The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Role of iron metabolism and oxidative damage in postmenopausal bone loss
Open accessAbstract
It has been suggested that iron-deficient rats have lower bone mass than iron-replete animals, but a clear association between bone and iron repletion has not been demonstrated in humans. A growing body of evidences also suggests a relation between lipid oxidation and bone metabolism and between iron metabolism and LDL oxidation. Iron availability to cells also depends on haptoglobin (Hp) phenotypes. Hp has also important antioxidant properties according to its phenotype, hence we evaluate whether Hp phenotype could influence bone density, iron metabolism and lipid oxidation. This cross-sectional study enrolled 455 postmenopausal women affected by osteoporosis (260) or not (195). Bone mineral density, markers of bone and iron metabolism, levels of oxidized LDL (oxLDL) and Hp phenotype were measured in all the subjects. Hp 1.1 and 2.2 frequency was higher and Hp 2.1 was lower in the patients with fragility fractures (80) compared with the controls. We therefore evaluate different Hp phenotypes as risk or protective factors against fragility fracture: Hp 2.1 is a protective factor against fracture while 1.1 is an important and 2.2 a moderate risk factor for fragility fractures. Lower serum iron was associated with elevated transferrin in patients with Hp 1.1; moreover patients had relative iron deficiency compared with the controls and fractured patients had higher level of oxLDL. We found that both iron metabolism and oxLDL varies according to Hp phenotypes and are predictive of bone density. Our data indicate that Hp 2.1 is a protective factor for fragility fractures, depending on its role on iron metabolism and its antioxidant properties.
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“D'Amelio et al., (2008) observed that patients with osteoporosis were iron deficient, had lower serum iron and higher Tf levels.”
From Iron, Oxidative Stress and Health (2012) · cites this paper as D'Amelio et al., (2008)
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Cited by
The regulation of iron metabolism by hepcidin contributes to unloading-induced bone loss
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Metadata
- Authors
- D'Amelio, P., Cristofaro, M. A., Tamone, C., Morra, E., Di Bella, S., Isaia, G., Grimaldi, A., Gennero, L., Gariboldi, A., Ponzetto, A., Pescarmona, G. P., & Isaia, G. C.
- Affiliations
- University of Turin (IT)
- Azienda Ospedaliero Universitaria San Giovanni Battista (IT)
- ORCID
- Ponzetto, Antonio
- Venue
- Bone
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 43
- Issue
- 6
- Pages
- 1010-1015
- ISSN
- 1873-2763 (ISSN-L)
- 8756-3282
- OpenAlex
- W2114196437
- Cited by
- 70
- References
- 28
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 4
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Bone (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Funders
- Compagnia di San Paolo
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Regione Piemonte
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- iron metabolism, oxidative damage, postmenopausal bone loss, haptoglobin phenotypes, osteoporosis, fragility fractures, oxidized LDL, lipid oxidation, bone mineral density, iron deficiency, transferrin, antioxidant activity
- MeSH terms
- Aged, Cross-Sectional Studies, Female, Humans, Iron, Lipoproteins, LDL, Middle Aged, Osteoporosis, Risk Factors, Blotting, Western, Bone Density, Postmenopause, Oxidative Stress
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