Effects of D-Cycloserine on Extinction: Consequences of Prior Exposure to Imipramine
Abstract
Background D-cycloserine (DCS), a partial N-methyl-D-aspartate (NMDA) agonist, facilitates the extinction of conditioned fear in animals and promotes the efficacy of exposure-based therapies in humans. The current study examined whether pre-exposure to the antidepressant imipramine affects the enhancement of extinction by DCS.Methods Twenty-nine rats were pre-exposed to saline, DCS, or imipramine for 14 days. The next day they were given five noise-shock pairings. The day after training, rats received six extinction trials and were then injected with DCS. At test the following day, freezing elicited by the noise was measured.Results Rats pre-exposed to either DCS or imipramine exhibited more freezing at test than rats pre-exposed to saline.Conclusions Chronic exposure to either DCS or imipramine prevents the facilitating effect of DCS on extinction. This result suggests that DCS may not effectively enhance loss of fear in patients who are also being treated with antidepressants.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Prior studies reported that extinction enhancement following DCS was attenuated in rats pre-treated with 14 days of DCS or imipramine.
“prior studies have reported that extinction enhancement following DCS was attenuated in rats pre-treated with 14 days of DCS or imipramine (Werner-Seidler and Richardson, 2007)”
From D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: a pilot randomized clinical trial (2014) · cites this paper as Werner-Seidler and Richardson, 2007
Cites
Comorbidity of anxiety and unipolar mood disorders
Mineka, S., Watson, D., & Clark, L. A. (1998) · Annual Review of Psychology · doi:10.1146/annurev.psych.49.1.377 · Cited by 1,573 · see citing works
Crouching as an index of fear.
Blanchard, R. J., & Blanchard, D. C. (1969) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0026779 · Cited by 1,077 · see citing works
Ressler, K. J., Rothbaum, B. O., Tannenbaum, L., Anderson, P., Graap, K., Zimand, E., Hodges, L., & Davis, M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.11.1136 · Cited by 1,063 · see citing works
Neural organization of the defensive behavior system responsible for fear
Fanselow, M. S. (1994) · Psychonomic Bulletin & Review · doi:10.3758/bf03210947 · Cited by 1,000 · see citing works
Behavioral and Neural Analysis of Extinction
Myers, K. M., & Davis, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01064-4 · Cited by 918 · see citing works
Walker, D. L., Ressler, K. J., Lu, K.-T., & Davis, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02343.2002 · Cited by 815 · see citing works
Anxiety and depression : distinctive and overlapping features
Kendall, P. C., & Watson, D. (1989) · Academic Press eBooks · Cited by 697 · see citing works
Augmentation of Exposure Therapy With D-Cycloserine for Social Anxiety Disorder
Hofmann, S. G., Meuret, A. E., Smits, J. A. J., Simon, N. M., Pollack, M. H., Eisenmenger, K., Shiekh, M., & Otto, M. W. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.3.298 · Cited by 560 · see citing works
Effects of D-Cycloserine on Extinction: Translation From Preclinical to Clinical Work
Davis, M., Ressler, K., Rothbaum, B. O., & Richardson, R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.084 · Cited by 498 · see citing works
Self-citationEffects of D-cycloserine on extinction of conditioned freezing.
Ledgerwood, L., Richardson, R., & Cranney, J. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.2.341 · Cited by 388 · see citing works
Self-citationAdaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.
Paul, I. A., Nowak, G., Layer, R. T., Popik, P., & Skolnick, P. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38715-x · Cited by 241 · see citing works
Nowak, G., Trullás, R., Layer, R. T., Skolnick, P., & Paul, I. A. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38235-2 · Cited by 196 · see citing works
Camerino, D. C., Tricarico, D., & Desaphy, J. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.01.013 · Cited by 162 · see citing works
Effects of multiple exposures to d-cycloserine on extinction of conditioned fear in rats
Parnas, A. S., Weber, M. F., & Richardson, R. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.01.001 · Cited by 146 · see citing works
Self-citationThe anxiety and depressive disorders: Descriptive psychopathology and differential diagnosis.
Clark, L. A. (1989) · Cited by 140 · see citing works
Yang, Y.-L., & Lu, K. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.04.003 · Cited by 93 · see citing works
Influence of ethanol withdrawal on fear memory: Effect of d-cycloserine
Bertotto, M. E., Bustos, S. G., Molina, V. A., & Martijena, I. D. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.013 · Cited by 70 · see citing works
(1998) · doi:10.1093/oso/9780198523604.001.0001 · Cited by 36 · see citing works
Manipulations of 5-HT activity and memory in the rat
Lalonde, R., & Vīķis-Freibergs, V. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90035-8 · Cited by 33 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy
Norberg, M. M., Krystal, J. H., & Tolin, D. F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.012 · Cited by 510 · see citing works
Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.004 · Cited by 390 · see citing works
Mataix-Cols, D., Fernández de la Cruz, L., Monzani, B., Rosenfield, D., Andersson, E., Pérez-Vigil, A., Frumento, P., de Kleine, R. A., Difede, J., Dunlop, B. W., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.3955 · Cited by 288 · see citing works
Difede, J., Cukor, J., Wyka, K., Olden, M., Hoffman, H., Lee, F. S., & Altemus, M. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.317 · Cited by 212 · see citing works
D-Cycloserine in Neuropsychiatric Diseases: A Systematic Review
Schade, S., & Paulus, W. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv102 · Cited by 135 · see citing works
Enhancement of psychosocial treatment with D-cycloserine: Models, moderators, and future directions
Otto, M. W., Kredlow, M. A., Smits, J. A. J., Hofmann, S. G., Tolin, D. F., de Kleine, R. A., van Minnen, A., Evins, A. E., & Pollack, M. H. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.09.007 · Cited by 70 · see citing works
A precision medicine approach to pharmacological adjuncts to extinction: A call to broaden research
King, G., Baker, K. D., Bisby, M. A., Chan, D., Cowan, C. S. M., Stylianakis, A. A., Zimmermann, K. S., & Richardson, R. (2019) · Psychopharmacology · doi:10.1007/s00213-018-4999-0 · Cited by 6 · see citing works
Self-citation
- Authors
- Werner-Seidler, A., & Richardson, R.
- Affiliations
- UNSW Sydney (AU)
- Corresponding author
- Richardson, Rick
- ORCID
- Richardson, Rick
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 62
- Issue
- 10
- Pages
- 1195-1197
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2155085503
- Cited by
- 43
- References
- 19
- Citations by year
- 2022: 1 · 2021: 1 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 8 · 2012: 3
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- D-cycloserine, fear extinction, imipramine, NMDA receptor agonist, freezing behavior, exposure therapy
- MeSH terms
- Analysis of Variance, Animals, Antidepressive Agents, Tricyclic, Antimetabolites, Behavior, Animal, Cycloserine, Extinction, Psychological, Imipramine, Male, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
