsan, V. V., Mancusi, R. A., et al. (2022) · Nature · doi:10.1038/s41586-022-04489-4 · Cited by 829 · see citing works

Human blood vessel organoids as a model of diabetic vasculopathy

Wimmer, R. A., Leopoldi, A., Aichinger, M., Wick, N., Hantusch, B., Novatchkova, M., Taubenschmid, J., Hämmerle, M., Esk, C., Bagley, J. A., et al. (2019) · Nature · doi:10.1038/s41586-018-0858-8 · Cited by 803 · see citing works

CAR-NK cells: A promising cellular immunotherapy for cancer

Xie, G., Dong, H., Liang, Y., Ham, J. D., Rizwan, R., & Chen, J. (2020) · eBioMedicine · doi:10.1016/j.ebiom.2020.102975 · Cited by 800 · see citing works

Natural killer cells in antitumour adoptive cell immunotherapy

Laskowski, T. J., Biederstädt, A., & Rezvani, K. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00491-0 · Cited by 784 · see citing works

Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer

Conlon, K. C., Lugli, E., Welles, H. C., Rosenberg, S. A., Fojo, A. T., Morris, J. C., Fleisher, T. A., Dubois, S. P., Perera, L. P., Stewart, D. M., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.57.3329 · Cited by 713 · see citing works

Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies

An, Z., Aksoy, O., Zheng, T., Fan, Q.-W., & Weiss, W. A. (2018) · Oncogene · doi:10.1038/s41388-017-0045-7 · Cited by 680 · see citing works

CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy

Pan, K., Farrukh, H., Chittepu, V. C. S. R., Xu, H., Pan, C.-X., & Zhu, Z. G. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02327-z · Cited by 671 · see citing works

CAR T cells in solid tumors: challenges and opportunities

Marofi, F., Motavalli, R., Safonov, V. A., Thangavelu, L., Yumashev, A. V., Alexander, M., Shomali, N., Chartrand, M. S., Pathak, Y., Jarahian, M., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02128-1 · Cited by 582 · see citing works

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

Dirkse, A., Golebiewska, A., Buder, T., Nazarov, P. V., Muller, A., Poovathingal, S. K., Brons, N. H. C., Leite, S., Sauvageot, N., Sarkisjan, D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09853-z · Cited by 537 · see citing works

A multi-organ chip with matured tissue niches linked by vascular flow

Ronaldson-Bouchard, K., Teles, D., Yeager, K., Tavakol, D. N., Zhao, Y., Chramiec, A., Tagore, S., Summers, M., Stylianos, S., Tamargo, M., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00882-6 · Cited by 512 · see citing works

Targeting the microenvironment in solid tumors

Belli, C., Trapani, D., Viale, G., D’Amico, P., Duso, B. A., Vigna, P. D., Orsi, F., & Curigliano, G. (2018) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2018.02.004 · Cited by 506 · see citing works

Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme

Liebner, S., Fischmann, A., Rascher, G., Duffner, F., Grote, E.-H., Kalbacher, H., & Wolburg, H. (2000) · Acta Neuropathologica · doi:10.1007/s004010000180 · Cited by 490 · see citing works

Engineering and Design of Chimeric Antigen Receptors

Guedan, S., Calderón, H., Posey, A. D., & Maus, M. V. (2018) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2018.12.009 · Cited by 452 · see citing works

Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies

Parker, K. R., Migliorini, D., Perkey, E., Yost, K. E., Bhaduri, A., Bagga, P., Haris, M., Wilson, N. E., Liu, F., Gabunia, K., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.022 · Cited by 451 · see citing works

Glioblastoma Model Using Human Cerebral Organoids

Ogawa, J., Pao, G. M., Shokhirev, M. N., & Verma, I. M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.105 · Cited by 391 · see citing works

Generation of vascularized brain organoids to study neurovascular interactions

Sun, X.-Y., Ju, X.-C., Li, Y., Zeng, P.-M., Wu, J., Zhou, Y., Shen, L., Dong, J., Chen, Y., & Luo, Z. (2022) · eLife · doi:10.7554/elife.76707 · Cited by 390 · see citing works

Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier

S. Hersh, D., S. Wadajkar, A., B. Roberts, N., G. Perez, J., P. Connolly, N., Frenkel, V., A. Winkles, J., F. Woodworth, G., & J. Kim, A. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666151221150733 · Cited by 387 · see citing works

ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma

Zhang, C., Burger, M. C., Jennewein, L., Genßler, S., Schönfeld, K., Zeiner, P. S., Hattingen, E., Harter, P. N., Mittelbronn, M. G. A., Tonn, T., et al. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv375 · Cited by 387 · see citing works

Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication

Picollet-D’hahan, N., Żuchowska, A., Lemeunier, I., & Gac, S. L. (2021) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.11.014 · Cited by 384 · see citing works

HER2-Specific T Cells Target Primary Glioblastoma Stem Cells and Induce Regression of Autologous Experimental Tumors

Ahmed, N. M., Salsman, V. S., Kew, Y., Shaffer, D. R., Powell, S. Z.-E., Zhang, Y. J., Grossman, R. G., Heslop, H. E., & Gottschalk, S. M. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1322 · Cited by 382 · see citing works

Capillary Ultrastructure and the Blood-Brain Barrier in Human Malignant Brain Tumors

Long, D. M. (1970) · Journal of neurosurgery · doi:10.3171/jns.1970.32.2.0127 · Cited by 372 · see citing works

CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells

Han, J., Chu, J., Chan, W. K., Zhang, J., Wang, Y., Cohen, J. B., Victor, A. R., Meisen, W. H., Kim, S.-H., Grandi, P., et al. (2015) · Scientific Reports · doi:10.1038/srep11483 · Cited by 342 · see citing works

Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment

Sun, X., & Yu, Q. (2015) · Acta Pharmacologica Sinica · doi:10.1038/aps.2015.92 · Cited by 321 · see citing works

Generation of blood vessel organoids from human pluripotent stem cells

Wimmer, R. A., Leopoldi, A., Aichinger, M., Kerjaschki, D., & Penninger, J. M. (2019) · Nature Protocols · doi:10.1038/s41596-019-0213-z · Cited by 317 · see citing works

A nomenclature consensus for nervous system organoids and assembloids

Pașca, S. P., Arlotta, P., Bateup, H. S., Camp, J. G., Cappello, S., Gage, F. H., Knoblich, J. A., Kriegstein, A. R., Lancaster, M. A., Ming, G., et al. (2022) · Nature · doi:10.1038/s41586-022-05219-6 · Cited by 305 · see citing works

Progress in glioma diagnosis, classification and treatment

Wen, P. Y., & Reardon, D. A. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.242 · Cited by 283 · see citing works

Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor

Barrow, A. D., Edeling, M. A., Trifonov, V., Luo, J. R., Goyal, P., Bohl, B. P., Bando, J. K., Kim, A. H., Walker, J. R., Andahazy, M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.037 · Cited by 280 · see citing works

Immunohistochemical Detection of EGFRvIII in High Malignancy Grade Astrocytomas and Evaluation of Prognostic Significance

Aldape, K., Ballman, K. V., Furth, A. F., Buckner, J. C., Giannini, C., Burger, P. C., Scheithauer, B. W., Jenkins, R. B., & James, C. D. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.7.700 · Cited by 275 · see citing works

The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy

Souza-Fonseca-Guimarães, F., Cursons, J., & Huntington, N. D. (2019) · Trends in Immunology · doi:10.1016/j.it.2018.12.003 · Cited by 269 · see citing works

Angiogenesis in Glioblastoma

Das, S., & Marsden, P. A. (2013) · New England Journal of Medicine · doi:10.1056/nejmcibr1309402 · Cited by 268 · see citing works

Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer

Sakamoto, N., Ishikawa, T., Kokura, S., Okayama, T., Oka, K., Ideno, M., Sakai, F., Kato, A., Tanabe, M., Enoki, T., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0632-8 · Cited by 267 · see citing works

Creation of bladder assembloids mimicking tissue regeneration and cancer

Kim, E., Choi, S., Kang, B., Kong, J., Kim, Y., Yoon, W., Lee, H. R., Kim, S. E., Kim, H., Lee, H. S., et al. (2020) · Nature · doi:10.1038/s41586-020-3034-x · Cited by 264 · see citing works

Targeting Glioma Stem Cell-Derived Pericytes Disrupts the Blood-Tumor Barrier and Improves Chemotherapeutic Efficacy

Zhou, W., Chen, C., Shi, Y., Wu, Q., Gimple, R. C., Fang, X., Huang, Z., Zhai, K., Ke, S. Q., Ping, Y., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.10.002 · Cited by 232 · see citing works

An Oncolytic Virus Expressing IL15/IL15Rα Combined with Off-the-Shelf EGFR-CAR NK Cells Targets Glioblastoma

Ma, R., Lu, T., Li, Z., Teng, K., Mansour, A. G., Yu, M., Tian, L., Xu, B., Ma, S., Zhang, J., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0035 · Cited by 223 · see citing works

CAR-NK cells for cancer immunotherapy: from bench to bedside

Zhang, L., Yuan, M., Feng, X., & Han, Z. (2022) · Biomarker Research · doi:10.1186/s40364-022-00364-6 · Cited by 195 · see citing works

Dual targeting of glioblastoma with chimeric antigen receptor-engineered natural killer cells overcomes heterogeneity of target antigen expression and enhances antitumor activity and survival

Genßler, S., Burger, M. C., Zhang, C., Oelsner, S., Mildenberger, I. C., Wagner, M., Steinbach, J., & Wels, W. S. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1119354 · Cited by 188 · see citing works

Constitutive and TNFα-inducible expression of chondroitin sulfate proteoglycan 4 in glioblastoma and neurospheres: Implications for CAR-T cell therapy

Pellegatta, S., Savoldo, B., Ianni, N. D., Corbetta, C., Chen, Y., Patanè, M., Sun, C., Pollo, B., Ferrone, S., DiMeco, F., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao2731 · Cited by 187 · see citing works

Glioblastoma heterogeneity at single cell resolution

Eisenbarth, D., & Wang, Y. (2023) · Oncogene · doi:10.1038/s41388-023-02738-y · Cited by 179 · see citing works

Combined Effects of Pericytes in the Tumor Microenvironment

Ribeiro, A. L., & Okamoto, O. K. (2015) · Stem Cells International · doi:10.1155/2015/868475 · Cited by 168 · see citing works

Tissue concentration of systemically administered antineoplastic agents in human brain tumors

Pitz, M. W., Desai, A. S., Grossman, S. A., & Blakeley, J. O. (2011) · Journal of Neuro-Oncology · doi:10.1007/s11060-011-0564-y · Cited by 161 · see citing works

Dissecting and rebuilding the glioblastoma microenvironment with engineered materials

Wolf, K. J., Chen, J., Coombes, J. D., Aghi, M. K., & Kumar, S. (2019) · Nature Reviews Materials · doi:10.1038/s41578-019-0135-y · Cited by 159 · see citing works

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology

Golebiewska, A., Hau, A., Oudin, A., Stieber, D., Yabo, Y. A., Baus, V., Barthelemy, V., Klein, E., Bougnaud, S., Keunen, O., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02226-7 · Cited by 159 · see citing works

A New Model for Prediction of Drug Distribution in Tumor and Normal Tissues: Pharmacokinetics of Temozolomide in Glioma Patients

Rosso, L., Brock, C. S., Gallo, J. M., Saleem, A., Price, P., Turkheimer, F., & Aboagye, E. O. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2356 · Cited by 159 · see citing works

Vascularization of Human Brain Organoids

Matsui, T. K., Tsuru, Y., Hasegawa, K., & Kuwako, K.-I. (2021) · Stem Cells · doi:10.1002/stem.3368 · Cited by 158 · see citing works

PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma

Liu, T., Ma, W., Xu, H., Huang, M., Zhang, D., He, Z., Zhang, L., Brem, S. S., O’Rourke, D. M., Gong, Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05982-z · Cited by 155 · see citing works

Organoid based personalized medicine: from bench to bedside

Li, Y., Tang, P., Cai, S., Peng, J., & Hua, G. (2020) · Cell Regeneration · doi:10.1186/s13619-020-00059-z · Cited by 138 · see citing works

Tumor-associated microglia and macrophages in glioblastoma: From basic insights to therapeutic opportunities

Wang, G., Zhong, K., Wang, Z., Zhang, Z., Tang, X., Tong, A., & Zhou, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.964898 · Cited by 130 · see citing works

Challenges and developing solutions for increasing the benefits of IL-2 treatment in tumor therapy

Skrombolas, D., & Frelinger, J. G. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.875856 · Cited by 115 · see citing works

Novel Human NK Cell Line Carrying CAR Targeting EGFRvIII Induces Antitumor Effects in Glioblastoma Cells

Murakami, T., Nakazawa, T., Natsume, A., Nishimura, F., Nakamura, M., Matsuda, R., Omoto, K., Tanaka, Y., SHIDA, Y., Park, Y.-S., et al. (2018) · Anticancer Research · doi:10.21873/anticanres.12824 · Cited by 109 · see citing works

Cancer organoid co-culture model system: Novel approach to guide precision medicine

Yuan, J., Li, X.-Y., & Yu, S.-J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1061388 · Cited by 103 · see citing works

Blood Vessel Organoids for Development and Disease

Salewskij, K., & Penninger, J. M. (2023) · Circulation Research · doi:10.1161/circresaha.122.321768 · Cited by 100 · see citing works

Human assembloids.

Kanton, S., & Pașca, S. (2022) · Development · doi:10.1242/dev.201120 · Cited by 95 · see citing works

Chimeric Antigen Receptor-Engineered Natural Killer (CAR NK) Cells in Cancer Treatment; Recent Advances and Future Prospects

Elahi, R., Heydari, A. H., Hadiloo, K., & Esmaeilzadeh, A. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10246-3 · Cited by 94 · see citing works

Recent progress of national banking project on homozygous HLA ‐typed induced pluripotent stem cells in S outh K orea

Rim, Y. A., Park, N., Nam, Y., Ham, D., Kim, J., Ha, H., Jung, J., Jung, S. M., Baek, I., Kim, S., et al. (2017) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2578 · Cited by 71 · see citing works

Organoid Technology: Current Standing and Future Perspectives

Shariati, L., Esmaeili, Y., Javanmard, S. H., Bidram, E., & Amini, A. (2021) · Stem Cells · doi:10.1002/stem.3379 · Cited by 69 · see citing works

Human epidermal growth factor receptor 2 (HER2)-specific chimeric antigen receptor (CAR) for tumor immunotherapy; recent progress

Budi, H. S., Ahmad, F. N., Achmad, H., Ansari, M. J., Mikhailova, M. V., Suksatan, W., Chupradit, S., Shomali, N., & Marofi, F. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02719-0 · Cited by 69 · see citing works

Randomized Study of Paclitaxel and Tamoxifen Deposition into Human Brain Tumors: Implications for the Treatment of Metastatic Brain Tumors

Fine, R. L., Chen, J., Balmaceda, C. M., Bruce, J. N., Huang, M., Desai, M., Sisti, M. B., McKhann, G. M., Goodman, R. R., Bertino, J., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2356 · Cited by 67 · see citing works

Advances in NK cell therapy for brain tumors

Fares, J., Davis, Z., Rechberger, J. S., Toll, S. A., Schwartz, J., Daniels, D. J., Miller, J. S., & Khatua, S. (2023) · npj Precision Oncology · doi:10.1038/s41698-023-00356-1 · Cited by 67 · see citing works

Perivascular signals alter global gene expression profile of glioblastoma and response to temozolomide in a gelatin hydrogel

Ngo, M. T., & Harley, B. A. C. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.013 · Cited by 62 · see citing works

Autologous NK cells as consolidation therapy following stem cell transplantation in multiple myeloma

Nahi, H., Chrobok, M., Meinke, S., Gran, C., Marquardt, N., Afram, G., Sütlü, T., Gilljam, M., Stellan, B., Wagner, A. K., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100508 · Cited by 55 · see citing works

Microfluidic technologies for immunotherapy studies on solid tumours

Paterson, K., Zanivan, S. R., Glasspool, R. M., Coffelt, S. B., & Zagnoni, M. (2021) · Lab on a Chip · doi:10.1039/d0lc01305f · Cited by 48 · see citing works

Cortical-blood vessel assembloids exhibit Alzheimer’s disease phenotypes by activating glia after SARS-CoV-2 infection

Kong, D., Park, K. H., Kim, D., Kim, N. G., Lee, S., Shin, N., Kook, M. G., Kim, Y. B., & Kang, K. (2023) · Cell Death Discovery · doi:10.1038/s41420-022-01288-8 · Cited by 47 · see citing works

Renaissance of armored immune effector cells, CAR-NK cells, brings the higher hope for successful cancer therapy

Marofi, F., Rahman, H. S., Thangavelu, L. P., Dorofeev, A. E., Bayas-Morejón, F., Shirafkan, N., Shomali, N., Chartrand, M. S., Jarahian, M., Vahedi, G., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02251-7 · Cited by 46 · see citing works

Pericytes in Glioblastomas: Multifaceted Role Within Tumor Microenvironments and Potential for Therapeutic Interventions

Sattiraju, A., & Mintz, A. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-16908-4_2 · Cited by 38 · see citing works

Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors

Oudin, A., Baus, V., Barthelemy, V., Fabian, C., Klein, E., Dieterle, M., Wantz, M., Hau, A., Dording, C., Bernard, A., et al. (2021) · STAR Protocols · doi:10.1016/j.xpro.2021.100534 · Cited by 37 · see citing works

Three-dimensional vascular microenvironment landscape in human glioblastoma

Cribaro, G. P., Saavedra-López, E., Romarate, L., Mitxitorena, I., Díaz, L. R., Casanova, P. V., Roig-Martínez, M., Gallego, J. M., Pérez‐Vallés, A., & Barcia, C. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01115-0 · Cited by 35 · see citing works

HER-2/neu Expression in Glioblastoma Multiforme

Haynik, D. M., Roma, A. A., & Prayson, R. A. (2007) · Applied immunohistochemistry & molecular morphology · doi:10.1097/01.pai.0000213133.09160.da · Cited by 31 · see citing works

CAR-NK cell therapy for glioblastoma: what to do next?

Xiong, Q., Zhu, J., Zhang, Y., & Deng, H. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1192128 · Cited by 30 · see citing works

KHYG-1 Cells With EGFRvIII-specific CAR Induced a Pseudoprogression-like Feature in Subcutaneous Tumours Derived from Glioblastoma-like Cells

Nakazawa, T., Murakami, T., Natsume, A., Nishimura, F., Morimoto, T., Matsuda, R., Nakamura, M., Yamada, S., Nakagawa, I., Park, Y.-S., et al. (2020) · Anticancer Research · doi:10.21873/anticanres.14304 · Cited by 20 · see citing works

Transcriptomic Profiling of 3D Glioblastoma Tumoroids for the Identification of Mechanisms Involved in Anticancer Drug Resistance

Chaicharoenaudomrung, N., Kunhorm, P., Promjantuek, W., Rujanapun, N., Heebkaew, N., Sorraksa, N., & Noisa, P. (2019) · In Vivo · doi:10.21873/invivo.11762 · Cited by 19 · see citing works

Cellular Conversations in Glioblastoma Progression, Diagnosis and Treatment

Sisakht, A. K., Malekan, M., Ghobadinezhad, F., Firouzabadi, S. N. M., Jafari, A., Mirazimi, S. M. A., Abadi, B., Shafabakhsh, R., & Mirzaei, H. (2022) · Cellular and molecular neurobiology · doi:10.1007/s10571-022-01212-9 · Cited by 17 · see citing works

Human Leukocyte Antigen Class I Pseudo-Homozygous Mesenchymal Stem Cells Derived from Human Induced Pluripotent Stem Cells

Kwon, D., Ahn, H.-J., Han, M.-J., Ji, M., Ahn, J., Seo, K., & Kang, K. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-09990-9 · Cited by 10 · see citing works

Investigating Trans-differentiation of Glioblastoma Cells in an In Vitro 3D Model of the Perivascular Niche

Hatlen, R. R., & Rajagopalan, P. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c01310 · Cited by 7 · see citing works

Progress in Nanomedicine in Neurologic Diseases

Sharma, H. S., & Sharma, A. (2023) · Advances in neurobiology · doi:10.1007/978-3-031-32997-5 · Cited by 5 · see citing works

Pericytes: jack-of-all-trades in cancer-related inflammation

Moro, M., Balestrero, F. C., & Grolla, A. A. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1426033 · Cited by 29 · see citing works

New power in cancer immunotherapy: the rise of chimeric antigen receptor macrophage (CAR-M)

Jing, J., Chen, Y., Chi, E., Li, S., He, Y., Wang, B., Shen, H., Fan, L., Wang, J., Shangguan, T., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07115-9 · Cited by 24 · see citing works

Unveiling the functional roles of patient‐derived tumour organoids in assessing the tumour microenvironment and immunotherapy

Chen, D., Xu, L., Xuan, M., Chu, Q., & Xue, C. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1802 · Cited by 20 · see citing works

CAR Beyond αβ T Cells: Unleashing NK Cells, Macrophages, and γδ T Lymphocytes Against Solid Tumors

Xian, Y., & Wen, L. (2025) · Vaccines · doi:10.3390/vaccines13060654 · Cited by 18 · see citing works

Advances in Cellular Immune Theranostic Approaches for Glioblastoma: Current Trends and Future Directions

Gong, Y., Lin, W., Fang, X., Zhang, R., Luo, M., Wu, H., Chu, S., Li, C., Peng, Y., Piao, Z., et al. (2025) · Cancer Innovation · doi:10.1002/cai2.70018 · Cited by 18 · see citing works

Natural killer cell membrane manipulation for augmented immune synapse and anticancer efficacy

Ryu, M., Kim, E., Kim, S., & Kim, K. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101965 · Cited by 13 · see citing works

Therapeutic effects of hypoimmunogenic universal human iPSC-derived endothelial cells in a humanized mouse model of peripheral artery disease

Choi, J., Kim, N. G., Kong, D., Kim, M., Kang, B.-C., Kwon, D., Kim, D., & Kang, K. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04554-5 · Cited by 12 · see citing works

Genetically stable multi-gene edited iPSCs-derived NK cells for enhanced cancer immunotherapy

Kwon, D., Moon, B. K., Han, M., Lee, T.-W., Lee, J., & Kang, K. (2024) · Molecular Therapy Oncology · doi:10.1016/j.omton.2024.200885 · Cited by 11 · see citing works

Single‐cell transcriptomic analysis of glioblastoma reveals pericytes contributing to the blood–brain–tumor barrier and tumor progression

Li, Y., Wu, C., Long, X., Wang, X., Gao, W., Deng, K., Xie, B., Zhang, S., Wu, M., & Liu, Q. (2024) · MedComm · doi:10.1002/mco2.70014 · Cited by 11 · see citing works

Cell and tissue reprogramming: Unlocking a new era in medical drug discovery

Sen, C. K., Friday, A. J., & Roy, S. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100077 · Cited by 9 · see citing works

Hypoimmunogenic CD19 CAR-NK cells derived from embryonic stem cells suppress the progression of human B-cell malignancies in xenograft animals

Zhang, Q., Xia, C., Weng, Q., Zhang, L., Wang, Y., Liu, Y., Zheng, X., Lin, Y., Chen, Y., Shen, Y., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1504459 · Cited by 8 · see citing works

Pre-Clinical Models for CAR T-Cell Therapy for Glioma

Vandecandelaere, G., Ramapriyan, R., Gaffey, M., Richardson, L. G., Steuart, S. J., Tazhibi, M., Kalaw, A., Grewal, E. P., Sun, J., Curry, W. T., et al. (2024) · Cells · doi:10.3390/cells13171480 · Cited by 7 · see citing works

Evolving from organoid to assembloid with enhanced cellular interactions

Liu, J., Shi, Y., Shen, X., Zhang, W., Wang, X., & Wang, K. (2025) · Cell organoid (Print) · doi:10.26599/co.2025.9410010 · Cited by 6 · see citing works

Modeling the metastatic tumor microenvironment: a co-culture platform of lung cancer and blood vessel organoids for drug evaluation

Lee, M., Yoon, Y.-J., Lee, J. Y., Hwang, M., Park, S., Lee, M. H., Um, S., Cho, B. C., Rheey, J., Sato, T., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-29214-9 · Cited by 5 · see citing works

Prospects and applications of NK therapy in the treatment of gliomas (Review)

Liu, Y., Su, C., Wei, X., Wei, N., Qian, Q., & Xu, Z. (2025) · Oncology Reports · doi:10.3892/or.2025.8921 · Cited by 5 · see citing works

Advancing glioblastoma immunotherapy: Molecular pathways and innovative therapeutic strategies

Tang, M., Xu, P., & Zhang, X. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156326 · Cited by 3 · see citing works

Methods and applications of patient-derived organoid models for immune microenvironment and immunotherapy research in multiple cancer types

Yu, Y., Li, Y., Wang, J., Zhu, Y.-J., Zhang, Z., Xiao, Z., Chen, Y., Qu, Y., Han, L., & Zhang, H. (2026) · Experimental Hematology and Oncology · doi:10.1186/s40164-026-00757-5 · Cited by 2 · see citing works

Culturing Potential: advances in ex vivo cell culture systems for haematopoietic cell-based regenerative therapies

Sugiyama-Finnis, A., & Yamazaki, S. (2025) · Regenerative Therapy · doi:10.1016/j.reth.2025.07.001 · Cited by 1 · see citing works

Mechanisms and strategies for reversing NK cell exhaustion in tumor immunotherapy

Zhi, L., Wang, Y., Zhao, Z., Guo, Y., Wang, K., He, W., Guo, C., Niu, Z., Zhu, W., & Zhang, X. (2026) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2026.105031 · Cited by 1 · see citing works

Evolving Landscape of Glioblastoma Research: Integrating Therapeutic Advances and Diagnostic Frontiers

Sabnis, N. A., Cooksey, L. C., Jayakumar, H., Mendez, M. M., Mathew, E., Petty, R. M., Ranjan, A. P., Colón-Pérez, L. M., Dickerman, R. D., Mathew, P. A., et al. (2026) · Brain Sciences · doi:10.3390/brainsci16050487 · Cited by 1 · see citing works

Vascularized human skin assembloids model compartmental skin organization and immune responsiveness in vitro

Kim, M.-J., Lee, S., & Kang, K.-S. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01840-x

hiPSC-Driven Organoid Construction and Application Prospects

Liu, B., Mu, Y., & Wang, D. (2025) · Regenerative medicine and dentistry. · doi:10.53941/rmd.2025.100005

Dual Challenges and Innovative Strategies in Chimeric Antigen Receptor T-cell Therapy for Glioblastoma

Zhang, L., Zhang, Z., He, J., Zhang, Z., Zhou, H., Jiang, Y., Zhong, X., Yang, Y., Li, N., Xu, W., et al. (2025) · Oncology Advances · doi:10.14218/ona.2025.00014

Clinical applications of induced pluripotent stem cell-mediated therapies in cancer: progress, challenges, and future directions

AlKhafaje, Z., Malathi, H., Dash, A., Precilla Selvakumari, J., Singh, G., Sinha, A., Suliman, M., & Smerat, A. (2026) · Regenerative Medicine · doi:10.1080/17460751.2026.2629846

Targeting immune microenvironment–mediated mesenchymal transition in glioblastoma: Molecular mechanisms and translational strategies

Liu, F., Chen, J., Yu, M., Yanlin, L., Wang, W., Pei, Y., 杨淑艳, & Yu, W. (2026) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdag075

Potential Application of CAR-NK Cells as an Ex Vivo Therapy for T-cell-related Diseases

Kwon, D., & Kang, K. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl48704

Engineering and Integrating Blood Vessel Organoids: a Comprehensive Blueprint for Physiological and Disease Modeling

Xu, Y., Wubuli, N., & Zhang, J. (2026) · Stem Cell Reviews and Reports · doi:10.1007/s12015-026-11145-1

Immunosuppressive roles of pericytes in cancer disease: insights from a systematic review and meta-analysis

Hernández-Camarero, P., Toledo, B., Diaz-Ruano, A. B., Picon‐Ruiz, M., González-Titos, A., Madeddu, R., Marchal, J. A., & Perán, M. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08216-9

Crosstalk in the brain tumor microenvironment: mechanisms, therapeutic strategies, and clinical advances

Tanzhu, G., Chen, L., Ning, J.-Y., Xiao, G., Wen, S., Wang, C., Wen, H., Zhang, K.-Q., Yang, J., Jia, M.-Y., et al. (2026) · Military Medical Research · doi:10.1016/j.mmr.2026.100047

Blood-brain barrier and blood-tumoral barrier formation in glioblastoma: endothelial cells and glioblastoma stem cells at the immune-brain crossroad

Rosito, M., Lyck, R., Engelhardt, B., & Limatola, C. (2026) · Fluids and Barriers of the CNS · doi:10.1186/s12987-026-00850-1

Immune–angiogenic crosstalk in glioblastoma: Mechanisms and therapeutic opportunities

Supty, S. I., Islam, S. M. S., Riea, A. T. M., Momin, M. A., Sadekuzzaman, M., Mow, S. I., Sabuj, M. S. S., Khasnobish, A., Roy, A. C., & Akanda, M. R. (2026) · Pathology - Research and Practice · doi:10.1016/j.prp.2026.156634

iPSC-derived CAR-NK extracellular vesicles for non-small cell lung cancer: evidence, engineering, and translational barriers

Liang, Z., Zhao, X., Jiang, M., Zhou, M., Liu, S., & Zhao, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1934758

Advances in Stem Cell Therapy for Hearing Loss

Krishnan, P. S., Jung, D., Morris, J. A., Tang, P.-C., & Liu, X. Z. (2026) · Ear and Hearing · doi:10.1097/aud.0000000000001813

Reprogramming tumor vasculature: Integrating normalization biology with vascularized tumor-on-chip models

Zaman, M., NAZARE, T., Sarkar, A., & Mirzapourshafiyi, F. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124696

Assessment of cytotoxicity of human CAR-NK cells against various canine tumor cell lines

Kang, Y., Lim, G., Kwon, D., Lee, J., Moon, B., Kang, K., Ryu, M.-O., Seo, K., & Youn, H. (2026) · Research in Veterinary Science · doi:10.1016/j.rvsc.2026.106448

Neuroimmune communication: from CNS-resident cell networks to the glioblastoma microenvironment

Li, Y., Zheng, Q., Wang, X., Fu, H., Chen, J., Yao, L., Lin, J., & Wang, R. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.2002570

Abstract 1325: CD19 CAR-expressing iPSC-derived NK cells effectively enhance migration and cytotoxicity into glioblastoma by targeting to the pericytes in tumor microenvironment

Kong, D., Kwon, D., Moon, B., Kim, D., & Kang, K. (2024) · Cancer Research · doi:10.1158/1538-7445.am2024-1325

Abstract 2177: Spatial transcriptomic and functional analysis of HLA/PD-1/CTLA4 multi-gene edited CD19 CAR-iNK cells targeting pericytes in the glioblastoma tumor microenvironment to inhibit tumor migration and growth

Kang, K. (2025) · Cancer Research · doi:10.1158/1538-7445.am2025-2177 · Cited by 1 · see citing works

Expanded NK and fratricide-resistant CD70 CAR-NK cells are potent against patient-derived glioblastoma cells in vitro and in vivo

Mehboob, M., Rätsep, M. T., Moinuddin, A., Portillo, A. L., Vahedi, F., Sookhaklari, M., Troy, E. C., Sezgin, Y., Shaikh, V., Maich, W. T., et al. (2026) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-026-04536-3

150 Targeted delivery of a PD-L1-blocking scFv by CAR-NK cells shows potential as a new approach to immunotherapy for glioblastoma

Wang, J., & Matosevic, S. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-sitc2021.150

Abstract B034: Assessing the cytotoxic potential of novel CAR-NK cells targeting glioblastoma stem cell antigens

Lima, V. A., Mitsugi, T., & Okamoto, O. K. (2024) · Cancer Immunology Research · doi:10.1158/2326-6074.tumimm24-b034 · Cited by 2 · see citing works