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Cited by 166

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Does a Shared Neurobiology for Foods and Drugs of Abuse Contribute to Extremes of Food Ingestion in Anorexia and Bulimia Nervosa?

Open access
Kaye, Walter H., Wierenga, Christina E., Bailer, Ursula F., Simmons, Alan N., Wagner, Angela, Bischoff-Grethe, Amanda·2013·Biological Psychiatry
DOI 10.1016/j.biopsych.2013.01.002
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Abstract

Is starvation in anorexia nervosa (AN) or overeating in bulimia nervosa (BN) a form of addiction? Alternatively, why are individuals with BN more vulnerable and AN protected from substance abuse? Such questions have been generated by recent studies that suggest that there are overlapping neural circuits for foods and drugs of abuse. In order to determine whether a shared neurobiology contributes to eating disorders (EDs) and substance abuse, this review focused on imaging studies that investigated response to tastes of food and tasks designed to characterize reward and behavioral inhibition in AN and BN. BN and those with substance abuse disorders may share dopamine D2 receptor related vulnerabilities, and opposite findings may contribute to “protection” from substance abuse in AN. Moreover, imaging studies provide insights into executive cortico-striatal processes related to extraordinary inhibition and self-control in AN and diminished inhibitory self-control in BN that may influence the rewarding aspect of palatable foods and likely other consummatory behaviors. AN and BN tend to have premorbid traits, such as perfectionism and anxiety that make them vulnerable to employing extremes of food ingestion which serve to reduce negative mood states. Dysregulation within and/or between limbic and executive cortio-striatal circuits contributes to such symptoms. Limited data support the hypothesis that reward and inhibitory processes may contribute to symptoms in ED and addictive disorders, but little is known about the molecular biology of such mechanisms in terms of shared or independent processes.

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Metadata

Authors
Kaye, W. H., Wierenga, C. E., Bailer, U. F., Simmons, A. N., Wagner, A., & Bischoff-Grethe, A.
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2013-05
Volume
73
Issue
9
Pages
836-842
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2013.01.002
OpenAlex
W1983510054
Cited by
166
References
29
FWCI
21.87
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Does a Shared Neurobiology for Foods and Drugs of Abuse Contribute to Extremes of Food Ingestion in Anorexia and Bulimia Nervosa? https://app.cochat.ai/papers/10.1016/j.biopsych.2013.01.002
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Kaye, W. H., Wierenga, C. E., Bailer, U. F., Simmons, A. N., Wagner, A., & Bischoff-Grethe, A. (2013). Does a Shared Neurobiology for Foods and Drugs of Abuse Contribute to Extremes of Food Ingestion in Anorexia and Bulimia Nervosa? Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2013.01.002

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.