Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior

The Mouse Brain in Stereotaxic Coordinates

Paxinos, G. (2001) · Cited by 12,859

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Hong, S., Beja-Glasser, V. F., Nfonoyim, B. M., Frouin, A., Li, S., Ramakrishnan, S., Merry, K. M., Shi, Q., Rosenthal, A., Barres, B. A., et al. (2016) · Science · doi:10.1126/science.aad8373 · Cited by 3,343

Stress signalling pathways that impair prefrontal cortex structure and function

Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299

The molecular neurobiology of depression

Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543

The State of US Health, 1990-2010: Burden of Diseases, Injuries, and Risk Factors

Murray, C. J. L. (2013) · JAMA · doi:10.1001/jama.2013.13805 · Cited by 2,438

Common cellular and molecular mechanisms and interactions between microglial activation and aberrant neuroplasticity in depression

Guo, X., Rao, Y., Mao, R., Cui, L., & Fang, Y. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108336 · Cited by 35

Chemogenetic Inhibition of Infralimbic Prefrontal Cortex GABAergic Parvalbumin Interneurons Attenuates the Impact of Chronic Stress in Male Mice

Nawreen, N., Cotella, E. M., Morano, R. L., Mahbod, P., Dalal, K. S., Fitzgerald, M. E., Martelle, S. E., Packard, B. A., Franco, A. C. G., Moloney, R. D., et al. (2020) · eNeuro · doi:10.1523/eneuro.0423-19.2020 · Cited by 35

CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation

Chen, X., Cui, Q., Hu, X.-H., Ye, J., Liu, Z.-C., Mei, Y.-X., Wang, F., Hu, Z., & Chen, J. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02836-4 · Cited by 33

Evidence for Similar Prefrontal Structural and Functional Alterations in Male and Female Rats Following Chronic Stress or Glucocorticoid Exposure

Anderson, R. M., Johnson, S. B., Lingg, R. T., Hinz, D. C., Romig‐Martin, S. A., & Radley, J. J. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz092 · Cited by 38

Chinese Herbal Medicine for the Treatment of Depression: Effects on the Neuroendocrine-Immune Network

Li, C., Huang, B., & Zhang, Y. (2021) · Pharmaceuticals · doi:10.3390/ph14010065 · Cited by 34

Expression of Cntn1 is regulated by stress and associated with anxiety and depression phenotypes

Li, S.-J., Cao, W., Zhou, S.-F., Ma, M., Zhang, W., Fang, L., & Li, C.-Q. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.03.012 · Cited by 32

Leucine–Histidine Dipeptide Attenuates Microglial Activation and Emotional Disturbances Induced by Brain Inflammation and Repeated Social Defeat Stress

Ano, Y., Kita, M., Kitaoka, S., & Furuyashiki, T. (2019) · Nutrients · doi:10.3390/nu11092161 · Cited by 33

Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience in Rats

Tan, Z.-N., Li, Y., Guan, Y., Iqbal, J., Wang, C., Yan, R., & Ma, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021206 · Cited by 32

Loss of Microglia and Impaired Brain-Neurotrophic Factor Signaling Pathway in a Comorbid Model of Chronic Pain and Depression

Zhu, C., Xu, J., Lin, Y., Ju, P., Duan, D., Luo, Y., Ding, W., Huang, S., Chen, J., & Cui, D. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00442 · Cited by 31

Control of complex behavior by astrocytes and microglia

Ortinski, P. I., Reissner, K. J., Turner, J. R., Anderson, T. L., & Scimemi, A. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104651 · Cited by 32

Microglia-specific transcriptional repression of interferon-regulated genes after prolonged stress in mice

Zhang, Y., Dong, Y., Zhu, Y., Sun, D., Wang, S., Weng, J., Zhu, Y., Peng, W., Yu, B., & Jiang, Y. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100495 · Cited by 29

Excitatory Neuron-Derived Interleukin-34 Controls Cortical Developmental Microglia Function

Devlin, B. A., Nguyen, D. M., Ribeiro, D., Grullon, G., Clark, M. J., Finn, A., Ceasrine, A. M., Oxendine, S. R., Deja, M., Shah, A., et al. (2024) · Immunity · doi:10.1016/j.immuni.2025.06.002 · Cited by 37

Microglia: sculptors of neuropathic pain?

Ward, H. L., & West, S. J. (2020) · Royal Society Open Science · doi:10.1098/rsos.200260 · Cited by 35

Benefits of animal models to understand the pathophysiology of depressive disorders

Czéh, B., & Simon, M. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110049 · Cited by 30

Helicid Ameliorates Learning and Cognitive Ability and Activities cAMP/PKA/CREB Signaling in Chronic Unpredictable Mild Stress Rats

Li, X., Qi, W.-W., Zhang, Y., Si-yan, J., Yang, B., Xiong, L., & Tong, J. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00012 · Cited by 28

Neuroimmune Mechanisms and Sex/Gender-Dependent Effects in the Pathophysiology of Mental Disorders

Kokkosis, A. G., & Tsirka, S. E. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.266163 · Cited by 29

Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress

Woodburn, S. C., Asrat, H. S., Flurer, J. K., Schwierling, H. C., Bollinger, J. L., Vollmer, L. L., & Wohleb, E. S. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.01.014 · Cited by 29

Distinguishing features of depression in dementia from primary psychiatric disease

Fisher, D. W., Dunn, J. T., & Dong, H. (2024) · Discover Mental Health · doi:10.1007/s44192-023-00057-y · Cited by 34

Antidepressive properties of macrophage-colony stimulating factor in a mouse model of depression induced by chronic unpredictable stress

Ye, T., Wang, D., Cai, Z., Tong, L., Chen, Z., Lu, J., Lu, X., Huang, C., & Yuan, X. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108132 · Cited by 28

The Duration of Stress Determines Sex Specificities in the Vulnerability to Depression and in the Morphologic Remodeling of Neurons and Microglia

Gaspar, R., Soares‐Cunha, C., Domingues, A. V., Coimbra, B., Baptista, F. I., Pinto, L., Ambrósio, A. F., Rodrigues, A. J., & Gomes, C. A. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.834821 · Cited by 31

Sex as a biological variable in stress and mood disorder research

Hodes, G. E., & Kropp, D. R. (2023) · Nature Mental Health · doi:10.1038/s44220-023-00083-3 · Cited by 30

The role of the Toll like receptor 4 signaling in sex-specific persistency of depression-like behavior in response to chronic stress

Yang, E.-J., Frolinger, T., Iqbal, U. H., Estill, M. S., Shen, L., Trageser, K. J., & Pasinetti, G. M. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.10.006 · Cited by 26

Interplay between microglia and environmental risk factors in Alzheimer's disease

Zhang, M., Liang, C., Chen, X., Cai, Y., & Cui, L. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.389745 · Cited by 30

Immune System Alterations and Postpartum Mental Illness: Evidence From Basic and Clinical Research

Dye, C. N., Lenz, K. M., & Leuner, B. (2022) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2021.758748 · Cited by 30

Inflammation and Depression: A Nervous Plea for Psychiatry to Not Become Immune to Interpretation

Konsman, J. P. (2019) · Pharmaceuticals · doi:10.3390/ph12010029 · Cited by 27

Engagement of N6-methyladenisine methylation of Gng4 mRNA in astrocyte dysfunction regulated by CircHECW2

Bai, Y., Chang, D., Ren, H., Ju, M., Wang, Y., Chen, B., Li, H., Liu, X., Li, D., Huo, X., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.01.011 · Cited by 27

Astrocyte-derived CCL5-mediated CCR5 + neutrophil infiltration drives depression pathogenesis

Yao, H. P., Jiang, S., Jiao, Y., Zhou, Z.-Y., Zhu, Z., Wang, C., Zhang, K., Ma, T. F., Hu, G., Du, R., et al. (2025) · Science Advances · doi:10.1126/sciadv.adt6632 · Cited by 28

A multispecies probiotic accelerates fear extinction and inhibits relapse in mice: Role of microglia

Cui, X., Zhou, S., Xia, G., Chen, J., Jiang, L., Huang, J., & Tong, J. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108613 · Cited by 25

Pathogenic neuropsychiatric effect of stress-induced microglial interleukin 12/23 axis in systemic lupus erythematosus

Abe, N., Tarumi, M., Fujieda, Y., Takahashi, N., Karino, K., Uchida, M., Kono, M., Tanaka, Y., Hasebe, R., Kato, M., et al. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2022-222566 · Cited by 27

A Fatal Alliance between Microglia, Inflammasomes, and Central Pain

Hoffmann, S., & Beyer, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113764 · Cited by 26

Essential roles of neuropeptide VGF regulated TrkB/mTOR/BICC1 signaling and phosphorylation of AMPA receptor subunit GluA1 in the rapid antidepressant-like actions of ketamine in mice

Shen, M., Lv, D., Liu, X., Li, S., Chen, Y., Zhang, Y., Wang, Z., & Wang, C. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.10.004 · Cited by 25

ApoE4 increases susceptibility to stress-induced age-dependent depression-like behavior and cognitive impairment

Zhang, J., Lin, L., Dai, X., Xiao, N., Ye, Q., & Chen, X. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.09.029 · Cited by 26

Microglial activation in the lateral amygdala promotes anxiety‐like behaviors in mice with chronic moderate noise exposure

Peng, X., Mao, Y., Liu, Y., Dai, Q., Tai, Y., Luo, B., Liang, Y., Guan, R., Zhou, W., Chen, L., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14674 · Cited by 24

Long term effects of peripubertal stress on excitatory and inhibitory circuits in the prefrontal cortex of male and female mice

Bueno-Fernández, C., Pérez-Rando, M., Alcaide, J., Coviello, S., Sandi, C., Castillo-Gómez, E., & Nácher, J. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100322 · Cited by 23

Sex-dependent effects of microglial reduction on impaired fear extinction induced by single prolonged stress

Torres-Rodríguez, O. I., Ortiz-Nazario, E., Rivera-Escobales, Y., Velázquez, B., Alonso-Colón, M., & Porter, J. T. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.1014767 · Cited by 24

High-Fat Diet Consumption Induces Neurobehavioral Abnormalities and Neuronal Morphological Alterations Accompanied by Excessive Microglial Activation in the Medial Prefrontal Cortex in Adolescent Mice

Wang, C., Li, H., Chen, C., Yao, X., Yang, C., Yu, Z., Ren, J., Ming, Y., Huang, Y., Rong, Y., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119394 · Cited by 23

Uncovering microglial pathways driving sex-specific neurobiological effects in stress and depression

Bollinger, J. L. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100320 · Cited by 23

Microglia as a Hub for Suicide Neuropathology: Future Investigation and Prevention Targets

de Andrade, E. G., Ibáñez, F. G., & Tremblay, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.839396 · Cited by 22

Stressed Microglia: Neuroendocrine–Neuroimmune Interactions in the Stress Response

Sequeira, M. K., & Bolton, J. L. (2023) · Endocrinology · doi:10.1210/endocr/bqad088 · Cited by 26

The Importance of Inter-Species Variation in Traumatic Brain Injury-Induced Alterations of Microglial-Axonal Interactions

Gorse, K. M., & Lafrenaye, A. D. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00778 · Cited by 22

Pre-adolescent stress disrupts adult, but not adolescent, safety learning

Meyer, H. C., Gerhard, D. M., Amelio, P., & Lee, F. S. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113005 · Cited by 23

Rubrofusarin Attenuates Chronic Restraint Stress-Induced Depressive Symptoms

Yi, J. H., Jeon, J., Kwon, H., Cho, E., Yun, J., Lee, Y. C., Ryu, J. H., Park, S. J., Cho, J. H., & Kim, D. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103454 · Cited by 18

Neuroimmune Advance in Depressive Disorder

Zhao, G., & Liu, X. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-32-9271-0_4 · Cited by 20

Psilocybin’s Potential Mechanisms in the Treatment of Depression: A Systematic Review

Lee, H. J., Tsang, V. W. L., Chai, B. S., Lin, M. C., Howard, A. K., Uy, C. E., & Elefante, J. (2023) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2023.2223195 · Cited by 21

Role of age and neuroinflammation in the mechanism of cognitive deficits in sickle cell disease

Hardy, R. A., Rached, N. A., Jones, J. A., Archer, D. R., & Hyacinth, H. I. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220958011 · Cited by 23

Optogenetic Control of Spine-Head JNK Reveals a Role in Dendritic Spine Regression

Hollós, P., John, J., Lehtonen, J. V., & Coffey, E. T. (2020) · eNeuro · doi:10.1523/eneuro.0303-19.2019 · Cited by 18

Acute stress increases monocyte levels and modulates receptor expression in healthy females

van de Wouw, M., Sichetti, M., Long-Smith, C. M., Ritz, N. L., Moloney, G. M., Cusack, A.-M., Berding, K., Dinan, T. G., & Cryan, J. F. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.03.005 · Cited by 21

Unlocking the power of Lactoferrin: Exploring its role in early life and its preventive potential for adult chronic diseases

Wang, W., An, Q., Huang, K., Dai, Y., Meng, Q., & Zhang, Y. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114143 · Cited by 19

The P2X7 receptor in mood disorders: Emerging target in immunopsychiatry, from bench to bedside

von Mücke-Heim, I.-A., & Deussing, J. M. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109366 · Cited by 19

Microglial morphological/inflammatory phenotypes and endocannabinoid signaling in a preclinical model of periodontitis and depression

Robledo‐Montaña, J., Díaz-García, C., Martínez, M., Ambrosio, N., Montero, E., Marín, M. J., Virto, L., Muñoz‐López, M., Herrera, D., Sanz, M., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03213-5 · Cited by 19

The role of microglia in chronic pain and depression: innocent bystander or culprit?

Yin, N., Yan, E., Duan, W., Mao, C., Qin, F., Yang, C., Hu, Y., & Xu, X. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05780-4 · Cited by 18

Stress-induced dysfunction of neurovascular astrocytes in the prefrontal cortex contributes to sex-dependent deficits in cognition and behavior

Bollinger, J. L., Johnsamuel, S., Vollmer, L. L., Kuhn, A. M., & Wohleb, E. S. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02993-3 · Cited by 28

Maladaptive Neuroplasticity Under Stress: Insights into Neuronal and Synaptic Changes in the Prefrontal Cortex

Ren, B., Yuan, Q., Cha, S., Liu, S.-Y. M., Zhang, J., & Guo, G. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05152-5 · Cited by 21

Lumateperone Normalizes Pathological Levels of Acute Inflammation through Important Pathways Known to Be Involved in Mood Regulation

Dutheil, S., Watson, L. S., Davis, R. E., & Snyder, G. L. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0984-22.2022 · Cited by 19

Microglia and Reactive Oxygen Species Are Required for Behavioral Susceptibility to Chronic Social Defeat Stress

Guevara, C. A., Valle, P. D., & Mercedes, C. R. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2175-19.2019 · Cited by 17

A prophylactic effect of macrophage-colony stimulating factor on chronic stress-induced depression-like behaviors in mice

Jian-lin, J., Xiang, H., Lu, X., Tan, P., Yang, R., Ye, T., Chen, Z., Chen, D., He, H., Chen, J., et al. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108621 · Cited by 15

Glucocorticosteroids Effects on Brain Development in the Preterm Infant: A Role for Microglia?

Zinni, M., Pansiot, J., Billion, E., Baud, O., & Mairesse, J. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210517112913 · Cited by 15

Acute and late administration of colony stimulating factor 1 attenuates chronic cognitive impairment following mild traumatic brain injury in mice

Li, L., Yerra, L. P., Chang, B., Mathur, V., Nguyen, A., & Luo, J. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.01.022 · Cited by 16

The involvement of ADAR1 in antidepressant action by regulating BDNF via miR-432

Zhang, X., Xue, Y., Li, J., Xu, H., Yan, W., Zhao, Z., Yu, W., Zhai, X., Sun, Y., Wu, Y. J., et al. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113087 · Cited by 15

Mechanistic Studies of Gypenosides in Microglial State Transition and its Implications in Depression-Like Behaviors: Role of TLR4/MyD88/NF-κB Signaling

Cao, L., Zhao, Y., Bai, M., Geliebter, D., Geliebter, J., Tiwari, R. K., He, H.-J., Wang, Z., Jia, X.-Y., Li, J., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.838261 · Cited by 16

CSF1R regulates schizophrenia-related stress response and vascular association of microglia/macrophages

Yan, L., Li, Y., Fan, F., Gou, M., Xuan, F.-L., Feng, W., Chithanathan, K., Li, W., Huang, J., Li, H., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-02959-8 · Cited by 16

Inflammation associated with chronic heart failure leads to enhanced susceptibility to depression

Su, J., Wang, J., Ma, Y., Li, Q., Yang, Y., Huang, L., Wang, H., Li, H., Wang, Z., Tong, J., et al. (2019) · FEBS Journal · doi:10.1111/febs.14839 · Cited by 14

Microglia modulate sleep/wakefulness under baseline conditions and under acute social defeat stress in adult mice

Miyanishi, K., Hotta-Hirashima, N., Miyoshi, C., Hayakawa, S., Kakizaki, M., Kanno, S., Ikkyu, A., Funato, H., & Yanagisawa, M. (2023) · Neuroscience Research · doi:10.1016/j.neures.2023.11.010 · Cited by 13

Glial Control of Cortical Neuronal Circuit Maturation and Plasticity

Faust, T. E., Devlin, B. A., Farhy-Tselnicker, I., Ferro, A., Postolache, M., & Xin, W. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1208-24.2024 · Cited by 13

FBXO10 prevents chronic unpredictable stress‐induced behavioral despair and cognitive impairment through promoting RAGE degradation

Li, J., Zeng, Q.-C., Su, W., Song, M., Xie, M., & Mao, L. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13727 · Cited by 12

Basolateral Amygdala Reactive Microglia May Contribute to Synaptic Impairment and Depressive-Like Behavior in Mice with Bone Cancer Pain

Jiang, L., Hao, J., Yang, X., Zhu, J., Wang, Y., Huang, Y., Sun, Y., Mao, Y., Ni, K., Gu, X., et al. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03731-9 · Cited by 13

Early life selective knockdown of the TrkB receptor and maternal separation modulates adult stress phenotype

Prowse, N. A., Dwyer, Z., Thompson, A., Fortin, T., Elson, K. I., Robeson, H., Fenner, B. M., & Hayley, S. P. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112260 · Cited by 13

Corticostriatal contributions to dysregulated motivated behaviors in stress, depression, and substance use disorders

Siemsen, B. M., Franco, D., & Lobo, M. K. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.12.014 · Cited by 12

Sex-specific effects of voluntary wheel running on behavior and the gut microbiota-immune-brain axis in mice

Williams, Z. A. P., Szyszkowicz, J. K., Osborne, N., Allehyany, B., Nadon, C., Udechukwu, M. C., Santos, A. C. C., & Audet, M. (2023) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2023.100628 · Cited by 11

Comparative Proteomic Characterization of Ventral Hippocampus in Susceptible and Resilient Rats Subjected to Chronic Unpredictable Stress

Zhang, Y., Zhang, X., Liu, N., Ren, S., Xia, C., Yang, X., Lou, Y., Wang, H., Zhang, N., Xu, Y., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.675430 · Cited by 11

Telomeres: the role of shortening and senescence in major depressive disorder and its therapeutic implications

Schröder, J. D., de Araújo, J. B., de Oliveira, T., de Moura, A. B., Fries, G. R., Quevedo, J., Réus, G. Z., & Ignácio, Z. M. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2021-0070 · Cited by 12

Prolonged Early Exposure to a High-Fat Diet Augments the Adverse Effects on Neurobehavior and Hippocampal Neuroplasticity

Yao, X., Zhao, J., Yuan, Y., Wang, C., Yu, Z., Huang, Z., Chen, C., Yang, C., Ren, J., Ma, Y., et al. (2023) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.06.005 · Cited by 10

Anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa) via regulating the synaptic plasticity in hippocampus

Wei, Q.-Q., Yin, Y., Qiao, Y.-X., Ni, H., Han, S.-Y., Yao, Y., Li, Y., Zhang, L., & Li, J. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176394 · Cited by 10

Permethrin exposure primes neuroinflammatory stress response to drive depression-like behavior through microglial activation in a mouse model of Gulf War Illness

Naughton, S. X., Yang, E.-J., Iqbal, U. H., Trageser, K. J., Charytonowicz, D., Masieri, S., Estill, M. S., Wu, H. D., Raval, U., Lyu, W., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03215-3 · Cited by 10

Glucocorticoid regulation of diurnal spine plasticity in the murine ventromedial prefrontal cortex

Miller, A. M., Daniels, R. M., Sheng, J. A., Wu, T. J., & Handa, R. J. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13212 · Cited by 8

Brief Maternal Separation Promotes Resilience to Anxiety-like and Depressive-like Behaviors in Female C57BL/6J Offspring with Imiquimod-Induced Psoriasis

Zhou, L., Wu, Z., Li, Y., Xiao, L., Wang, H., & Wang, G. (2022) · Brain Sciences · doi:10.3390/brainsci12091250 · Cited by 11

Chronic Stress Exacerbates Hyperglycemia-Induced Affective Symptoms in Male Mice

McCready, R. G., Gilley, K., Kusumo, L. E., Hall, G. M., & Vichaya, E. G. (2023) · NeuroImmunoModulation · doi:10.1159/000534669 · Cited by 9

Inhibition of prefrontal cortex parvalbumin interneurons mitigates behavioral and physiological sequelae of chronic stress in male mice

Nawreen, N., Oshima, K. M., Chambers, J. B., Smail, M. A., & Herman, J. P. (2024) · Stress · doi:10.1080/10253890.2024.2361238 · Cited by 10

Ultrastructural features of psychological stress resilience in the brain: a microglial perspective

Ibáñez, F. G., VanderZwaag, J., Deslauriers, J., & Tremblay, M. (2024) · Open Biology · doi:10.1098/rsob.240079 · Cited by 11

Astrocytic FABP7 Alleviates Depression‐Like Behaviors of Chronic Unpredictable Mild Stress Mice by Regulating Neuroinflammation and Hippocampal Spinogenesis

Geng, Z., Peng, F., Cheng, Z., Su, J., Song, J., Han, X., Li, R., Li, X., Cui, R., & Li, B. (2025) · The FASEB Journal · doi:10.1096/fj.202403417rr · Cited by 14

Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors

Gao, S., Chen, J.-Q., Zhou, H.-Y., Luo, L., Zhang, B.-Y., Li, M., He, H., Chen, C., & Guo, Y. (2023) · iScience · doi:10.1016/j.isci.2023.106488 · Cited by 10

Microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through ERK1/2-mediated BDNF synthesis in the hippocampus

Ni, M., Zheng, M., Chen, B., Lu, X., Zhao, H., Zhu, T., Cheng, L., Han, H., Ye, T., Liu, H., et al. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109693 · Cited by 9

Supporting microglial niches for therapeutic benefit in psychiatric disorders

Churchward, M. A., Michaud, E., & Todd, K. G. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109648 · Cited by 9

Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress

Ano, Y., Kitaoka, S., Ohya, R., Kondô, K., & Furuyashiki, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249612 · Cited by 9

Targeting ApoE–KCC2 Signaling Rescues GABAergic Synaptic Dysfunction and Depression-like Behaviors in Mice

Xu, C., Liu, J., Guo, M., Wang, J., Bai, X., Zhang, C., Luan, X., Pei, H., Liu, H., Lv, X., et al. (2025) · Research · doi:10.34133/research.0746 · Cited by 8

Caesarean section and offspring’s emotional development: Sex differences and the role of key neurotransmitters

Xie, J., Qin, X., Shu, L., Li, P., Liu, Z., Zhu, P., Tao, F., & Huang, K. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147562 · Cited by 8

Anxiety and ultrastructural consequences of chronic mild stress in rats

Zhvania, M. G., Japaridze, N. J., Tizabi, Y., Sharikadze, I., Pochkhidze, N., & Cheishvili, L. A. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136390 · Cited by 8

Excitatory Neuron-Derived Interleukin-34 Controls Cortical Developmental Microglia FunctionPreprint

Devlin, B. A., Nguyen, D. M., Ribeiro, D., Grullon, G., Clark, M. J., Finn, A., Ceasrine, A. M., Oxendine, S. R., Deja, M., Shah, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.10.589920 · Cited by 8

Microglia Morphology in the Developing Primate Amygdala and Effects of Early Life Stress

King, D. P., Abdalaziz, M., Majewska, A. K., Cameron, J. L., & Fudge, J. L. (2025) · eNeuro · doi:10.1523/eneuro.0466-24.2024 · Cited by 7

Cognitive impairment following maternal separation in rats mediated by the NAD+/SIRT3 axis via modulation of hippocampal synaptic plasticity

Hao, K., Chen, F., Xu, S., Xiong, Y., Xu, R., Huang, H., Shu, C., Lv, Y., Wang, G., & Wang, H. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03318-2 · Cited by 8

Alleviation of Depression-Like Symptoms Through Orientin-Mediated Regulation of Neuroinflammation and PI3K/AKT Signaling

Du, Y., Yang, J., Li, F. R., Wang, L., Tian, Y., Yang, L., & Luo, L. (2025) · ACS Omega · doi:10.1021/acsomega.5c02585 · Cited by 7

Gut microbiota dysbiosis and metabolic perturbations of bile/glyceric acids in major depressive disorder with IBS comorbidity

Du, J.-Y., Zhang, Z.-J., Tan, L., Yang, H. J., Yang, R., Chen, Y., Tan, G., Li, J., Li, W., Yang, L., et al. (2025) · mBio · doi:10.1128/mbio.02447-25 · Cited by 7

Unique Sensory and Motor Behavior in Thy1-GFP-M Mice before and after Spinal Cord Injury

Faw, T. D., Lerch, J. K., Thaxton, T. T., Deibert, R. J., Fisher, L. C., & Basso, D. M. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5395 · Cited by 7

Investigation of microglial diversity in a LRRK2 G2019S mouse model of Parkinson's disease

Iovino, L., VanderZwaag, J., Kaur, G., Khakpour, M., Giusti, V., Donadon, M., Chiavegato, A., Lopes, L. T., Greggio, E., Tremblay, M., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106481 · Cited by 7

Exercise alleviates CUS-induced depressive-like behaviors by modulating paracellular and transcellular permeability of the blood-brain barrier in the prefrontal cortex

Luo, Y., Meng, D., Tang, H., Wu, P., & Zhang, Y. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115286 · Cited by 7

From Stress to Substance Use Disorders: The Expanding Role of Microglia–Astrocyte Crosstalk in Neuroimmune and Glutamate Alterations in the Nucleus Accumbens

Cancela, L. M., Mongi‐Bragato, B., Avalos, M. P., & Bollati, F. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010385 · Cited by 9

Granulocyte-macrophage colony-stimulating factor-triggered innate immune tolerance against chronic stress-induced behavioral abnormalities in mice

Chen, Z., Liu, H., Ye, Y., Chen, D., Lu, Q., Lu, X., & Huang, C. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108924 · Cited by 6

Functional and morphological adaptation of medial prefrontal corticotropin releasing factor receptor 1-expressing neurons in male mice following chronic ethanol exposure

Patel, R. R., Gandhi, P. J., Spencer, K. S. R., Salem, N. A., Erikson, C. M., Borgonetti, V., Vlkolinský, R., Rodriguez, L., Nadav, T., Bajo, M., et al. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100657 · Cited by 6

Adolescent high fat diet alters the transcriptional response of microglia in the prefrontal cortex in response to stressors in both male and female mice

Davis, A. B., Lloyd, K. R., Bollinger, J. L., Wohleb, E. S., & Reyes, T. M. (2024) · Stress · doi:10.1080/10253890.2024.2365864 · Cited by 6

The microglial innate immune receptor TREM2 participates in fear memory formation through excessive prelimbic cortical synaptic pruning

Zhang, L., Peng, C., Chu, Y.-Q., Zhou, Z.-M., Hua, R., & Zhang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1412699 · Cited by 8

511. Stress-Induced Neuronal CSF1 Provokes Microglia-Mediated Dendritic Remodeling and Depressive-Like Behavior

Wohleb, E. S., Terwilliger, R. Z., Duman, C. H., & Duman, R. S. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.1119 · Cited by 9

Abstract # 2066 Chronic stress-induced glucocorticoid signaling drives microglia-mediated neuronal remodeling and depressive-like behaviors

Horchar, M. J., & Wohleb, E. S. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.11.194

Abstract # 1772 Microglia-mediated dendritic remodeling is associated with alterations in neuron-derived signals after chronic unpredictable stress

Wohleb, E. S., & Duman, R. S. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.065

Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress

Horchar, M. J., & Wohleb, E. S. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.030 · Cited by 100

Diazepam limits microglia-mediated neuronal remodeling in the prefrontal cortex and associated behavioral consequences following chronic unpredictable stress

Bollinger, J. L., Horchar, M. J., & Wohleb, E. S. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0720-1 · Cited by 44