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Open accessAbstract
New imaging techniques can see into the functioning brain, revealing the regions that are active during certain tasks and sensations. Magistretti et al., in their Perspective, take this notion one step further and, by careful analysis of the biochemistry that gives rise to imaging signals, they deduce some of the cellular and molecular events that accompany neuronal activity in the working brain, ultimately laying the groundwork for determining the biochemistry that underlies human cognition.
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Total glucose use by neurons and astrocytes together is coupled directly to glutamate-mediated synaptic transmission, which accounts for 80-90% of total glucose use in the cerebral cortex.
“As a consequence, the total glucose use by neurons and astrocytes together is coupled directly to glutamate-mediated synaptic transmission [32], [34], [36], which accounts for 80–90% of total glucose use in the cerebral cortex [32].”
From Scaling of Brain Metabolism with a Fixed Energy Budget per Neuron: Implications for Neuronal Activity, Plasticity and Evolution (2011) · cites this paper as [34]
Increasing size of a neuronal cell, including all arborizations, should impose a higher metabolic demand related to the cost of maintaining membrane polarization, and energy metabolism is coupled to synaptic activity.
“Given that the increasing size of a neuronal cell (including all of its arborizations) should impose a higher metabolic demand related to the cost of maintaining membrane polarization [23] and that energy metabolism is coupled to synaptic activity [34]”
From Scaling of Brain Metabolism with a Fixed Energy Budget per Neuron: Implications for Neuronal Activity, Plasticity and Evolution (2011) · cites this paper as [34]
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- Authors
- Magistretti, P. J., Pellerin, L., Rothman, D. L., & Shulman, R. G.
- Affiliations
- University of Lausanne (CH)
- Yale University (US)
- Venue
- Science
- Published
- 1999-01-22
- Volume
- 283
- Issue
- 5401
- Pages
- 496-497
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1772857860
- Cited by
- 1,170
- References
- 7
- Citations by year
- 2026: 13 · 2025: 11 · 2024: 10 · 2023: 10 · 2022: 26 · 2021: 34 · 2020: 22 · 2019: 19 · 2018: 20 · 2017: 30 · 2016: 34 · 2015: 26 · 2014: 44 · 2013: 41 · 2012: 43
- FWCI
- 24.58
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- brain energy metabolism, neuronal activity, functional neuroimaging, neurochemistry, cognitive function
- MeSH terms
- Adenosine Triphosphate, Animals, Astrocytes, Behavior, Animal, Brain, Brain Mapping, Cognition, Energy Metabolism, Glucose, Glutamine, Magnetic Resonance Imaging, Synaptic Transmission, Neurons, Oxidation-Reduction, Sodium, Synapses, Tomography, Emission-Computed, Neurotransmitter Agents, Glutamic Acid
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