The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Molecular pathogenesis of pulmonary arterial hypertension
Open accessAbstract
Recent clinical and experimental studies are redefining the cellular and molecular bases of pulmonary arterial hypertension (PAH).The genetic abnormalities first identified in association with the idiopathic form of PAH -together with a vast increase in our understanding of cell signaling, cell transformation, and cell-cell interactions; gene expression; microRNA processing; and mitochondrial and ion channel function -have helped explain the abnormal response of vascular cells to injury.Experimental and clinical studies now converge on the intersection and interactions between a genetic predisposition involving the BMPR2 signaling pathway and an impaired metabolic and chronic inflammatory state in the vessel wall.These deranged processes culminate in an exuberant proliferative response that occludes the pulmonary arterial (PA) lumen and obliterates the most distal intraacinar vessels.Here, we describe emerging therapies based on preclinical studies that address these converging pathways.
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Cites
Inflammasomes in health and disease
Strowig, T., Henao-Mejia, J., Elinav, E., & Flavell, R. (2012) · Nature · doi:10.1038/nature10759 · Cited by 2,230
Xu, W., Kaneko, F. T., Zheng, S., Comhair, S. A. A., Janocha, A. J., Goggans, T., Thunnissen, F. B. J. M., Farver, C., Hazen, S. L., Jennings, C., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2317fje · Cited by 369
Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension.
Lee, S.-J., Smith, A., Guo, L., Alastalo, T.-P., Li, M., Sawada, H., Liu, X., Chen, Z.-H., Ifedigbo, E., Jin, Y., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201005-0746oc · Cited by 217
Self-citationCovalent Peroxisome Proliferator-activated Receptor γ Adduction by Nitro-fatty Acids
Schopfer, F. J., Cole, M. P., Groeger, A. L., Chen, C.-S., Khoo, N. K. H., Woodcock, S. R., Golin-Bisello, F., Motanya, U. N., Li, Y., Zhang, J., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.091512 · Cited by 171
Cited by
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics
Luo, Z., Tian, M., Yang, G., Tan, Q., Chen, Y., Li, G., Zhang, Q., Li, Y., Wan, P., & Wu, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01080-1 · Cited by 499
Hypoxia signaling in human diseases and therapeutic targets
Lee, J. W., Ko, J., Ju, C., & Eltzschig, H. K. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0235-1 · Cited by 384
Jodele, S., Laskin, B. L., Dandoy, C. E., Myers, K. C., El-Bietar, J., Davies, S. M., Goebel, J., & Dixon, B. P. (2015) · Blood Reviews · doi:10.1016/j.blre.2014.11.001 · Cited by 353
Endothelial cells in the pathogenesis of pulmonary arterial hypertension
Evans, C. E., Cober, N. D., Dai, Z., Stewart, D. J., & Zhao, Y.-Y. (2021) · European Respiratory Journal · doi:10.1183/13993003.03957-2020 · Cited by 325
The Metabolic Theory of Pulmonary Arterial Hypertension
Paulin, R., & Michelakis, E. D. (2014) · Circulation Research · doi:10.1161/circresaha.115.301130 · Cited by 314
Metadata
- Authors
- Rabinovitch, M.
- Venue
- Journal of Clinical Investigation
- Published
- 2012-12-03
- Volume
- 122
- Issue
- 12
- Pages
- 4306-4313
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W4293257851
- Cited by
- 653
- References
- 4
- FWCI
- 32.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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