The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Pharmacogenetic Randomized Trial for Cocaine Abuse: Disulfiram and Dopamine β-Hydroxylase
Open accessAbstract
Background Disulfiram has been an effective cocaine addiction pharmacotherapy, and one of its possible mechanisms of efficacy is through copper chelation and inhibition of an enzyme involved in catecholamine metabolism, dopamine β-hydroxylase (DβH), which converts dopamine to norepinephrine. A variant in the gene encoding DβH leads to reduced DβH activity, and as such, disulfiram might not be an effective treatment of cocaine dependence for individuals with this variant. This study explored that potential matching. Methods Seventy-four cocaine- and opioid-codependent (DSM-V) subjects were stabilized on methadone for 2 weeks and subsequently randomized into disulfiram (250 mg/day, n = 34) and placebo groups (n = 40) for 10 weeks. We genotyped the DBH gene polymorphism, -1021C/T (rs1611115), that reduces DβH enzyme levels and evaluated its role for increasing cocaine free urines with disulfiram. Results With repeated measures analysis of variance, corrected for population structure, disulfiram pharmacotherapy reduced cocaine-positive urines from 80% to 62% (p = .0001), and this disulfiram efficacy differed by DBH genotype group. Patients with the normal DβH level genotype dropped from 84% to 56% on disulfiram (p = .0001), whereas those with the low DBH level genotype showed no disulfiram effect. Conclusions This study indicates that the DBH genotype of a patient could be used to identify a subset of individuals for which disulfiram treatment might be an effective pharmacotherapy for cocaine dependence.
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“the findings of clinical trials (NCT00729300, NCT00149630, NCT00913484) provide limited support for the efficacy of DIS for reducing cocaine dependence.35,36,37”
From Off-label and repurposed use of disulfiram beyond alcohol dependence: A systematic review of clinical and preclinical evidence (2026) · cites this paper as [36]
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3 retracted
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RetractedCarbamazepine for cocaine dependence
Reisser, A. A. L., Lima, M., Soares, B., & Farrell, M. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002023 · Cited by 45
RetractedDopamine agonists for cocaine dependence
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Cocaïne, amphétamines et autres stimulants
Karila, L., & Benyamina, A. (2023) · Elsevier eBooks · doi:10.1016/b978-2-294-77934-3.00015-9
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Metadata
- Authors
- Kosten, T. R., Wu, G., Huang, W., Harding, M. J., Hamon, S. C., Lappalainen, J., & Nielsen, D. A.
- Affiliations
- Michael E. DeBakey VA Medical Center (US)
- Rockefeller University (US)
- Yale University (US)
- Corresponding author
- Nielsen, David A.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 73
- Issue
- 3
- Pages
- 219-224
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC3514624
- OpenAlex
- W2092220167
- Cited by
- 108
- References
- 80
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 8 · 2015: 15 · 2014: 14 · 2013: 13
- FWCI
- 15.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (P50DA018197)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- disulfiram, cocaine dependence, dopamine beta-hydroxylase, pharmacogenetics, methadone maintenance treatment, copper chelation, catecholamine metabolism, treatment response
- MeSH terms
- Adult, Disulfiram, Dopamine beta-Hydroxylase, Drug Therapy, Combination, Female, Genotype, Humans, Male, Methadone, Middle Aged, Opioid-Related Disorders, Treatment Outcome, Cocaine-Related Disorders, Polymorphism, Single Nucleotide
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