Cited by 314Obsessive-Compulsive Spectrum DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychoanalysis and Psychopathology Research

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Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: An open-label trial

Coric, Vladimir, Taskiran, Sarper, Pittenger, Christopher, Wasylink, Suzanne, Mathalon, Daniel H., Valentine, Gerald, Saksa, John, Wu, Yu-te, Gueorguieva, Ralitza, Sanacora, Gerard, Malison, Robert T., Krystal, John H.·2005·Biological Psychiatry

DOI 10.1016/j.biopsych.2005.04.043

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Abstract

Background Most patients with obsessive-compulsive disorder (OCD) show only partial reduction of symptoms with standard therapy. Recent imaging data suggests glutamatergic dysfunction in the corticostriatal pathway in OCD. We investigated the efficacy of augmentation therapy with riluzole, a glutamate-modulating agent, in treatment-resistant OCD.Methods Thirteen patients aged between 18 and 65 years with a primary diagnosis of OCD that had proven resistant to standard treatment were treated with the addition of riluzole to their existing pharmacotherapy. Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Hamilton Depression Inventory (HAM-D), and Hamilton Anxiety Inventory (HAM-A) scores were obtained weekly.Results Thirteen treatment-resistant OCD patients received riluzole 50 mg twice a day. Y-BOCS scores improved significantly over time. Of 13 patients, 7 (54%) demonstrated a >35% reduction in Y-BOCS scores, and 5 (39%) were categorized as treatment responders. HAM-D and HAM-A scores for the group also significantly improved over time. Riluzole was well tolerated with no serious adverse effects noted.Conclusions Riluzole appears to have significant antiobsessional, antidepressant, and antianxiety properties. The addition of this agent may be of practical clinical benefit in patients with OCD.

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Energy on demand.
Magistretti, P. J., Pellerin, L., Rothman, D. L., & Shulman, R. G. (1999) · Science · doi:10.1126/science.283.5401.496 · Cited by 1,170
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Sanacora, G., Gueorguieva, R. V., Epperson, C. N., Wu, Y., Appel, M., Rothman, D. L., Krystal, J. H., & Mason, G. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.705 · Cited by 796
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Auer, D. P., Pütz, B., Kraft, E., Lipinski, B., Schill, J., & Holsboer, F. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00159-6 · Cited by 562
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(2011) · Oxford University Press eBooks · doi:10.1093/med/9780199798261.001.0001 · Cited by 523
Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13 C NMR
Shen, J., Petersen, K. F., Behar, K. L., Brown, P., Nixon, T. W., Mason, G. F., Petroff, O. A. C., Shulman, G. I., Shulman, R. G., & Rothman, D. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8235 · Cited by 462
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Cohen, J. S. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440120021003 · Cited by 430
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Urbani, A., & Belluzzi, O. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00242.x · Cited by 381
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ROSENBERG, D. R., MacMASTER, F. P., KESHAVAN, M. S., FITZGERALD, K. D., STEWART, C. M., & MOORE, G. J. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200009000-00008 · Cited by 377

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Anxiety levels and related pharmacological drug treatment: a memorandum for the third millennium.
Pasquini, M., & Berardelli, I. (2009) · PubMed · Cited by 7
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Allen, E. M., Hughes, E. F., Anderson, C. J., & Woehrle, N. S. (2018) · Behavioral Neuroscience · doi:10.1037/bne0000251 · Cited by 7
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Cardoos, A., Inamori, A., Sanacora, G., D, M. F. M., & Mischoulon, D. (2013) · Psychosomatics · doi:10.1016/j.psym.2013.02.002 · Cited by 6
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Marazziti, D., Picchetti, M., Baroni, S., Ceresoli, D., Consoli, G., & Dell’Osso, M. C. (2012) · Giornale italiano di psicopatologia/Journal of psychopathology/Italian journal of psychopathology · Cited by 5
Glutamate theory in developing novel pharmacotherapies for obsessive compulsive disorder: Focusing on N-methyl-D-aspartate signaling
Wu, P.-L., Lane, H., Tang, H., & Tsai, G. E. (2012) · Biomedicine · doi:10.1016/j.biomed.2012.04.003 · Cited by 4
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Rao, N. P., & Venkatasubramanian, G. (2015) · Springer eBooks · doi:10.1007/978-3-319-12952-5_9 · Cited by 4
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Boff, T. C., Soares, S. J. B., Lima, M. D. M., & Ignácio, Z. M. (2022) · Springer eBooks · doi:10.1007/978-3-030-87480-3_19 · Cited by 4
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Zurowski, B., Wahl, K., Hohagen, F., & Kordon, A. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.12.023 · Cited by 4
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Arnold, P. D., & Kronenberg, S. (2017) · Wiley eBooks · doi:10.1002/9781118890233.ch60 · Cited by 4
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Singer, H. S. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0435-8.00070-6 · Cited by 3
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Vega‐Dienstmaier, J. M. (2017) · Revista de Neuro-Psiquiatría · doi:10.20453/rnp.v79i4.2978 · Cited by 5
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Abdallah, S. B., Olfson, E., & Fernandez, T. V. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19176-3.00011-x · Cited by 3
Glutamate-Modulating Drugs & the Treatment of Mental Disorders
Howland, R. H. (2007) · Journal of Psychosocial Nursing and Mental Health Services · doi:10.3928/02793695-20070101-04 · Cited by 3
Novel approaches in treatment of pediatric anxiety
Park, J. M., & Geller, D. A. (2014) · F1000Prime Reports · doi:10.12703/p6-30 · Cited by 2
“Several open-label trials in adults examining riluzole as monotherapy or an adjunct therapy have resulted in significant reductions in anxiety symptoms after treatment [44,45].”
Background
Advances in Pharmacotherapy for Pediatric Anxiety Disorders
Rynn, M. A., Puliafico, A. C., Heleniak, C. M., Rikhi, P., Ghalib, K., & Vidair, H. B. (2011) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.9.3.foc299 · Cited by 2
Treatment-Resistant Obsessive-Compulsive Disorder (OCD) – Current Understanding
Mushtaq, A., Chandel, R. K., Mushtaq, H., & Mushtaq, D. (2014) · InTech eBooks · doi:10.5772/57232 · Cited by 4
Pharmacologic Protocols for Spinal Cord-Injured Athletes
Wang, S., Hawryluk, G. W. J., Spano, S., & Fehlings, M. G. (2010) · Seminars in Spine Surgery · doi:10.1053/j.semss.2010.06.010 · Cited by 2
Neurobiological Evidence Supporting Glutamate's Role in Pediatric Obsessive Compulsive Disorder
MacMaster, F. P., & Rosenberg, D. R. (2010) · Child and Adolescent Psychopharmacology News · doi:10.1521/capn.2010.15.6.6 · Cited by 3
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McClendon, J. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n1121g · Cited by 2
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Sheerin, M., & Adejare, A. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802810-0.00013-1 · Cited by 2
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Fotinos, A., Zhu, Y., Mao, L. L. J., Atassi, N., Zhou, E., Ahmad, S., Guan, Y., Berry, J. D., Cudkowicz, M., & Wang, X. (2016) · Springer eBooks · doi:10.1007/978-81-322-2803-5_51 · Cited by 2
Use of N-acetylcysteine in Obsessive-Compulsive and Related Disorders
Memik, N. Ç., Gündoğdu, Ö. Y., & Tural, Ü. (2015) · Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology · doi:10.5455/bcp.20140811064455 · Cited by 2
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Pallanti, S., Grassi, G., & Cantisani, A. (2012) · Wiley eBooks · doi:10.1002/9781119941125.ch5 · Cited by 2
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Brashear, H. R., & Spivey, J. M. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0123d · Cited by 2
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Çelik, F. G. H., & Hocaoğlu, Ç. (2024) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi:10.18863/pgy.1279927 · Cited by 2
Efficacy of glutamate-GABA modulator riluzole for the treatment of cognitive and psychotic symptoms in 22q11.2 deletion syndrome: A placebo-controlled crossover trial
Sylvester, A. L., Spapens, J. C., Soons, N., Kappert, S., Janssen, P. K. C., Ivanov, D., Zinkstok, J., Linden, D. E. J., van Amelsvoort, T., & Vingerhoets, C. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116913 · Cited by 1
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Bloch, M. H. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511973796.016 · Cited by 1
Neuroimaging Studies of Pediatric Obsessive–Compulsive Disorder: Special Emphasis on Genetics and Biomarkers
MacMaster, F. P., & Rosenberg, D. R. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9831-4_9 · Cited by 1
Augmentation of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder
Goddard, A. W., & Shin, Y. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511973796.005 · Cited by 1
P.4.d.005 Combining clomipramine and paroxetine for treatment-resistant obsessive compulsive disorder
Amodeo, G., Maina, G., Rosso, G., Viola, M., & Fagiolini, A. M. (2015) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(15)30797-5 · Cited by 1
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Hill, A. M., Cutler, J. B. R., & Robinson, K. (2019) · Cambridge University Press eBooks · doi:10.1017/9781107706866.038 · Cited by 1
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Greenberg, E., Johnson, G., & GELLER, D. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-57472-6_10 · Cited by 1
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MacMaster, F. P., & Rosenberg, D. R. (2010) · Child and Adolescent Psychopharmacology News · doi:10.1521/capn.2010.15.6.1 · Cited by 2
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Mirjalili, B. B. F., Kabnadideh, S., Zomorodian, K., Zamani, L., Faghih, M., Haghighijoo, Z., & Kananizadehgan, S. (2017) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2017/35831 · Cited by 1
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Sachdev, R. A., Ruparelia, R., Reid, J. E., Mpavenda, D., Cinosi, E., & Fineberg, N. A. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108164313.016 · Cited by 1
Zwangsstörungen
Eggers, C., & Döpfner, M. (2011) · Springer eBooks · doi:10.1007/978-3-642-19846-5_18 · Cited by 1
Zwangsstörung
Kapfhammer, H. (2011) · Springer eBooks · doi:10.1007/978-3-642-03637-8_58 · Cited by 1
Glutamate and the Treatment of Obsessive-Compulsive Disorder
&NA; (2010) · Psychopharm Review · doi:10.1097/01.idt.0000371059.45965.88 · Cited by 1
Reply to Predicting Pharmacotherapy Outcome From a Retrospective Chart Study?
Reddy, Y. C. J., & Thennarasu, K. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0123b · Cited by 1
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Costa, D. L. D. C. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2016.tde-05122016-164417 · Cited by 1
Biological Models and Treatments for OCD in Adults
Stewart, S. E., & Loh, A. S. (2017) · Wiley eBooks · doi:10.1002/9781118890233.ch14 · Cited by 1
Biological Models and Treatments for Obsessive‐Compulsive Related Disorders for Adults
Hudak, R., Borue, X., & Sharma, M. (2017) · Wiley eBooks · doi:10.1002/9781118890233.ch59 · Cited by 1
Depression and Anxiety Disorders
(2021) · Wiley eBooks · doi:10.1002/9781119870203.mpg003 · Cited by 1
Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders
Katzman, M. A., Bleau, P., Blier, P., Chokka, P. R., Kjernisted, K. D., & Ameringen, M. V. (2021) · doi:10.32920/14638581.v1 · Cited by 1
Using Our Understanding of Stress-Related Effects on Glutamate Neurotransmission to Guide the Development of Novel Treatment Strategies
Kiselycznyk, C., & Sanacora, G. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1056-4_17
Obsessive–Compulsive and Related Disorders: Obsessive–Compulsive Disorder and Hoarding Disorder
Pato, M. T., Steketee, G. S., Eisen, J. L., Yip, A. G., & Phillips, K. A. (2015) · Wiley eBooks · doi:10.1002/9781118753378.ch57
Molecular Genetics of Tourette Syndrome
Valenti, A. M., & Grados, M. A. (2012) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0022494
Predicting pharmacotherapy outcome from a retrospective chart study?
de Bruijn, C., Denys, D., Reddy, Y. J. J., & Kandavel, T. (2007) · Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0123a
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Misri, S. K., Reebye, P. N., Corral, M. R., & Milis, L. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n1121h
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Hein, J. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n1121c
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McCall, W. V. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0123c
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Anders, J. L. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n1121b
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Nelson, M. W., & Buchanan, R. W. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0123e
[Therapeutic strategies for obsessive-compulsive disorder refractory to treatment].
Mussa, A. (2008) · PubMed
Dysregulated ERK signal pathway and immune profiles in Fragile X Syndrome
Weng, N. (2012) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
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Weizman, R., Rodriguiz, R. M., Trotta, N. C., Peça, J., Jd, D., Sm, D., Rj, W., & Wetsel, W. C. (2009)
Argumentación del tratamiento psicofarmacológico y biológico en el trastorno obsesivo-compulsivo resistente y refractario of psychopharmacological treatments and biological in obsessive-compulsive disorder resistant and refractory
Rodríguez, T. M. (2011)
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Scarff, J. R. (2014) · The Internet Journal of Psychiatry
Zwangsstörungen (ICD-10 F4)
Voderholzer, U., & Hohagen, F. (2009) · Elsevier eBooks · doi:10.1016/b978-3-437-24900-6.50016-2
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Rodríguez, C. I., & Dakwar, E. (2016) · Springer eBooks · doi:10.1007/978-3-319-42925-0_9
A Genetic Association Study of Glutamate Transporter Genes SLC1A1 and SLC1A3 in Tourette Syndrome and Attention-Deficit/Hyperactivity Disorder
Kentebe, A. (2014) · TSpace (University of Toronto)
Psychological therapies versus pharmacotherapy for obsessive compulsive disorder (OCD)
Veronese, A., Hunot, V., Cipriani, A., Churchill, R., & Barbui, C. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007319.pub2
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Zwangsstörung
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(2017) · Elsevier eBooks · doi:10.1016/b978-3-437-24909-9.16001-3
Psychological therapies versus pharmacotherapy for obsessive compulsive disorder
Veronese, A., Hunot, V., Cipriani, A., Churchill, R. C., & Barbui, C. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007319
Faculty Opinions recommendation of Behavioral and synaptic alterations relevant to obsessive-compulsive disorder in mice with increased EAAT3 expression.
Shavitt, R. G. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734828533.793580434
Literaturverzeichnis zu Voderholzer/Hohagen (Hrsg.): Therapie psychischer Erkrankungen, 14. Auflage
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Literaturverzeichnis zu Voderholzer, Hohagen (Hrsg.): Therapie psychischer Erkrankungen, 10. Auflage
(2014) · Elsevier eBooks · doi:10.1016/b978-3-437-24906-8.16001-6
Bibliographie
(2007) · Elsevier eBooks · doi:10.1016/b978-2-294-70195-5.50010-4
Nutritional Deficiencies in Obsessive-Compulsive Disorder and Possible Treatment Interventions
Sethi, P., Kumar, S., Prajapati, A., Irfanullah, Z., Jatchavala, C., Vadivel, R., & Hayek, S. E. (2022) · Nutritional neurosciences · doi:10.1007/978-981-19-5021-6_9

Authors: Coric, V., Taskiran, S., Pittenger, C., Wasylink, S., Mathalon, D. H., Valentine, G., Saksa, J., Wu, Y.-T., Gueorguieva, R., Sanacora, G., Malison, R. T., & Krystal, J. H.
Affiliations: Yale University (US)
ORCID: Taskiran, Sarper
Pittenger, Christopher
Mathalon, Daniel H.
Valentine, Gerald
Wu, Yu-te
Gueorguieva, Ralitza
Sanacora, Gerard
Malison, Robert T.
Krystal, John H.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2005-09
Volume: 58
Issue: 5
Pages: 424-428
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2005.04.043
OpenAlex: W1982538263
Cited by: 314
References: 25
Citations by year: 2026: 7 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 4 · 2021: 10 · 2020: 8 · 2019: 12 · 2018: 5 · 2017: 15 · 2016: 15 · 2015: 21 · 2014: 21 · 2013: 22 · 2012: 23
FWCI: 25.07
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k05aa014906-03)
National Institute on Alcohol Abuse and Alcoholism (K05 AA 14906-01)
National Center for Research Resources (M01RR000125, M01 RR-00125)
Topics: Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords: riluzole, treatment-resistant OCD, augmentation therapy, glutamate modulation, glutamatergic dysfunction, corticostriatal pathway, antidepressant effects, anxiolytic effects, adverse effects
MeSH terms: Adult, Drug Resistance, Female, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder, Time Factors, Treatment Outcome, Excitatory Amino Acid Antagonists, Riluzole

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Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: An open-label trial

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