Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer
Open accessAbstract
The incidence of skin cancers such as non-melanoma skin cancer and malignant melanoma has increased in the last few years mainly because of chronic exposure to ultraviolet (UV) radiation. Sunscreens protect the skin against harmful UV radiations; however, some limitations of these products justify the discovery of new UV filters. Novel 1,3,5-triazine derivatives (12a-h) obtained by the optimization of prototype resveratrol were synthesized and characterized. All compounds exhibited sun protection factor (SPF) and UVA protection factor (UVAPF) in the range of 3-17 and 3-13, respectively. These values were superior to resveratrol and the UV filter ethylhexyl triazone (EHT) currently available on the market. In addition, all compounds demonstrated in vitro antioxidant activity and thermal stability with the decomposition at temperatures above 236 °C. In conclusion, the novel 1,3,5-triazine derivatives have emerged as new UV filters with antioxidant effect useful to prevent skin cancer.
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Among 1,3,5-triazine derivatives 90-97, compound 97 displayed the most promising antioxidant activity and revealed the highest SPF and UVA protection factor.
“Among 1,3,5-triazine derivatives 90–97, 97 displayed the most promising antioxidant activity and revealed the highest SPF and UVA protection factor [25].”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [25]
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References 24 · Cited by 15
- Authors
- Reis, J. S., Corrêa, M. A., Ribeiro, C. A., & Dos Santos, J. L.
- Affiliations
- Universidade Estadual Paulista (Unesp) (BR)
- Venue
- Bioorganic & Medicinal Chemistry Letters
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 29
- Issue
- 24
- Pages
- 126755
- ISSN
- 0960-894X (ISSN-L)
- OpenAlex
- W2982386919
- Cited by
- 15
- References
- 24
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 1
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Bioorganic & Medicinal Chemistry Letters (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (430172/2018-4)
- Fundação de Amparo à Pesquisa do Estado de São Paulo (18/11079-0)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and Characterization of Heterocyclic Compounds
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Keywords
- 1,3,5-triazine derivatives, sunscreen, UV filters, resveratrol derivatives, sun protection factor, UVA protection factor, antioxidant activity, thermal stability, skin cancer prevention, non-melanoma skin cancer, melanoma, ultraviolet radiation
- MeSH terms
- Antioxidants, Humans, Skin Neoplasms, Sunscreening Agents, Triazines
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