Methylphenidate improves deficient error evaluation in children with ADHD; an event-related brain potential study
Open accessAbstract
Children with ADHD make more errors than control children in response-conflict tasks. To explore whether this is mediated by enhanced sensitivity to conflict or reduced error-processing, task-related brain activity (N2, Ne/ERN, Pe) was compared between 8- to 12-year-old children with ADHD and healthy controls during performance of a flanker task. Furthermore, effects of methylphenidate were investigated in ADHD children in a second study. ADHD children made more errors, especially in high-response-conflict conditions, without showing post-error slowing. N2 amplitudes were enhanced on trials resulting in an error response, Ne/ERN amplitude was unaffected and Pe amplitude was reduced in the ADHD group. Methylphenidate reduced errors in both low- and high-conflict conditions and normalized Pe amplitudes in children with ADHD. It was concluded that the inaccurate behaviour of ADHD children in conflict tasks might be related to reduced error-awareness and higher sensitivity to response conflict. Methylphenidate's ameliorating effects might be established through its influence on brain networks including posterior (parietal) cortex, enabling children with ADHD to allocate more attention to significant events.
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Mph improves error processing in children with ADHD.
“a recent placebo-controlled study revealed that Mph improves error processing in children with ADHD (Jonkman et al., 2007).”
From Error and feedback processing in children with ADHD and children with Autistic Spectrum Disorder: An EEG event-related potential study (2008) · cites this paper as Jonkman et al., 2007
The Pe is fairly consistently found to be decreased in children with ADHD.
“The Pe is fairly consistently found to be decreased in children with ADHD, suggesting that they become less aware of their committed errors (Jonkman et al., 2007; Overtoom et al., 2002; Wiersema et al., 2005; but see: Burgio-Murphy et al., 2007).”
From Error and feedback processing in children with ADHD and children with Autistic Spectrum Disorder: An EEG event-related potential study (2008) · cites this paper as Jonkman et al., 2007
Mph does not modulate the ERN in children with ADHD.
“Jonkman and colleagues, however, did not find a modulating effect of Mph on the ERN in children with ADHD.”
From Error and feedback processing in children with ADHD and children with Autistic Spectrum Disorder: An EEG event-related potential study (2008) · cites this paper as Jonkman et al., 2007
Mph-treated children with ADHD showed a normalised error-related Pe amplitude.
“In this study children with ADHD treated with Mph showed a normalised error-related Pe amplitude.”
From Error and feedback processing in children with ADHD and children with Autistic Spectrum Disorder: An EEG event-related potential study (2008) · cites this paper as Jonkman et al., 2007
These data, as well as the data by Jonkman and colleagues, suggest that Mph improves conscious error processing in ADHD, but not early error detection.
“Concludingly, these data, as well as the data by Jonkman and colleagues, suggest that Mph improves conscious error processing in ADHD, but not early error detection.”
From Error and feedback processing in children with ADHD and children with Autistic Spectrum Disorder: An EEG event-related potential study (2008) · cites this paper as Jonkman et al., 2007
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References 67 · Cited by 111
- Authors
- Jonkman, L. M., van Melis, J. J. M., Kemner, C., & Markus, C. R.
- Affiliations
- Maastricht University (NL)
- University Medical Center Utrecht (NL)
- Corresponding author
- Jonkman, Lisa.M.
- ORCID
- Jonkman, Lisa.M.
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 76
- Issue
- 3
- Pages
- 217-229
- ISSN
- 0301-0511 (ISSN-L)
- OpenAlex
- W2095768191
- Cited by
- 111
- References
- 67
- Citations by year
- 2023: 2 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 3 · 2016: 10 · 2015: 4 · 2014: 5 · 2013: 9 · 2012: 6
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Keywords
- attention deficit hyperactivity disorder, methylphenidate, error processing, response conflict, flanker task, N2, error-related negativity, P3, post-error slowing, error awareness, children, event-related potentials, parietal cortex
- MeSH terms
- Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Brain, Brain Mapping, Child, Choice Behavior, Conflict, Psychological, Electroencephalography, Electrooculography, Evoked Potentials, Female, Humans, Male, Mental Processes, Methylphenidate, Neuropsychological Tests, Reaction Time
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