CoChat
Sign Up
Cited by 179Substance Abuse Treatment and OutcomesAlcohol Consumption and Health EffectsAlcoholism and Thiamine Deficiency

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Psychiatric Disorders

Petrakis, Ismene L., Poling, James, Levinson, Carolyn, Nich, Charla, Carroll, Kathleen, Rounsaville, Bruce·2005·Biological Psychiatry
DOI 10.1016/j.biopsych.2005.02.016
Open this paper in CoChat — free account

Abstract

Background Disulfiram and naltrexone are approved by the Food and Drug Administration (FDA) for the treatment of alcoholism, but these agents have not been rigorously evaluated in dually diagnosed individuals.Method Two-hundred and fifty-four patients with an Axis I psychiatric disorder and comorbid alcohol dependence were treated for 12 weeks in an outpatient medication study conducted at three Veterans Administration outpatient clinics. Randomization included assignment to one of four groups: 1) naltrexone alone; 2) placebo alone; 3) (open-label) disulfiram and (blinded) naltrexone; or 4) (open-label) disulfiram and (blinded) placebo. Medication compliance was evaluated using the Microelectric Events Monitoring System. Primary outcomes were measures of alcohol use. Secondary outcomes included psychiatric symptoms, alcohol craving, g-GGT levels and adverse events.Results There was a high rate of abstinence across groups. Subjects treated with an active medication had significantly more consecutive weeks of abstinence and less craving than those treated with placebo, but there were no significant group differences in other measures of alcohol consumption. There was no advantage of the combination of both medications.Conclusions These data suggest a modest advantage for the use of disulfiram and naltrexone for this group of dually diagnosed alcohol-dependent individuals but did not suggest an advantage in the combination.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2005.02.016

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 42 references

Cited by

Sorted by citations

Items 101–179 of 179

Related

See all

Metadata

Authors
Petrakis, I. L., Poling, J., Levinson, C., Nich, C., Carroll, K., & Rounsaville, B.
Affiliations
Yale University (US)
Corresponding author
Petrakis, Ismene L.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2005-05
Volume
57
Issue
10
Pages
1128-1137
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2005.02.016
OpenAlex
W1985702729
Cited by
177
References
42
Citations by year
2026: 3 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 11 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 10 · 2015: 6 · 2014: 14 · 2013: 12 · 2012: 13
FWCI
9.03
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (K05DA000457)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
Keywords
naltrexone, disulfiram, alcoholism, psychiatric comorbidity, veterans, alcohol craving, alcohol abstinence, combination pharmacotherapy, gamma-glutamyl transferase, medication adherence
MeSH terms
Alcohol Deterrents, Alcoholism, Mental Disorders, Disulfiram, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Naltrexone, Narcotic Antagonists, Psychiatric Status Rating Scales, Treatment Outcome, Diagnosis, Dual (Psychiatry)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review