A quartz crystal microbalance sensor based on mussel-inspired molecularly imprinted polymer
Abstract
In this work, we describe a simple, inexpensive and fast method for the generation of molecularly imprinted polymer (MIP) film on quartz crystal microbalance (QCM) crystals using mussel-inspired polymer. Commonly known as a neurotransmitter, dopamine is also a small-molecule mimic of the adhesive proteins of mussels. Polymerization of dopamine in the presence of template molecule (1,3,5-pentanetricarboxylic acid, an analogue of domoic acid, in this case) could produce an adherent molecularly imprinted polydopamine film coating on QCM crystals. Advantages, such as high hydrophilicity, high biocompatibility and controllable thickness, make this molecularly imprinted polydopamine film an attractive recognition element for sensors. Selective rebinding of domoic acid on mussel-inspired molecularly imprinted polymer (m-MIP) coated crystal was observed as a frequency shift quantified by piezoelectric microgravimetry with the QCM system. The decreasing frequency shows a good linear relationship with the concentration of domoic acid. The quantitation limit of domoic acid was 5 ppb with the linear range of 0-100 ppb. The QCM sensor has high selectivity and was able to distinguish domoic acid from its analogous p-phthalic acid and o-phthalic acid owing to the molecular imprinting effect. In addition, the practical analytical performance of the sensor was examined by evaluating the detection of domoic acid in mussel extracts with satisfactory results. It is envisaged that m-MIP could be…
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Biomacromolecules such as proteins, peptides, and DNA can anchor on the surface of biosubstitutes via the polydopamine coating layer.
“In addition, biomacromolecules, such as proteins, peptides, and DNA, can anchor on the surface of biosubstitutes via the PDA coating layer [50, 57–60].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [59]
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Polydopamine-Assisted Surface Modification for Bone Biosubstitutes
Huang, S., Liang, N., Hu, Y., Zhou, X., & Abidi, N. (2016) · BioMed Research International · doi:10.1155/2016/2389895 · Cited by 97 · see citing works
- Authors
- Zhou, W.-H., Tang, S.-F., Yao, Q.-H., Chen, F.-R., Yang, H.-H., & Wang, X.-R.
- Affiliations
- Fuzhou University (CN)
- First Institute of Oceanography (CN)
- Venue
- Biosensors and Bioelectronics
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 26
- Issue
- 2
- Pages
- 585-589
- ISSN
- 0956-5663 (ISSN-L)
- OpenAlex
- W1969129717
- Cited by
- 69
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2022: 7 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 3 · 2014: 8 · 2013: 8 · 2012: 8
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biosensors and Bioelectronics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Physical Sciences › Engineering › Biomedical Engineering › Acoustic Wave Resonator Technologies
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- molecularly imprinted polymers, polydopamine, mussel-inspired materials, quartz crystal microbalance, recognition elements, mussel extracts, frequency shift
- MeSH terms
- Animals, Dopamine, Equipment Design, Humans, Polymers, Surface Properties, Biosensing Techniques, Equipment Failure Analysis, Biomimetic Materials, Bivalvia, Micro-Electrical-Mechanical Systems
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