The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Antioxidants alleviated low-temperature stress in microalgae by modulating reactive oxygen species to improve lipid production and antioxidant defense
Abstract
The aim of this study was to investigate the effects of various concentrations of antioxidants, including butyl hydroxy anisd (BHA), butylated hydroxytoluene (BHT), fulvic acid (FA), melatonin (MT), glycine betaine (GB) and putrescine (Put), on growth and lipid synthesis of microalgae under low-temperature (15 ℃). Changes in biochemical indicators, reactive oxygen species (ROS) level, glutathione (GSH) content and antioxidant enzyme activities were also studied. The results indicated that the maximum biomass concentration (1.3 g/L) and lipid productivity (75.3 ± 5.8 mg/L d-1) were achieved under 100 μM MT and 1 μM GB, respectively. Moreover, antioxidants were able to increase the GSH and antioxidant enzymes activities in algal cells under low-temperature stress. This study was enlightening for the utilization of antioxidants to improve the resistance to low-temperature stress and lipid production in microalgae, and provided a theoretical basis for the application of microalgae for lipid accumulation in cold regions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Excess oxygen can lead to photooxidation of chlorophyll, which has a negative effect on the efficiency of photosynthesis, while a lack of oxygen can limit the metabolic processes of microalgae.
“An excess of oxygen can lead to photooxidation of the chlorophyll, which has a negative effect on the efficiency of photosynthesis. Conversely, a lack of oxygen can limit the metabolic processes of microalgae [196].”
From Multi-Sensing Monitoring of the Microalgae Biomass Cultivation Systems for Biofuels and Added Value Products Synthesis—Challenges and Opportunities (2025) · cites this paper as [196]
Citations
Cites
Beneficial Effects of Betaine: A Comprehensive Review
Arumugam, M. K., Paal, M. C., Donohue, T. M., Ganesan, M., Osna, N. A., & Kharbanda, K. K. (2021) · Biology · doi:10.3390/biology10060456 · Cited by 313
Song, Q., Kong, F., Liu, B.-F., Song, X., & Ren, H. (2024) · Environmental Science and Ecotechnology · doi:10.1016/j.ese.2024.100420 · Cited by 142
Self-citationZhao, Y., Yue, C., Ding, W., Li, T., Xu, J., Zhao, P., Ma, H., & Yu, X. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.06.111 · Cited by 99
Li, Q., Li, L., Zhang, Y., Gao, H., Zhao, Y., & Yu, X. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.04.014 · Cited by 97
Song, X., Liu, B.-F., Kong, F., Song, Q., Ren, N., & Ren, H. (2022) · Algal Research · doi:10.1016/j.algal.2022.102925 · Cited by 87
Self-citationLauritano, C., Rizzo, C., Giudice, A. L., & Saggiomo, M. (2020) · Microorganisms · doi:10.3390/microorganisms8121957 · Cited by 84
Zhao, Y., Wang, Q., Gu, D., Huang, F., Liu, J., Yu, L., & Yu, X. (2023) · Bioresource Technology · doi:10.1016/j.biortech.2023.130093 · Cited by 78
Leong, W. H., Lim, J. W., Lam, M. K., Lam, S., Sin, J., & Samson, A. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124455 · Cited by 77
Dasan, Y. K., Lam, M. K., Yusup, S. B., Lim, J. W., Show, P. L., Tan, I. S., & Lee, K. T. (2020) · Journal of CO2 Utilization · doi:10.1016/j.jcou.2020.101226 · Cited by 75
Leong, W. H., Kiatkittipong, K., Kiatkittipong, W., Cheng, Y. W., Lam, M. K., Shamsuddin, R., Mohamad, M., & Lim, J. W. (2020) · Processes · doi:10.3390/pr8111427 · Cited by 73
Kuo, E. Y., Cai, M.-S., & Lee, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-70247-z · Cited by 72
Lin, T. W., Rao, M., Lu, H., et al. (2017) · Physiologia Plantarum · doi:10.1111/ppl.12622 · Cited by 59
Wang, J.-H., Kong, F., Liu, B.-F., et al. (2024) · Separation and Purification Technology · doi:10.1016/j.seppur.2024.128839 · Cited by 51
Self-citationEnhanced astaxanthin production from Haematococcus pluvialis using butylated hydroxyanisole
Minmin, S., Ding, W., Zhao, Y., Xu, J., Zhao, P., Li, T., Ma, H., & Yu, X. (2016) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2016.08.019 · Cited by 46
Li, X., Li, X., Han, B., Zhao, Y., Li, T., Zhao, P., & Yu, X. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.122179 · Cited by 46
Lin, S.-T., Chiou, C.-W., Chu, Y., et al. (2016) · Plant and Cell Physiology · doi:10.1093/pcp/pcw129 · Cited by 42
Yeh, H.-L., Lin, T. W., Chen, C., et al. (2019) · Plant and Cell Physiology · doi:10.1093/pcp/pcz110 · Cited by 35
Oxidation characteristics and thermal stability of Butylated hydroxytoluene
Dai, S., Yu, C., Liang, M., et al. (2023) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2023.104932 · Cited by 31
Yu, C.-L., Hu, Y., Zhang, Y., Luo, W., Zhang, J., Xu, P., Qian, J., Li, J., Yu, J., Liu, J., et al. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.141387 · Cited by 25
Chang, H.-L., Kang, C.-Y., & Lee, T. (2013) · Journal of Plant Physiology · doi:10.1016/j.jplph.2013.02.001 · Cited by 20
Chang, H.-Y., Lin, S., Ko, T., et al. (2017) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2017.09.026 · Cited by 19
Qi, F., Gao, Y., Liu, J., et al. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-27561-6 · Cited by 19
Characteristics of the Northern Hemisphere cold regions changes from 1901 to 2019
Huang, Y., Zhang, L., Li, Y., Ren, C., Pan, T., Zhang, W.-S., Zhang, F., Li, C., Gu, J., & Liu, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-30263-1 · Cited by 18
Li, T., Li, J., Sheng, X., Li, B., Wang, W., Xue, Y., Zhang, J., Li, W., Wang, X., Wang, F., et al. (2022) · Renewable Energy · doi:10.1016/j.renene.2023.02.037 · Cited by 13
Tsai, T.-Y., Chien, Y., Zheng, Y.-Y., Li, Y.-C., Chen, J., Su, R., Ben-Sheleg, A., Khozin‐Goldberg, I., Vonshak, A., & Lee, T. (2024) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2023.108326 · Cited by 11
Tsai, T., Khozin‐Goldberg, I., Vonshak, A., & Lee, T. (2024) · Physiologia Plantarum · doi:10.1111/ppl.14168 · Cited by 11
Sartaj, K., Tripathi, S., Patel, A., Poluri, K. M., & Prasad, R. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.144562 · Cited by 7
Flagged first, then by citations
Cited by
Sorted by citations
Dębowski, M., Kazimierowicz, J., & Zieliński, M. (2025) · Applied Sciences · doi:10.3390/app15137324 · Cited by 30
Metadata
- Authors
- Song, X., Kong, F., Liu, B.-F., Song, Q., Ren, N.-Q., & Ren, H.-Y.
- Affiliations
- Harbin Institute of Technology (CN)
- Northeast Agricultural University (CN)
- Corresponding author
- Ren, Hong-Yu
- Venue
- Bioresource Technology
- Publisher
- Elsevier BV
- Published
- 2024-12
- Volume
- 413
- Pages
- 131451
- ISSN
- 0960-8524 (ISSN-L)
- OpenAlex
- W4402307221
- Cited by
- 87
- References
- 27
- Citations by year
- 2026: 25 · 2025: 45 · 2024: 17
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Bioresource Technology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Key Research and Development Program of Heilongjiang
- National Natural Science Foundation of China
- Shanghai Tongji Gao Tingyao Environmental Science and Technology Development Foundation
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Physical Sciences › Environmental Science › Environmental Chemistry › Aquatic Ecosystems and Phytoplankton Dynamics
- Keywords
- antioxidants, cold stress, microalgae, lipid production, reactive oxygen species, glutathione, antioxidant enzymes, melatonin, betaine, butylated hydroxytoluene, fulvic acid, putrescine, cold tolerance, biomass accumulation
- MeSH terms
- Antioxidants, Cold Temperature, Glutathione, Lipids, Stress, Physiological, Reactive Oxygen Species, Biomass, Lipid Metabolism, Microalgae
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
