Cellular senescence in bone

Cited by (263)

Items 201–263 of 263

1. Comprehensive analysis of ferroptosis-related genes reveals potential therapeutic targets in osteoporosis patients: a computational analysis and in vitro experiments
   Sihui Chen, Yiyi Jiang, Guoqin Xie, Peng Wu, Jinyu Zhu · 2025 · Frontiers in Genetics
2. Senotherapeutic approach to age-related endocrine diseases
   Şeydanur Turgut, Gülnur Andican · 2025 · Advances in pharmacology
3. The balance among radiation-induced cell death pathways in the p53-mutant human glioblastoma cell line T98G: A preliminary study
   Hisashi Nakano, Juri KIDACHI, Mitsuki IMAZATO, Mizuki KOJIMA, Kaori Tsutsumi · 2025 · Biomedical Research
4. Kangshujiangu granules improve NAFLD via cross-organ autophagy activation shared with osteoporosis
   Na Wang, Li Song, Yue Peng, Langqiu Wei, Zhaofan Long, Che Wang, Qiling Liu, Chuandao Shi · 2025 · Frontiers in Pharmacology
5. Age-related functional deterioration of medullary bone is linked with senescent bone marrow microenvironment in laying hens
   Xujie Liao, Aoze Wang, Shutong Wang, Wanting Zhao, Jionghao Chen, Nan Wang, Menglin Wang, Jiakun Yan, Yanli Liu, Xin Yang et al. · 2025 · Journal of Integrative Agriculture
6. EndoCompass Project: Research Roadmap for Calcium and Bone Endocrinology
   Katharina Jähn, Karin Zibar Tomšić, Athanasios D. Anastasilakis, Jean‐Philippe Bertocchio, Maria Luisa Brandi, Martin Faßnacht, Moira Cheung, Evelien F. Gevers, Neil J. L. Gittoes, Outi Mäkitie et al. · 2025 · Hormone Research in Paediatrics
7. Black Phosphorus Nanomaterials and the Senescent Osteoimmune Microenvironment: Mechanisms, Opportunities, Challenges, and Future Outlook
   Jiawen Wang, Jian-Jun Xun, Fei-Fei Zhao · 2026 · International Journal of Nanomedicine
8. The role of senescence in the development of osteoporosis and osteoarthritis
   Kveta Kroupova, Vladimír Palička · 2023 · Clinical Osteology
9. Murine Progeria Model Exhibits Delayed Fracture Healing With Senescent Phenotype and Dysregulated Immune Response
   Victoria R. Duke, Marc J. Philippon, Dane R.G. Lind, Herbert G. Kasler, Kohei Yamaura, Matt Huard, Molly E. Czachor, Justin F.M. Hollenbeck, Justin Brown, Alex Garcia et al. · 2026 · Journal of Orthopaedic Research®
10. Restoration of macrophage mitochondrial dynamics and trafficking with enzymatic magnesium-manganese layered double hydroxide for osteoporotic therapy
    Wenwen Mao, Kehan Wang, Jingxian Mao, Zhuobin Xu, Chun Pan, Dandan Li, Tingting Liu, Hao Chen, Huihui Wang, Cheng Huang et al. · 2026 · Journal of Nanobiotechnology
11. Slowing intervertebral disc aging in mice through long-term systemic treatment with the senolytic BCL-2/BCL-xL proteolysis targeting chimera (PROTAC) 753b
    Peter Geoffrey Alexander, Bowen Yan, Karen L. Clark, Qing D. Dong, D Wang, Yang Yang, Ting Zhang, Peiyi Zhang, Guangrong Zheng, Paul D. Robbins et al. · 2026 · Aging
12. Rewiring osteoimmune homeostasis in osteoporosis: T-cell subsets as key regulators and emerging therapeutic targets
    Yuan Gong, Wenxing Zeng, Yitao Liao, Xuanyu Xie, Zhichao Qin, Chao Li, Xian Zhang · 2026 · Frontiers in Immunology
13. Interventional Strategies to Delay Aging-Related Dysfunctions of the Musculoskeletal System
    Naomasa Fukase, Ingrid Kvello Stake, Yoichi Murata, William S. Hambright, Sudheer K. Ravuri, Marc J. Philippon, Johnny Huard · 2021 · IntechOpen eBooks
14. A geroscience approach for osteosarcopenia: Autophagy and senescence as therapeutic targets
    Natanael Perez Cordero, Patricia V. Schoenlein, Sadanand Fulzele, William Hill · 2022 · Elsevier eBooks
15. Functional foods in improving bone health during aging
    Suphachai Charoensin, Peraphan Pothacharoen, Orawan Wanachewin, Prachya Kongtawelert, Maitree Suttajit · 2022 · Elsevier eBooks
16. Molecular basis of DNA damage response (DDR) pathway in periodontitis: pathogenic mechanisms and therapeutic directions
    S. S. P. Reddy, D. Francis, Anitha Logaranjani, Anirudha Agnihotry, Shaili Pradhan, S. Anil · 2025 · Periodontal and Implant Research
17. Evolution of Concepts Concerning Significance of Hydrogen Sulfide in Age-Dependent Pathology Development
    Голубкина Екатерина Валерьевна, Тризно Матвей Николаевич, Дюкарева Оксана Сергеевна, Тризно Николай Николаевич, Лина Юрьевна Лагуткина · 2021 · ВЕСТНИК ОБРАЗОВАНИЯ И РАЗВИТИЯ НАУКИ РОССИЙСКОЙ АКАДЕМИИ ЕСТЕСТВЕННЫХ НАУК
18. Bone Microarchitecture Alterations Are Associated With the TP53 Arg72Pro Polymorphism
    Ricardo Usategui‐Martín, Nadia Galindo‐Cabello, Salvador Pastor‐Idoate, José María Fernández-Gómez, Álvaro del Real, Diego Ferreño, Rebeca Lapresa, Francisco Martín Rodríguez, José A Riacho, Ángeles Almeida et al. · 2023 · Preprints.org
19. Meeting report from the 3rd IFMRS/KU Leuven Herbert Fleisch Workshop, Brugge, Belgium, 17–19 March 2019
    Christa Maes, Roger Bouillon, Thomas John Martin · 2019 · Bone
20. Restoring mechano-adaptation in aged murine bone
    Judith Piet · 2019
21. Cellular senescence by loss of Men1 in osteoblasts is critical for age-related osteoporosis
    Takashi Kaito, Yuichiro Ukon, Hiromasa Hirai, Takayuki Kitahara, Masayuki Bun, Joe Kodama, Daisuke Tateiwa, Shinichi Nakagawa, Masato Ikuta, Takuya Furuichi et al. · 2023 · Research Square
22. Cellular senescence as a pathogenic factor and potential therapeutic target in osteoporosis
    Lorena Pena Larrea, Manuela de Blas Rodríguez, Manuel Naves‐Díaz, Carlos Gómez Alonso · 2023 · Revista de Osteoporosis y Metabolismo Mineral
23. Young BMSC-derived extracellular vesicles containing lncRNA sponging miR-1843a-5p to regulate Mob3a/YAP axis promote osteogenesis of senescent BMSCs
    Lei Qi, Cancan Pan, Jinge Yan, Weiwen Ge, Lu Liu, Hanjiang Zhao, Jing Wang, Lei Zhang, Dan Lin, Steve GF Shen · 2023 · Research Square
24. Biomimetic Therapeutics for Bone Regeneration: A Perspective on Antiaging Strategies
    Jacob M. Miszuk, Hongli Sun · 2023 · Macromolecular Bioscience
25. Dinâmica da polarização de macrófagos e o impacto de sua modulação no processo de reparo ósseo alveolar
    André Petenuci Tabanêz · 2023
26. Mesoporous Bioactive Glass Scaffolds Delivering BMSCs Osteoinductive EVs lncRNA Promote Senescent Bone Defect Repair by Targeting the miR-1843a-5p/mob3a/YAP Axis
    Lei Qi, Cancan Pan, Jinge Yan, Weiwen Ge, Jing Wang, Lu Liu, Lei Zhang, Dan Lin, Steve GF Shen · 2023 · SSRN Electronic Journal
27. Unraveling the Power of Extracellular Matrix to Rescue the Effect of Aging
    Marta S. Carvalho · 2024 · Elsevier eBooks
28. Research Progress in Targeting Senescent Cells in the Treatment of Osteoarthritis
    鹏 王 · 2024 · Advances in Clinical Medicine
29. Spatial analysis of the bone microenvironment reveals a novel osteoblast-CD4+ CTL crosstalk mediated by the SIRT1/DAAM2 axis
    yong-xiang wang, Lei Wang, Hao Chen, Bin Yang, guo-fu zhang, Jingcheng Wang, Wenyong Fei, Jun Cai, Binjia Ruan, Zhengwei Liu et al. · 2024 · Research Square
30. Features of Densitometric Assessment of Bone Tissue in Young Patients with Hodgkin’s Lymphoma
    K.M. Badykova, Yu. S. Kitaeva, Evgeniy A. Praskurnichiy · 2024 · The Russian Archives of Internal Medicine
31. Cellular senescence as a key factor in osteoporosis: the role of SIRT1
    Angela Falvino, Ida Cariati, Roberto Bonanni, Beatrice Gasperini, Angela Chiavoghilefu, Annalisa Botta, Virginia Tancredi, Umberto Tarantino · 2024 · International Journal of Bone Fragility
32. Stiffening Symphony of Aging: How Senescent Osteocytes Lose Their Elastic Rhythm
    Maryam Tilton, Megan Moore Weivoda, Maria D. Astudillo Potes, Anne Gingery, Alan Y. Liu, Tamar Tchkonia, Li‐Chun Lu, James L. Kirkland · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
33. Musculoskeletal biomarkers in health and disease: implications for the aging spine—a review for spinal surgeons by the SRS adult spinal deformity task force on senescence
    Tej Deepak Azad, M. Li, Ping-Yeh Chiu, Kristen E. Jones, Elizabeth L. Lord, Camilo A. Molina, Corey T. Walker, Joseph A. Osorio, Javier Pizones, Alekos A. Theologis et al. · 2025 · Spine Deformity
34. Integrated Bioinformatics Analysis and Experimental Validation of the Role of Cellular Senescence in Osteoporosis
    Peiwen Wang, Xiping Hu, Chunqing Han, Yuanjin Chang, Ruijin Xie, Junxing Ye, Yu Wu · 2025 · Calcified Tissue International
35. Hindlimb unloading results in accelerated bone loss compared to aging in select bone compartments of female murine femurs
    Steven J. Meas, Gabriella M. Daire, Evan G. Buettmann, Henry J. Donahue · 2025 · Journal of Biomechanics
36. Endothelin-1/endothelin B receptor signalling mediates Prx1+ skeletal stem cells senescence: A driver of osteoporotic bone loss
    Zhou Zou, Weiyuan Gong, Xuan Lu, Yuqi Zhang, Man Ting Au, Junxin Lin, Hongwei Ouyang, Guozhi Xiao, Bin Hong Tang, Chunyi Wen · 2026 · Journal of Orthopaedic Translation
37. Biomarkers of cellular senescence in bone tissue
    Volodymyr I. Ostrianko, Inessa I. Yakubova, Victor Dosenko, Roman I. Andriiashyk · 2026 · Polski Merkuriusz Lekarski
38. Assessment of Bone Mineral Density in Patients With Degenerative Spinal Disease by MRI-based Vertebral Bone Quality Score at Different Lumbar Vertebral Levels
    Youwei Ai, Ce Zhu, Juehan Wang, Hong Q. Ding, Qingyi Zhang, Yongdi Wang, Zhuojie Xiao, Xingyu Shao, Lechuan Zhu, Yueming Song et al. · 2026 · Spine
39. CCAR2 reduces the number of osteoclasts by controlling osteoclast apoptosis
    Junyue Zhang, Yiping Song, Si Chen, Kyu Yun Jang, Jung Ryul Kim, Young Jae Moon · 2026 · Acta Biochimica et Biophysica Sinica
40. Osteoblastic cell senescence and their contribution to metabolic bone diseases
    Eva Maria Wölfel, Florence Figeac, Paula Fernandez Guerra, Mikkel Ørnfeldt Nørgård, Shakespeare Jeromdesella, Pernille Kirkegaard Kjær, Anna Sofie Elkjaer, Moustapha S Kassem · 2026 · Elsevier eBooks
41. Ginsenoside Rh2 alleviates osteoporosis by attenuating oxidative stress-induced osteoblast dysfunction via the FoxO1/β-catenin pathway
    Wenqi Jin, Yujing Tan, Xuenan Chen, Zehan Guo, Jixiang Ren, Liwei Sun · 2026 · Acta Biochimica et Biophysica Sinica
42. Effet des peptides alimentaires sur le développement osseux des poissons
    Aliki Printzi · 2023
43. Pharmacological modulation of ferroptosis across diverse osteoporosis etiologies: a stratified meta-analysis of preclinical interventions
    Sayed Abdulla Jami, Ernest Dapaah, Peifeng Hong, Hu Jiamao, Md. Tofazzale Hosain · 2026 · Next research.
44. Senotherapeutics for Knee Osteoarthritis
    Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva · 2026 · Medicinal Research Reviews
45. Inflammation driven by NF-ĸB compromises bone formation by inducing the differentiation of osteoblasts into atypical inflammatory osteocyte-like cells
    Gaurav Swarnkar, Md Fahim Ahmad, Marwa Zeyad, Abdul Malik Tyagi, Musarrat Naaz, Gabriel Mbalaviele, Yousef Abu‐Amer · 2026 · Bone Research
46. Loss of EGFR activity in skeletal stem/progenitor cells is associated with impaired fracture healing in aged mice
    Yuxiang Hu, Yi Wang, Yangyang Chen, Xiaoyao Peng, Hang Chu, Guosilang Zuo, Fashuai Wu, Min Cui, Zengwu Shao, Yulong Wei · 2026 · Bioactive Materials
47. Bone as a Biomarker of Ageing and Senescence: Connecting Musculoskeletal Health to Longevity via Diet, Nutrition and Exercise
    Hannah Beaumont, Sam Guest, Shelly Pathak, Yashaswini Premjit, Elena Jones, Payal Ganguly · 2026 · Biology
48. Immune ageing in skeletal fragility: clonal haematopoiesis and failure of inflammatory resolution during fracture repair
    Yong He, XU Hong-bin, Jin Huang, Tian-peng Liu, Hai‐Feng Jia, Yi Shen, Furui Fu, Jie Wang, Meng-ting YUAN, Wei Xin et al. · 2026 · Frontiers in Immunology
49. 3D- and 4D-printed scaffolds for osteoporotic bone regeneration: translational insights from in vivo preclinical and human-oriented studies
    Miguel Castro-Rodríguez, Luis Díaz-Gómez, Yolanda Sanz, Carmen Alvarez‐Lorenzo, María Vallet‐Regí · 2026 · Frontiers in Biomaterials Science
50. Senescent immune cells, inflammaging, and bone loss: therapeutic potential and translational challenges of senolytics in osteoporosis
    Minshun Zhu, Jie Zhang, Houshan Fang, Kuo Cai, Qing Wu, Changping Gao, Yueling Wang, Jiaping Chen · 2026 · Frontiers in Endocrinology
51. Single-cell profiling reveals senescent bone marrow mesenchymal stem cell subpopulations driving pathological ossification in ankylosing spondylitis
    Xiqing Luo, Jinwei Li, Jun Qi, Churong Lin, Jingxiao Wu, Ou Jin, Jieruo Gu · 2026 · Lara D. Veeken
52. Frequency and Systemic Associations of Focal Low-Trabeculation/Low-Density Intramedullary Jawbone Findings: A Retrospective CBCT Study
    Marzena Dominiak, Wojciech Niemczyk, Artur Pitułaj, Witold Świenc, Sebastian Dominiak, Konstanty Sławecki, Łucja Janek, Jacek Matys · 2026 · Journal of Clinical Medicine
53. Chronobiology of fracture repair: local molecular clocks, rhythm protection, and time-anchored translation
    Wenjie Lu, Nana Jiang, Jiaming Zhang, Jinzhong Wang, Zhimin Wu, Jianmiao Jin · 2026 · Frontiers in Endocrinology
54. Naringin attenuates orchidectomy-induced bone loss in male rats: evidence from bone remodeling and telomere-related indices
    Yelin Zhong, Guoying Wu, Shishuo Xiong, Yukai Zhang, Zehua Guo, Wenhao Lu, Qing Lan, Zijun Zeng, Delong Chen, Haiwei Guo et al. · 2026 · Journal of Molecular Histology
55. Traditional Chinese medicine regulating Wnt/β-catenin and OPG/RANKL/RANK pathways in osteoporosis: a narrative review based on bone coupling and pathological subtype differences
    S.P. Song, Jian-Min Li, Shengyi Feng, Hai-Ming Lu · 2026 · Frontiers in Medicine
56. Bone Aging and Glycative Stress: Convergent and Divergent Mechanisms Driving Skeletal Deterioration
    Salvador Peñarrubia, Eduardo Martín‐Guerrero, Arancha R. Gortázar, Juan Antonio Ardura · 2026 · Cells
57. Osteoimmune senescence in aging bone: from inflammaging dogma to cell-type-specific therapeutic windows
    Lan Zhang, Yao Yao, Jinxu Chen · 2026 · Frontiers in Immunology
58. Cellular senescence and the SASP in skeletal ageing: convergent mechanisms of progressive bone loss in osteoporosis
    Haotian Liu, Bingjun Lei · 2026 · Biogerontology
59. Future directions of osteoanabolic therapies in osteoporosis: Integrating current anabolic agents and emerging senescence-targeted strategies
    Hannah W. Brooks, Nicholas C. Cusick, Shuang Wu, Joshua N. Farr · 2026 · Best Practice & Research Clinical Rheumatology
60. Therapeutic potential of [6]-gingerol in musculoskeletal diseases through modulation of inflammation and oxidative stress: A mini-review
    Phuong Thao Nhi Nguyen, That Hoan Vu Ton · 2026 · Journal of Herbmed Pharmacology
61. Chronic Stress Exacerbates Osteoporosis in Ovariectomized Mice With Anxiety‐ and Depression‐Like Symptoms by Activating Cathepsin K and Impairing Autophagy
    Shanqian Li, Hongyu Ding, Yue Huang, Chaozhi Xu, Wanhua Wu, Guixian Wu, Yulin Zhang, Zongyi Zhang, Yue Hu, Lin Yang et al. · 2026 · Journal of Cellular Biochemistry
62. Microenvironmental barriers to healing in osteoradionecrosis and opportunities for regenerative intervention
    Aleyna E. La Croix, Maria Eduarda Torres Gouveia, Peter M. Bertone, Neva M. Nemanic, Chelsea S. Bahney, Katherine R. Hixon · 2026 · Bioactive Materials
63. The aging secretome as a candidate driver of bone remodeling imbalance: myokines, adipokines, and senescence-associated secretory factors
    Hanhong Fang, Xianglong Zhou, Yang Liu, Weicheng Chen, Fulin Zhou, Haoran Zhou, Jianhui Xiang, Liming Xiong · 2026 · Frontiers in Endocrinology