Alcoholism, corticotropin-releasing factor, and molecular genetic allostasis

Addiction and the brain antireward system

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Allostasis: A New Paradigm to Explain Arousal Pathology

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Handbook of Life Stress, Cognition and Health

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Handbook of Life Stress, Cognition and Health

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Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats

Funk, C. K., O'Dell, L. E., Crawford, E. F., & Koob, G. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3096-06.2006 · Cited by 381 · see citing works

Additive Effect of Stress and Drug Cues on Reinstatement of Ethanol Seeking: Exacerbation by History of Dependence and Role of Concurrent Activation of Corticotropin-Releasing Factor and Opioid Mechanisms

Liu, X., & Weiss, F. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-07856.2002 · Cited by 359 · see citing works

Corticotropin-Releasing Factor in Brain: A Role in Activation, Arousal, and Affect Regulation

Heinrichs, S. C., & Koob, G. F. (2004) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.052092 · Cited by 353 · see citing works

Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence

Sommer, W. H., Rimondini, R., Hansson, A. C., Hipskind, P. A., Gehlert, D. R., Barr, C. S., & Heilig, M. A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.01.010 · Cited by 309 · see citing works

Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats

Funk, C. K., Zorrilla, E. P., Lee, M.-J., Rice, K. C., & Koob, G. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.063 · Cited by 276 · see citing works

Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress

Hansson, A. C., Cippitelli, A., Sommer, W. H., Fedeli, A., Björk, K., Soverchia, L., Terasmaa, A., Massi, M. N., Heilig, M. A., & Ciccocioppo, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604419103 · Cited by 251 · see citing works

Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use

Blomeyer, D., Treutlein, J., Esser, G., Schmidt, M. H., Schumann, G., & Laucht, M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.026 · Cited by 211 · see citing works

High-priority communication I Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence

Valdez, G. R., Zorrilla, E. P., Roberts, A. J., & Koob, G. F. (2003) · Alcohol · doi:10.1016/s0741-8329(03)00020-x · Cited by 186 · see citing works

Hazardous drinking and alcohol use disorders

MacKillop, J. M., Agabio, R., Ewing, S. W. F., Heilig, M. A., Kelly, J. F., Leggio, L., Lingford-Hughes, A. R., Palmer, A. A., Parry, C. D. H., Ray, L. A., et al. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00406-1 · Cited by 235 · see citing works

Mindfulness-Oriented Recovery Enhancement versus CBT for co-occurring substance dependence, traumatic stress, and psychiatric disorders: Proximal outcomes from a pragmatic randomized trial

Garland, E. L., Roberts-Lewis, A., Tronnier, C. D., Graves, R., & Kelley, K. (2016) · Behaviour Research and Therapy · doi:10.1016/j.brat.2015.11.012 · Cited by 173 · see citing works

Therapeutic utility of non-peptidic CRF1 receptor antagonists in anxiety, depression, and stress-related disorders: Evidence from animal models

Kehne, J. H., & Cain, C. K. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.08.011 · Cited by 104 · see citing works

Application of Human Laboratory Models to Pharmacotherapy Development for Alcohol Dependence

Ray, L. A., Hutchison, K. E., & Tartter, M. A. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210791516422 · Cited by 45 · see citing works

Role of hypothalamic corticotropin-releasing factor in mediating alcohol-induced activation of the rat hypothalamic–pituitary–adrenal axis

RIVIER, C. L. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.10.005 · Cited by 43 · see citing works

The CRHR1 gene, trauma exposure, and alcoholism risk: a test of G × E effects

Ray, L. A., Sehl, M. E., Bujarski, S., Hutchison, K. E., Blaine, S. K., & Enoch, M. (2013) · Genes Brain & Behavior · doi:10.1111/gbb.12032 · Cited by 36 · see citing works

Stressful Life Events and Relapse Among Formerly Alcohol Dependent Adults

Pilowsky, D. J., Keyes, K. M., Geier, T. J., Grant, B. F., & Hasin, D. S. (2013) · Social Work in Mental Health · doi:10.1080/15332985.2012.711278 · Cited by 35 · see citing works

Gene–environment interactions resulting in risk alcohol drinking behaviour are mediated by CRF and CRF1

Clarke, T., & Schumann, G. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.04.014 · Cited by 32 · see citing works

Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling

Darlington, T. M., McCarthy, R. D., Cox, R. J., Miyamoto-Ditmon, J., Gallego, X., & Ehringer, M. A. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12294 · Cited by 23 · see citing works

Chemogenetic inhibition of corticotropin-releasing factor neurons in the central amygdala alters binge-like ethanol consumption in male mice.

Marshall, S. A., Robinson, S. L., Ebert, S. E., Companion, M. A., & Thiele, T. E. (2022) · Behavioral Neuroscience · doi:10.1037/bne0000522 · Cited by 7 · see citing works

Bio-Behavioral Indices of Emotion Regulation: Potential Targets for Treatment in Addiction

Fox, H. C., Karim, A., & Syed, S. A. (2020) · Current Addiction Reports · doi:10.1007/s40429-020-00330-y · Cited by 4 · see citing works

Single-cell whole-brain imaging and network analysis provide evidence of the three-stage hypothesis of addictionPreprint

Kimbrough, A., Lurie, D. J., Collazo, A., Kreifeldt, M., Sidhu, H., D’Esposito, M., Contet, C., & George, O. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/471847 · Cited by 2 · see citing works

Antagonists of the stress and opioid systems restore the functional connectivity of the prefrontal cortex during alcohol withdrawal through divergent mechanismsPreprint

Carrette, L. L. G., Santos, A. V. S., Brennan, M., Othman, D., Collazo, A., & George, O. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.30.560339 · Cited by 2 · see citing works

Rola endogennych neuropeptydów w patomechanizmie uzależnienia alkoholowego* Role of endogenous neuropeptides in the pathomechanism of alcohol addiction

Zalewska-Kaszubska, J. (2009)

A key role for corticotropin-releasing factor in alcohol dependence

Heilig, M., & Koob, G. F. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.006 · Cited by 503 · see citing works

Gene–environment interactions resulting in risk alcohol drinking behaviour are mediated by CRF and CRF1

Clarke, T., & Schumann, G. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.04.014 · Cited by 32 · see citing works

CRF modulation in VTA-DRN escalates alcohol intake after social stress

Miczek, K. A. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.02.233

Tackling the Link Between Stress and Alcohol

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Stress and Drink

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