Synthesis of 2′-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells
Abstract
A novel glucose-conjugated paclitaxel 5 was synthesized using succinic acid as linker between 2'-paclitaxel and methyl 2'-glucopyranose. 5 has not only improved the pharmaceutical properties of paclitaxel, such as solubility and stability, but also enhanced the specific target delivery to MCF-7 cells without the cytotoxicity against normal cells. Therefore, the glucose conjugation may be potentially used in the targeted delivery of other drugs into cells via glucose transporters (GLUTs) for cancer therapy.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Glucose conjugates of several cancer chemotherapeutics, including paclitaxel and doxorubicin, experienced a higher therapeutic efficacy in vivo.
“Glucose conjugates of several cancer chemotherapeutics, including paclitaxel and doxorubicin [159,160,161], experienced a higher therapeutic efficacy in vivo.”
From Iron as a central player and promising target in cancer progression (2019) · cites this paper as [160]
Cites
Rowinsky, E. K., & Donehower, R. C. (1995) · New England Journal of Medicine · doi:10.1056/nejm199504133321507 · Cited by 1,924 · see citing works
Gelderblom, H. A. J., Verweij, J., Nooter, K., & Sparreboom, A. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(01)00171-x · Cited by 1,659 · see citing works
Taxol: A Novel Investigational Antimicrotubule Agent
Rowinsky, E. K., Cazenave, L. A., & Donehower, R. C. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.15.1247 · Cited by 1,096 · see citing works
Raval, R. R., Lau, K. W., Tran, M. G. B., Sowter, H. M., Mandriota, S. J., Li, J.-L., Pugh, C. W., Maxwell, P. H., Harris, A. L., & Ratcliffe, P. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5675-5686.2005 · Cited by 940 · see citing works
Kanai, Y., Lee, W. S., You, G., Brown, D., & Hediger, M. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci116972 · Cited by 628 · see citing works
Eisenhauer, E. A., Huinink, W. W. T. B., Swenerton, K. D., Gianni, L., Myles, J., van der Burg, M. E. L., Kerr, I. G., Vermorken, J. B., Buser, K., & Colombo, N. (1994) · Journal of Clinical Oncology · doi:10.1200/jco.1994.12.12.2654 · Cited by 625 · see citing works
Kayano, T., Burant, C., Fukumoto, H., Gould, G. W., Fan, Y. S., Eddy, R. L., Byers, M. G., Shows, T. B., Seino, S., & Bell, G. I. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38295-x · Cited by 389 · see citing works
The Glucose Transporter of Mammalian Cells
Wheeler, T. J., & Hinkle, P. C. (1985) · Annual Review of Physiology · doi:10.1146/annurev.ph.47.030185.002443 · Cited by 228 · see citing works
Identification of a novel glucose transporter-like protein—GLUT-12
Rogers, S., Macheda, M. L., Docherty, S. E., Carty, M. D., Henderson, M. A., Soeller, W. C., Gibbs, E. M., James, D. E., & Best, J. D. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.3.e733 · Cited by 220 · see citing works
Schmitt‐Sody, M., Strieth, S., Krasnici, S., Sauer, B., Schulze, B. G., Teifel, M., Michaelis, U., Naujoks, K., & Dellian, M. (2003) · PubMed · Cited by 192 · see citing works
Hydrotropic Solubilization of Paclitaxel: Analysis of Chemical Structures for Hydrotropic Property
Lee, J., Lee, S. C., Acharya, G. S., Chang, C., & Park, K. (2003) · Pharmaceutical Research · doi:10.1023/a:1024458206032 · Cited by 190 · see citing works
Gleadle, J., & Ratcliffe, P. J. (1997) · Blood · doi:10.1182/blood.v89.2.503 · Cited by 182 · see citing works
Positron-emission tomography with [18F]fluorodeoxyglucose
Pauwels, E. K. J., Sturm, E. J. C., Bombardieri, E., Cleton, F. J., & Stokkel, M. P. M. (2000) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/pl00008465 · Cited by 169 · see citing works
Tinazli, A., Tang, J., Valiokas, R., Pićurić, S., Lata, S., Piehler, J., Liedberg, B., & Tampé, R. (2005) · Chemistry - A European Journal · doi:10.1002/chem.200500154 · Cited by 155 · see citing works
Role for glucose transporter 1 protein in human breast cancer
Grover‐McKay, M., Walsh, S. A., Seftor, E. A., THOMAS, P. A., & Hendrix, M. J. C. (1998) · Pathology & Oncology Research · doi:10.1007/bf02904704 · Cited by 153 · see citing works
Positron emission tomography with 2-[18F]fluoro-2-deoxy-D-glucose in oncology
Ak, I., Stokkel, M. P. M., & Pauwels, E. K. J. (2000) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/pl00008466 · Cited by 152 · see citing works
Jiang, Y., Zhang, W., Kondo, K., Klco, J. M., Martin, T. B. S., Dufault, M. R., Madden, S. F., Kaelin, W. G., & Nacht, M. (2003) · PubMed · Cited by 124 · see citing works
Ito, T., Noguchi, Y., Satoh, S., Hayashi, H., Inayama, Y., & Kitamura, H. (1998) · PubMed · Cited by 123 · see citing works
Dorn, I. T., Neumaier, K. R., & Tampé, R. (1998) · Journal of the American Chemical Society · doi:10.1021/ja9735620 · Cited by 110 · see citing works
Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia
Funasaka, T., Yanagawa, T., Hogan, V. A., & Raz, A. (2005) · The FASEB Journal · doi:10.1096/fj.05-3699com · Cited by 93 · see citing works
Targeting delivery of paclitaxel into tumor cells via somatostatin receptor endocytosis
Huang, C., Wu, Y., & Chen, S.-T. (2000) · Chemistry & Biology · doi:10.1016/s1074-5521(00)00131-9 · Cited by 88 · see citing works
Kirschberg, T. A., VanDeusen, C. L., Rothbard, J. B., Yang, M., & Wender, P. A. (2003) · Organic Letters · doi:10.1021/ol035234c · Cited by 84 · see citing works
Hypoxia in head and neck cancer
Isa, A., Ward, T. H., West, C., Slevin, N. J., & Homer, J. J. (2006) · British Journal of Radiology · doi:10.1259/bjr/17904358 · Cited by 83 · see citing works
Synthesis and β-lactamase-mediated activation of a cephalosporin-taxol prodrug
Rodrigues, M. L., Carter, P. M., Wirth, C., Mullins, S., Lee, A. M., & Blackburn, B. K. (1995) · Chemistry & Biology · doi:10.1016/1074-5521(95)90272-4 · Cited by 69 · see citing works
Weekly, high‐dose paclitaxel in advanced lung carcinoma
Akerley, W., Herndon, J. E., Egorin, M. J., Lyss, A. P., Kindler, H. L., Savarese, D. M. F., Sherman, C. A., Rosen, D. M., Hollis, D. R., Ratain, M. J., et al. (2003) · Cancer · doi:10.1002/cncr.11375 · Cited by 61 · see citing works
Efficient Synthesis of Phospholipids from Glycidyl Phosphates
Lindberg, J., Ekeroth, J., & Konradsson, P. (2001) · The Journal of Organic Chemistry · doi:10.1021/jo010734+ · Cited by 59 · see citing works
Oncologic imaging in gynecologic malignancies.
Pandit-Taskar, N. D. (2005) · PubMed · Cited by 57 · see citing works
Liu, Y., Chen, G., Chen, Y., Dong-xu, C., Ge, Z.-Q., & Yuan, Y. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.08.040 · Cited by 53 · see citing works
Golik, J., Wong, H. S., Chen, S. H., Doyle, T. W., Wright, J. J. K., Knipe, J. O., Rose, W. C., Casazza, A. M., & Vyas, D. M. (1996) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/0960-894x(96)00321-6 · Cited by 41 · see citing works
Glyco‐SAMs as Glycocalyx Mimetics: Synthesis of L ‐Fucose‐ and D ‐Mannose‐Terminated Building Blocks
Kleinert, M., Röckendorf, N., & Lindhorst, T. K. (2004) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200400239 · Cited by 40 · see citing works
Wrasidlo, W., Gaedicke, G., Guy, R. K., Renaud, J., Pitsinos, E. N., Nicolaou, K. C., Reisfeld, R. A., & Lode, H. N. (2002) · Bioconjugate Chemistry · doi:10.1021/bc0200226 · Cited by 38 · see citing works
Longo, N., & Elsas, L. J. (1998) · Advances in Pediatrics · doi:10.1016/s0065-3101(23)00121-4 · Cited by 36 · see citing works
Preparation and Characterization of Water-Soluble Prodrug, Liposomes and Micelles of Paclitaxel
Dhanikula, A. B., & Panchagnula, R. (2005) · Current Drug Delivery · doi:10.2174/1567201052772861 · Cited by 28 · see citing works
Lee, J. W., & Fuchs, P. L. (1999) · Organic Letters · doi:10.1021/ol9905248 · Cited by 24 · see citing works
Coudoré, F., Authier, N., Guillaume, D., Béal, A., Duroux, E., & Fialip, J. (1999) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(98)00465-4 · Cited by 24 · see citing works
Hunt, D. K., & Seeberger, P. H. (2002) · Organic Letters · doi:10.1021/ol026276o · Cited by 18 · see citing works
Glucose uptake in the human gastric cancer cell line, MKN28, is increased by insulin stimulation
Noguchi, Y., Sato, S., Marat, D., Doi, C., Yoshikawa, T., Saito, A., Ito, T., Tsuburaya, A., & Yanuma, S. (1999) · Cancer Letters · doi:10.1016/s0304-3835(99)00054-3 · Cited by 13 · see citing works
Passardi, A., Massa, I., Zoli, W., Gianni, L., Milandri, C., Zumaglini, F., Nanni, O., Maltoni, R., Frassineti, G. L., & Amadori, D. (2006) · BMC Cancer · doi:10.1186/1471-2407-6-76 · Cited by 12 · see citing works
Flagged first, then by citations
1 of the 39 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Glucose Conjugation for the Specific Targeting and Treatment of Cancer
Calvaresi, E. C., & Hergenrother, P. J. (2013) · Chemical Science · doi:10.1039/c3sc22205e · Cited by 398 · see citing works
Prodrugs in medicinal chemistry and enzyme prodrug therapies
Walther, R., Rautio, J., & Zelikin, A. N. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.06.013 · Cited by 293 · see citing works
Iron as a central player and promising target in cancer progression
Jung, M., Mertens, C., Tomat, E., & Brüne, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020273 · Cited by 268 · see citing works
Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules
Gantt, R. W., Peltier, P., & Thorson, J. S. (2011) · Natural Product Reports · doi:10.1039/c1np00045d · Cited by 245 · see citing works
Small Molecules for Active Targeting in Cancer
Kue, C. S., Kamkaew, A., Burgess, K., Kiew, L. V., Chung, L. Y., & Lee, H. B. (2016) · Medicinal Research Reviews · doi:10.1002/med.21387 · Cited by 143 · see citing works
Probing the Aglycon Promiscuity of an Engineered Glycosyltransferase
Gantt, R. W., Goff, R. D., Williams, G. J., & Thorson, J. S. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200803508 · Cited by 135 · see citing works
Medicinal Chemistry of Paclitaxel and its Analogues
Fu, Y., Li, S., Zu, Y., Yang, G., Yang, Z., Luo, M., Jiang, S., Wink, M., & Efferth, T. (2009) · Current Medicinal Chemistry · doi:10.2174/092986709789352277 · Cited by 130 · see citing works
Targeting the Delivery of Glycan-Based Paclitaxel Prodrugs to Cancer Cells via Glucose Transporters
Lin, Y.-S., Tungpradit, R., Sinchaikul, S., An, F.-M., Liu, D.-Z., Phutrakul, S., & Chen, S.-T. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm8006257 · Cited by 120 · see citing works
Self-citationVasudevan, U. M., & Lee, E. Y. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2020.107550 · Cited by 104 · see citing works
Prodrug Strategies for Paclitaxel
Meng, Z., Lv, Q., Lu, J. G., Yao, H., Lv, X., Jiang, F., Lü, A., & Zhang, G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050796 · Cited by 93 · see citing works
Anticancer agents interacting with membrane glucose transporters
Granchi, C., Fortunato, S., & Minutolo, F. (2016) · MedChemComm · doi:10.1039/c6md00287k · Cited by 71 · see citing works
Glycoconjugates for glucose transporter-mediated cancer-specific targeting and treatment
Fu, J., Yang, J., Seeberger, P. H., & Yin, J. (2020) · Carbohydrate Research · doi:10.1016/j.carres.2020.108195 · Cited by 73 · see citing works
Rale, M., Schneider, S., Sprenger, G. A., Samland, A. K., & Fessner, W. (2011) · Chemistry - A European Journal · doi:10.1002/chem.201002942 · Cited by 61 · see citing works
Li, J., Ma, F. K., Dang, Q., Liang, X., & Chen, X. (2014) · Frontiers of Materials Science · doi:10.1007/s11706-014-0262-8 · Cited by 57 · see citing works
Arévalo‐Ruiz, M., Doria, F., Belmonte‐Reche, E., Rache, A. D., Campos‐Salinas, J., Lucas, R., Falomir, E., Cardá, M., Pérez-Victoria, J. M., Mergny, J., et al. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201604886 · Cited by 57 · see citing works
Programmable selective acylation of saccharides mediated by carbene and boronic acid
Lv, W., Chen, H., Zhang, X., Ho, C. C., Liu, Y., Wu, S., Wang, H., Jin, Z., & Chi, Y. R. (2022) · Chem · doi:10.1016/j.chempr.2022.04.019 · Cited by 48 · see citing works
Enhancing the Divergent Activities of Betulinic Acid via Neoglycosylation
Goff, R. D., & Thorson, J. S. (2008) · Organic Letters · doi:10.1021/ol8025704 · Cited by 44 · see citing works
Synthesis of new triazole linked carbohybrids with ROS-mediated toxicity in breast cancer
Kumari, P., Dubey, S., Venkatachalapathy, S., Narayana, C., Gupta, A. K., & Sagar, R. (2019) · New Journal of Chemistry · doi:10.1039/c9nj03288f · Cited by 39 · see citing works
A Small Sugar Molecule with Huge Potential in Targeted Cancer Therapy
Pastuch-Gawołek, G., Szreder, J., Domińska, M., Pielok, M., Cichy, P., & Grymel, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030913 · Cited by 36 · see citing works
Engineering Targeting Materials for Therapeutic Cancer Vaccines
Briquez, P. S., Hauert, S., de Titta, A., Gray, L. T., Alpar, A. T., Swartz, M. A., & Hubbell, J. A. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00019 · Cited by 32 · see citing works
Extracellular-protein-enhanced cellular uptake of squalenoyl gemcitabine from nanoassemblies
Bildstein, L., Marsaud, V., Chacun, H., Lepêtre‐Mouelhi, S., Desmaële, D., Couvreur, P., & Dubernet, C. (2010) · Soft Matter · doi:10.1039/c0sm00342e · Cited by 32 · see citing works
Identification of gallic acid based glycoconjugates as a novel tubulin polymerization inhibitors
Upadhyaya, K., Hamidullah, H., Singh, K., Arun, A., Shukla, M. K., Srivastava, N., Ashraf, R., Sharma, A., Mahar, R., Shukla, S. K., et al. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob02113h · Cited by 31 · see citing works
Xiao, Z., Gu, Y., Dong, H., Liu, B., Jin, W., Li, J., Ma, P., Xu, H., & Hou, W. (2023) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2023.100113 · Cited by 30 · see citing works
Glycosylated nordihydroguaiaretic acids as anti-cancer agents
Hwu, J. R., Hsu, C.-I., Hsu, M., Liang, Y., Huang, R. C. C., & Lee, Y. C. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.10.137 · Cited by 24 · see citing works
Chen, Y., Liao, X., Jing, P., Hu, L., Yang, Z., Yao, Y., Liao, C., & Zhang, S. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00333 · Cited by 22 · see citing works
Abolhasani, A., Biria, D., Abolhasani, H., Zarrabi, A., & Komeili, T. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s228652 · Cited by 22 · see citing works
A New NT4 Peptide-Based Drug Delivery System for Cancer Treatment
Brunetti, J., Piantini, S., Fragai, M., Scali, S., Cipriani, G., Depau, L., Pini, A., Falciani, C., Menichetti, S., & Bracci, L. (2020) · Molecules · doi:10.3390/molecules25051088 · Cited by 21 · see citing works
“Sweet tooth”-oriented SN38 prodrug delivery nanoplatform for targeted gastric cancer therapy
Ding, N., Xu, S., Zheng, S., Ye, Q., Xu, L. L., Ling, S., Xie, S., Chen, W., Zhang, Z., Xue, M., et al. (2021) · Journal of Materials Chemistry B · doi:10.1039/d0tb02787a · Cited by 19 · see citing works
Probing the Aglycon Promiscuity of an Engineered Glycosyltransferase
Gantt, R. W., Goff, R. D., Williams, G. J., & Thorson, J. S. (2008) · Angewandte Chemie · doi:10.1002/ange.200803508 · Cited by 18 · see citing works
Pathway elucidation and engineering of plant-derived diterpenoids
Shao, J., Sun, Y.-W., Liu, H., & Wang, Y. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.08.007 · Cited by 16 · see citing works
A branched small molecule-drug conjugate nanomedicine strategy for the targeted HCC chemotherapy
Li, S., Zhang, C., Wu, J., Liu, C., & Liu, Z. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.114037 · Cited by 16 · see citing works
Tiwari, G., Mishra, V. K., Kumari, P., Khanna, A., Sharma, S., & Sagar, R. (2024) · RSC Advances · doi:10.1039/d3ra06993a · Cited by 15 · see citing works
Bennai, N., Chabrier, A., Fatthalla, M. I., Tran, C., Yen‐Pon, E., Belkadi, M., Alami, M., Grimaud, L., & Messaoudi, S. (2020) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.0c00766 · Cited by 15 · see citing works
Synthesis of rapamycin glycoconjugates via a CuAAC-based approach
Moni, L., Marra, A., Skotnicki, J. S., Koehn, F. E., Abou-Gharbia, M. A., & Dondoni, A. (2013) · Tetrahedron Letters · doi:10.1016/j.tetlet.2013.10.026 · Cited by 15 · see citing works
Role of Glucose Transporters in Drug Membrane Transport
Wang, X., Guo, K., Huang, B., Lin, Z., & Cai, Z. (2020) · Current Drug Metabolism · doi:10.2174/1389200221666200810125924 · Cited by 13 · see citing works
Glycoconjugated Site-Selective DNA-Methylating Agent Targeting Glucose Transporters on Glioma Cells
Buchanan, M. K., Needham, C. N., Neill, N. E., White, M. C., Kelly, C. B., Mastro-Kishton, K., Chauvignè-Hines, L. M., Goodwin, T. J., McIver, A. L., Bartolotti, L. J., et al. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b01075 · Cited by 13 · see citing works
Tiwari, G., Khanna, A., Tyagi, R., Mishra, V. K., Narayana, C., & Sagar, R. (2024) · Scientific Reports · doi:10.1038/s41598-023-50202-4 · Cited by 12 · see citing works
Meng, X., Lian, X., Li, X., Ya, Q., Li, T., Zhang, Y., Yang, Y., & Zhang, Y. (2020) · Carbohydrate Research · doi:10.1016/j.carres.2020.108034 · Cited by 12 · see citing works
Ocal, N., Arbia, G., Lagarde, A., Joly, M., Gittings, S., Graham, K. M., Charmantray, F., & Hecquet, L. (2022) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.202201190 · Cited by 11 · see citing works
Tsepaeva, O. V., Nemtarev, A. V., Pashirova, T. N., Khokhlachev, M. V., Lyubina, A. P., Amerkhanova, S. K., Voloshina, A. D., & Mironov, V. F. (2023) · RSC Medicinal Chemistry · doi:10.1039/d2md00363e · Cited by 9 · see citing works
Cell line studies and analytical measurements of three paclitaxel complex variations
Manning, T. J., Plummer, S., Woods, R., Wylie, G., Phillips, D. R., & Krajewski, L. C. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.04.070 · Cited by 7 · see citing works
Hilali, M. E., Reux, B., Débiton, E., Leal, F., Galmier, M., Vivier, M., Chezal, J., Miot-Noirault, E., Coudert, P., & Weber, V. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.08.043 · Cited by 6 · see citing works
Clathrin light chain‐conjugated drug delivery for cancer
Jung, S., Jiang, L., Zhao, J., Shultz, L. D., Greiner, D. L., Bae, M., Li, X., Ordikhani, F., Kuai, R., Joseph, J., et al. (2021) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10273 · Cited by 4 · see citing works
Developing Ligands to Target Transition Metals in Cancer
Utterback, R. D., & Tomat, E. (2019) · Wiley eBooks · doi:10.1002/9781119951438.eibc2694 · Cited by 3 · see citing works
Synthesis and anticancer potential of glycosides
Ali, S., Rukh, G., Ogaly, H. A., Ajaj, R., Rauf, A., & Shah, S. A. A. (2025) · RSC Advances · doi:10.1039/d5ra07626a · Cited by 2 · see citing works
Feng, S., Chen, K., Wang, C., Jiang, X., Dong, H., Gong, Z., & Liu, K. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.06.012 · Cited by 2 · see citing works
Hossain, F., Nishat, S., & Andreana, P. R. (2022) · Peptide Science · doi:10.1002/pep2.24260 · Cited by 2 · see citing works
Lipopolyplex-based delivery system for cancer vaccine delivery
Kaur, J., Taleuzzaman, M., Das, V., & Singh, A. D. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823686-4.00013-6 · Cited by 1 · see citing works
Yang, C. (2008) · VTechWorks (Virginia Tech)
Singh, K., Shukla, A., Bablu, B., Dubey, M., Khanna, A., & Sagar, R. (2026) · Synlett · doi:10.1055/a-2863-4671
Jia, M., Zhang, R., Liu, Y., Gao, X., Li, Z., Xu, J., Liu, S., & Gao, Q. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.110289
Das, R., Basumatary, J., Roy, B., Mukherjee, D., & Kundu, T. (2026) · Chemical Communications · doi:10.1039/d6cc05273h
- Authors
- Liu, D.-Z., Sinchaikul, S., Reddy, P. V. G., Chang, M.-Y., & Chen, S.-T.
- Affiliations
- Taipei Medical University (TW)
- Genomics Research Center, Academia Sinica (TW)
- National University of Kaohsiung (TW)
- National Taiwan University (TW)
- Corresponding author
- Chen, Shui-Tein
- Venue
- Bioorganic & Medicinal Chemistry Letters
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 17
- Issue
- 3
- Pages
- 617-620
- ISSN
- 0960-894X (ISSN-L)
- OpenAlex
- W1993868850
- Cited by
- 53
- References
- 39
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 8 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 6 · 2015: 1 · 2014: 1 · 2013: 2
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioorganic & Medicinal Chemistry Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Keywords
- paclitaxel, glucose conjugation, targeted drug delivery, glucose transporters, MCF-7 cells, selective cytotoxicity
- MeSH terms
- Antineoplastic Agents, Phytogenic, Cell Membrane, Chemistry, Physical, Chromatography, High Pressure Liquid, Humans, Indicators and Reagents, Neoplasms, Solubility, Succinates, Paclitaxel, Cell Line, Tumor, Glucose Transport Proteins, Facilitative, Chemical Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
