The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The use of spirocyclic scaffolds in drug discovery
Open accessAbstract
Owing to their inherent three-dimensionality and structural novelty, spiro scaffolds have been increasingly utilized in drug discovery. In this brief review, we highlight selected examples from the primary medicinal chemistry literature during the last three years to demonstrate the versatility of spiro scaffolds. With recent progress in synthetic methods providing access to spiro building blocks, spiro scaffolds are likely to be used more frequently in drug discovery.
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Citations
Cites
Molecular properties that influence the oral bioavailability of drug candidates
Veber, D. F., Johnson, S. R., Cheng, H.-Y., Smith, B. R., Ward, K. W., & Kopple, K. D. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm020017n · Cited by 8,420
Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a
Sweis, R. F., Pliushchev, M., Brown, P. J., Guo, J., Li, F., Maag, D., Petros, A. M., Soni, N. B., Tse, C., Vedadi, M., et al. (2014) · ACS Medicinal Chemistry Letters · doi:10.1021/ml400496h · Cited by 193
Yuan, J., Venkatraman, S., Zheng, Y., McKeever, B. M., Dillard, L. W., & Singh, S. B. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm301659n · Cited by 135
Self-citationBhattacharya, S. K., Andrews, K., Beveridge, R., Cameron, K. O., Chen, C., Dunn, M., Fernando, D., Gao, H., Hepworth, D., Jackson, V. M., et al. (2014) · ACS Medicinal Chemistry Letters · doi:10.1021/ml400473x · Cited by 73
Cited by
Catalytic Enantioselective Construction of Spiro Quaternary Carbon Stereocenters
Xu, P.-W., Yu, J.-S., Chen, C., Cao, Z.-Y., Zhou, F., & Zhou, J. (2019) · ACS Catalysis · doi:10.1021/acscatal.8b03694 · Cited by 325
All-carbon quaternary centers in natural products and medicinal chemistry: recent advances
Ling, T., & Rivas, F. (2016) · Tetrahedron · doi:10.1016/j.tet.2016.09.002 · Cited by 312
Metadata
- Authors
- Zheng, Y., Tice, C. M., & Singh, S. B.
- Venue
- Bioorganic & Medicinal Chemistry Letters
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 24
- Issue
- 16
- Pages
- 3673-3682
- ISSN
- 0960-894X (ISSN-L)
- OpenAlex
- W2029526231
- Cited by
- 1,036
- References
- 4
- FWCI
- 18.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zheng, Y., Tice, C. M., & Singh, S. B. (2014). The use of spirocyclic scaffolds in drug discovery. Bioorganic & Medicinal Chemistry Letters. https://doi.org/10.1016/j.bmcl.2014.06.081
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
