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Biological and clinical significance of haptoglobin polymorphism in humans
Abstract
Haptoglobin is a hemoglobin-binding protein expressed by a genetic polymorphism as three major phenotypes: 1-1, 2-1, and 2-2. Most attention has been paid to determining haptoglobin phenotype as a genetic fingerprint used in forensic medicine. More recently, several functional differences between haptoglobin phenotypes have been demonstrated that appear to have important biological and clinical consequences. Haptoglobin polymorphism is associated with the prevalence and clinical evolution of many inflammatory diseases, including infections, atherosclerosis, and autoimmune disorders. These effects are explained by a phenotype-dependent modulation of oxidative stress and prostaglandin synthesis. Recent evidence is growing that haptoglobin is involved in the immune response as well. The strong genetic pressure favoring the 2-2 phenotype suggests an important role of haptoglobin in human pathology.
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Cited by
Schaer, D. J., Schaer, C. A., Buehler, P. W., Boykins, R. A., Schoedon, G., Alayash, A. I., & Schaffner, A. (2006) · Blood · doi:10.1182/blood-2005-03-1014 · Cited by 285
The Redox Activity of Hemoglobins: From Physiologic Functions to Pathologic Mechanisms
Reeder, B. J. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2974 · Cited by 189
Vitamin E in the prevention of cardiovascular disease: the importance of proper patient selection
Vardi, M., Levy, N. S., & Levy, A. P. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r026641 · Cited by 98
Peroxidase Activity of Hemoglobin·Haptoglobin Complexes
Kapralov, A., Vlasova, I. I., Feng, W., Maeda, A., Walson, K., Tyurin, V. A., Huang, Z., Aneja, R. K., Carcillo, J., Bayır, H., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.045567 · Cited by 96
De Bacquer, D., Clays, E., Delanghe, J., & De Backer, G. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.12.028 · Cited by 78
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Metadata
- Authors
- Langlois, M. R., & Delanghe, J. R.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-10-01
- Volume
- 42
- Issue
- 10
- Pages
- 1589-1600
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W1926159205
- Cited by
- 930
- References
- 0
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Langlois, M. R., & Delanghe, J. R. (1996). Biological and clinical significance of haptoglobin polymorphism in humans. Clinical Chemistry. https://doi.org/10.1093/clinchem/42.10.1589
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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