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Optical biosensors based on refractometric sensing schemes: A review
Abstract
Biosensor technology is an active field of research and development presenting rapid progress in recent decades, and the subfield of optical biosensors based on refractometric sensing schemes has developed dramatically during this time. This review focuses on advances in the refractometric sensing-based guided-wave optical biosensors particularly in the last two decades. It starts with a concise discussion on the underlying principles of label-free refractometric biosensor. Subsequently, advances in biosensor design, especially the transducer configuration and the integration of the sensing device are reviewed, highlighting the challenges and efforts dedicated to improving this technology. Various surface functionalization strategies designed to produce well-defined and reproducible surface properties are introduced for evaluation. Refractometric sensing scheme-based optical biosensors have found versatile applications varying from environmental monitoring and food safety to clinical diagnostics, together with advances in these applications and others are described. This paper concludes with a brief discussion on the outlook for integrating biosensors with emerging technologies.
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Citations
Cites
Silicon photonic platforms for mid-infrared applications [Invited]
Hu, T., Dong, B., Luo, X., Liow, T.-Y., Song, J., Lee, C., & Lo, G.-Q. (2017) · Photonics Research · doi:10.1364/prj.5.000417 · Cited by 328
Cited by
Metasurface Micro/Nano-Optical Sensors: Principles and Applications
Qin, J., Jiang, S., Wang, Z., Cheng, X., Li, B., Shi, Y., Tsai, D. P., Liu, A. Q., Huang, W., & Zhu, W. (2022) · ACS Nano · doi:10.1021/acsnano.2c03310 · Cited by 359
Biofunctionalization of Multiplexed Silicon Photonic Biosensors
Puumala, L. S., Grist, S. M., Morales, J. M., Bickford, J. R., Chrostowski, L., Shekhar, S., & Cheung, K. C. (2022) · Biosensors · doi:10.3390/bios13010053 · Cited by 55
Metadata
- Authors
- Chen, Y., Liu, J., Yang, Z., Wilkinson, J. S., & Zhou, X.
- Venue
- Biosensors and Bioelectronics
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 144
- Pages
- 111693
- ISSN
- 0956-5663 (ISSN-L)
- OpenAlex
- W2972978181
- Cited by
- 219
- References
- 1
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, Y., Liu, J., Yang, Z., Wilkinson, J. S., & Zhou, X. (2019). Optical biosensors based on refractometric sensing schemes: A review. Biosensors and Bioelectronics. https://doi.org/10.1016/j.bios.2019.111693
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