The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury
Open accessAbstract
Hematopoietic stem cell transplantation (HSCT)-associated thrombotic microangiopathy (TA-TMA) is now a well-recognized and potentially severe complication of HSCT that carries a high risk of death. In those who survive, TA-TMA may be associated with long-term morbidity and chronic organ injury. Recently, there have been new insights into the incidence, pathophysiology, and management of TA-TMA. Specifically, TA-TMA can manifest as a multi-system disease occurring after various triggers of small vessel endothelial injury, leading to subsequent tissue damage in different organs. While the kidney is most commonly affected, TA-TMA involving organs such as the lung, bowel, heart, and brain is now known to have specific clinical presentations. We now review the most up-to-date research on TA-TMA, focusing on the pathogenesis of endothelial injury, the diagnosis of TA-TMA affecting the kidney and other organs, and new clinical approaches to the management of this complication after HSCT.
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Metadata
- Authors
- Jodele, S., Laskin, B. L., Dandoy, C. E., Myers, K. C., El-Bietar, J., Davies, S. M., Goebel, J., & Dixon, B. P.
- Venue
- Blood Reviews
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 29
- Issue
- 3
- Pages
- 191-204
- ISSN
- 0268-960X (ISSN-L)
- OpenAlex
- W2117803220
- Cited by
- 353
- References
- 75
- FWCI
- 8.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Jodele, S., Laskin, B. L., Dandoy, C. E., Myers, K. C., El-Bietar, J., Davies, S. M., Goebel, J., & Dixon, B. P. (2015). A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury. Blood Reviews. https://doi.org/10.1016/j.blre.2014.11.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
