Mouthguard biosensor with telemetry system for monitoring of saliva glucose: A novel cavitas sensor
Open accessAbstract
We develop detachable "Cavitas sensors" to apply to the human oral cavity for non-invasive monitoring of saliva glucose. A salivary biosensor incorporating Pt and Ag/AgCl electrodes on a mouthguard support with an enzyme membrane is developed and tested. Electrodes are formed on the polyethylene terephthalate glycol (PETG) surface of the mouthguard. The Pt working electrode is coated with a glucose oxidase (GOD) membrane. The biosensor seamlessly is integrated with a glucose sensor and a wireless measurement system. When investigating in-vitro performance, the biosensor exhibits a robust relationship between output current and glucose concentration. In artificial saliva composed of salts and proteins, the glucose sensor is capable of highly sensitive detection over a range of 5-1000µmol/L of glucose, which encompasses the range of glucose concentrations found in human saliva. We demonstrate the ability of the sensor and wireless communication module to monitor saliva glucose in a phantom jaw imitating the structure of the human oral cavity. Stable and long-term real-time monitoring (exceeding 5h) with the telemetry system is achieved. The mouthguard biosensor will be useful as a novel method for real-time non-invasive saliva glucose monitoring for better management of dental patients.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Oral biosensing devices have been further miniaturized to a detachable 'cavitas sensors' device to measure salivary glucose levels on a mouthguard platform fabricated to fit over the wearer's teeth.
“Oral biosensing devices have been further miniaturized to a detachable ‘cavitas sensors’ device to measure salivary glucose levels on a mouthguard platform fabricated to fit over the wearer’s teeth (Fig. 6b)148.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [148]
The developed cavitas sensors are based on a GOX-modified poly(ethylene terephthalate) glycol (PETG) surface, and the device is seamlessly integrated with a wireless transmitter on a custom-fitted monolithic mouthguard platform.
“The developed sensors are based on a GOX-modified poly(ethylene terephthalate) glycol (PETG) surface, and the device is seamlessly integrated with a wireless transmitter on a custom-fitted monolithic mouthguard platform.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [148]
This configuration enables the telemetric measurement of salivary glucose in artificial saliva over the relevant physiological range (5-1000 μM) and the device has been further characterized through connection to a phantom jaw that mimics the human oral cavity with a saliva flow system.
“This configuration enables the telemetric measurement of salivary glucose in artificial saliva over the relevant physiological range (5–1000 μM) and the device has been further characterized through connection to a phantom jaw that mimics the human oral cavity with a saliva flow system.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [148]
The citation lists haven’t been fetched yet
References 23 · Cited by 356
- Authors
- Arakawa, T., Kuroki, Y., Nitta, H., Chouhan, P., Toma, K., Sawada, S.-I., Takeuchi, S., Sekita, T., Akiyoshi, K., Minakuchi, S., & Mitsubayashi, K.
- Affiliations
- Tokyo Medical and Dental University (JP)
- Imperial College London (GB)
- Kyoto University (JP)
- Corresponding author
- Mitsubayashi, Kohji
- ORCID
- Venue
- Biosensors and Bioelectronics
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 84
- Pages
- 106-111
- ISSN
- 0956-5663 (ISSN-L)
- OpenAlex
- W2191247297
- Cited by
- 356
- References
- 23
- Citations by year
- 2026: 21 · 2025: 37 · 2024: 42 · 2023: 53 · 2022: 52 · 2021: 49 · 2020: 38 · 2019: 26 · 2018: 22 · 2017: 9 · 2016: 7
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 589 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Biosensors and Bioelectronics (acceptedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Science and Technology Agency
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- non-invasive glucose monitoring, glucose oxidase, platinum electrode, Ag/AgCl electrodes, wireless telemetry, dental patients, real-time monitoring
- MeSH terms
- Electrodes, Enzymes, Immobilized, Equipment Design, Glucose, Glucose Oxidase, Humans, Monitoring, Physiologic, Polyethylene Glycols, Polyethylene Terephthalates, Saliva, Telemetry, Biosensing Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
