The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Monoamine Oxidase-A Genetic Variations Influence Brain Activity Associated with Inhibitory Control: New Insight into the Neural Correlates of Impulsivity
Abstract
Background Previous evidence has shown that genetic variations in the serotonergic system contribute to individual differences in personality traits germane to impulse control. The monoamine oxidase-A (MAO-A) gene, coding for an enzyme primarily involved in serotonin and noradrenaline catabolism, presents a well-characterized functional polymorphism consisting of a variable number of tandem repeats in the promoter region, with high-activity and low-activity variants. High-activity allele carriers have higher enzyme expression, lower amine concentration, and present higher scores on behavioral measures of impulsivity than low-activity allele carriers.Methods We studied the relationship of this polymorphism to brain activity elicited by a response inhibition task (Go/NoGo task), using blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging in 24 healthy men.Results Direct comparison between groups revealed a greater BOLD response in the right ventrolateral prefrontal cortex (Brodmann's area [BA] 45/47) in high-activity allele carriers, whereas a greater response in the right superior parietal cortex (BA 7) and bilateral extrastriate cortex (BA 18) was found in low-activity allele carriers.Conclusions These data suggest that a specific genetic variation involving serotonergic catabolism can modulate BOLD response associated with human impulsivity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Polymorphisms of the MAO-A gene, which increase MAO-A activity, were associated with increased activity in the right IFG and ACC and decreased activity in the superior parietal cortex during action restraint (Passamonti et al., 2006).”
From Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders (2014) · cites this paper as Passamonti et al., 2006
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527
Manual for the Wechsler Adult Intelligence Scale.
Wechsler, D. (1955) · Psychological Corp. eBooks · Cited by 4,941
Role of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842
Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00035-7 · Cited by 3,888
Inhibition and the right inferior frontal cortex
Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.02.010 · Cited by 3,197
Serotonin transporter genetic variation and the response of the human amygdala.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340
Self-citationRight hemispheric dominance of inhibitory control: An event-related functional MRI study
Garavan, H., Ross, T. J., & Stein, E. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8301 · Cited by 1,394
Localization of a human system for sustained attention by positron emission tomography
Pardo, J. V., Fox, P. T., & Raichle, M. E. (1991) · Nature · doi:10.1038/349061a0 · Cited by 1,284
Cited by
Sorted by citations
Fifty years of the Barratt Impulsiveness Scale: an update and review
Stanford, M. S., Mathias, C. W., Dougherty, D. M., Lake, S. L., Anderson, N. E., & Patton, J. H. (2009) · Personality and Individual Differences · doi:10.1016/j.paid.2009.04.008 · Cited by 1,609
Verdejo‐García, A., Lawrence, A. J., & Clark, L. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.11.003 · Cited by 1,502
Neurocognitive endophenotypes of impulsivity and compulsivity: Towards dimensional psychiatry
Robbins, T. W., Gillan, C. M., Smith, D. G., de Wit, S., & Ersche, K. D. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.11.009 · Cited by 1,003
Neural mechanisms of genetic risk for impulsivity and violence in humans
Meyer-Lindenberg, A., Buckholtz, J. W., Kolachana, B., R. Hariri, A., Pezawas, L., Blasi, G., Wabnitz, A., Honea, R., Verchinski, B., Callicott, J. H., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511311103 · Cited by 876
Left inferior frontal gyrus is critical for response inhibition
Swick, D., Ashley, V., & Turken, A. U. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-102 · Cited by 745
Metadata
- Authors
- Passamonti, L., Fera, F., Magariello, A., Cerasa, A., Gioia, M. C., Muglia, M., Nicoletti, G., Gallo, O., Provinciali, L., & Quattrone, A.
- Affiliations
- Marche Polytechnic University (IT)
- Institute of Neurological Sciences (IT)
- Magna Graecia University (IT)
- Corresponding author
- Fera, Francesco
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 59
- Issue
- 4
- Pages
- 334-340
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2047503618
- Cited by
- 167
- References
- 54
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 4 · 2021: 2 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 10 · 2015: 6 · 2014: 10 · 2013: 5 · 2012: 13
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- monoamine oxidase A, MAOA gene, variable number tandem repeats, impulsivity, inhibitory control, response inhibition, go/no-go task, ventrolateral prefrontal cortex, serotonergic system, neural correlates, genetic polymorphism, BOLD signal
- MeSH terms
- Adolescent, Adult, Alleles, Brain, Brain Mapping, DNA, Genotype, Humans, Impulsive Behavior, Magnetic Resonance Imaging, Male, Monoamine Oxidase, Oxygen, Polymorphism, Genetic, Genetic Variation, Visual Cortex, Prefrontal Cortex, Minisatellite Repeats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
