The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Antifungal properties of new series of quinoline derivatives
Open accessAbstract
The series of quinoline derivatives were prepared. The synthetic approach, analytical, and spectroscopic data of all synthesized compounds are presented. All the prepared derivatives were analyzed using the reversed-phase high performance liquid chromatography (RP-HPLC) method for the lipophilicity measurement. In the present study, the correlation between RP-HPLC retention parameter log K (the logarithm of capacity factor K) and various calculated log P data is shown. The relationships between the lipophilicity and the chemical structure of the studied compounds are discussed as well. The prepared compounds were tested for their in vitro antifungal activity. 2-[(3-Hydroxyphenylimino)methyl]quinolin-8-ol (8), 2-[(4-hydroxyphenylimino)methyl]quinolin-8-ol (9) and 2-[(2,5-dichloro-4-nitrophenylamino)methoxymethyl]quinolin-8-ol (10) showed in vitro antifungal activity comparable to or higher than that of the standard fluconazole. Structure-activity relationships among the chemical structure, the physical properties, and the biological activities of the evaluated compounds are discussed in the article.
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Cites
Physicochemical Profiling (Solubility, Permeability and Charge State)
Avdeef, A. (2001) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026013395100 · Cited by 587
Lipophilicity in Drug Action and Toxicology
(1996) · Methods and Principles in Medicinal Chemistry · doi:10.1002/9783527614998 · Cited by 409
Rees, J. R., Pinner, R. W., Hajjeh, R. A., Brandt, M. E., & Reingold, A. L. (1998) · Clinical Infectious Diseases · doi:10.1093/clinids/27.5.1138 · Cited by 397
Valkó, K. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2003.10.084 · Cited by 365
Emerging novel antifungal agents
Fostel, J. M., & Lartey, P. A. (2000) · Drug Discovery Today · doi:10.1016/s1359-6446(99)01430-0 · Cited by 123
M., L. Y. V., Castelli, M. V., Kouznetsov, V. V., Urbina, J. M., López, S. N., Sortino, M. A., Enriz, R. D., Ribas, J. C., & Zacchino, S. A. (2003) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(02)00605-3 · Cited by 122
The past, present and future of antimycotic combination therapy
Polak, A. (1999) · Mycoses · doi:10.1046/j.1439-0507.1999.00475.x · Cited by 114
Antifungal effects of fluconazole (UK 49858), a new triazole antifungal, in vitro
Odds, F. C., Cheesman, S. L., & Abbott, A. B. (1986) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/18.4.473 · Cited by 89
Hoban, D. J., Zhanel, G. G., & Karlowsky, J. A. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.6.1463 · Cited by 66
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Cited by
The biology and chemistry of antifungal agents: A review
Kathiravan, M. K., Salake, A. B., Chothe, A. S., Dudhe, P. B., Watode, R. P., Mukta, M. S., & Gadhwe, S. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.04.045 · Cited by 664
Metadata
- Authors
- Musiol, R., Jampilek, J., Buchta, V., Silva, L., Niedbala, H., Podeszwa, B., Palka, A., Majerz-Maniecka, K., Oleksyn, B., & Polanski, J.
- Venue
- Bioorganic & Medicinal Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 14
- Issue
- 10
- Pages
- 3592-3598
- ISSN
- 0968-0896 (ISSN-L)
- OpenAlex
- W2092444417
- Cited by
- 286
- References
- 10
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Musiol, R., Jampilek, J., Buchta, V., Silva, L., Niedbala, H., Podeszwa, B., Palka, A., Majerz-Maniecka, K., Oleksyn, B., & Polanski, J. (2006). Antifungal properties of new series of quinoline derivatives. Bioorganic & Medicinal Chemistry. https://doi.org/10.1016/j.bmc.2006.01.016
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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