Farr, Joshua N.

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell

Telomeres, Telomerase, and SenescenceCircadian rhythm and melatonin

Cited by 2,562

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 2,287

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J. N., Xu, M., Weivoda, M. M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., et al. (2017) · Nature Medicine

Telomeres, Telomerase, and SenescenceBone Metabolism and Diseases

Cited by 1,182

Identification of senescent cells in the bone microenvironment

Farr, J. N., Fraser, D. G., Wang, H., Jaehn, K., Ogrodnik, M. B., Weivoda, M. M., Drake, M. T., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., et al. (2016) · Journal of Bone and Mineral Research

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 562

The role of cellular senescence in ageing and endocrine disease

Khosla, S., Farr, J. N., Tchkonia, T., & Kirkland, J. L. (2020) · Nature Reviews Endocrinology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 523

In Vivo Assessment of Bone Quality in Postmenopausal Women With Type 2 Diabetes

Farr, J. N., Drake, M. T., Amin, S., Melton, L. J., McCready, L. K., & Khosla, S. (2014) · Journal of Bone and Mineral Research

Bone health and osteoporosis researchHIV-related health complications and treatments

Cited by 499

Cellular senescence in bone

Farr, J. N., & Khosla, S. (2019) · Bone

Telomeres, Telomerase, and SenescenceBone Metabolism and Diseases

Cited by 263

Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus

Khosla, S., Samakkarnthai, P., Monroe, D. G., & Farr, J. N. (2021) · Nature Reviews Endocrinology

Bone health and osteoporosis researchBone Metabolism and Diseases

Cited by 260

Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Weivoda, M. M., Chew, C. K., Monroe, D. G., Farr, J. N., Atkinson, E. J., Geske, J. R., Eckhardt, B., Thicke, B., Ruan, M., Tweed, A. J., et al. (2020) · Nature Communications

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 230

Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss

Chandra, A., Lagnado, A. B., Farr, J. N., Monroe, D. G., Park, S., Hachfeld, C., Tchkonia, T., Kirkland, J. L., Khosla, S., Passos, J. F., et al. (2020) · Journal of Bone and Mineral Research

Telomeres, Telomerase, and SenescenceEffects of Radiation Exposure

Cited by 138

Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry-based assay

Bergen, H. R., Farr, J. N., Vanderboom, P. M., Atkinson, E. J., White, T. A., Singh, R. J., Khosla, S., & LeBrasseur, N. K. (2015) · Skeletal Muscle

Muscle Physiology and DisordersNutrition and Health in Aging

Cited by 137

Sympathetic β1-adrenergic signaling contributes to regulation of human bone metabolism

Khosla, S., Drake, M. T., Volkman, T. L., Thicke, B. S., Achenbach, S. J., Atkinson, E. J., Joyner, M. J., Rosen, C. J., Monroe, D. G., & Farr, J. N. (2018) · Journal of Clinical Investigation

Bone health and osteoporosis researchBone Metabolism and Diseases

Cited by 132

Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis

Khosla, S., Farr, J. N., & Kirkland, J. L. (2018) · The Journal of Clinical Endocrinology & Metabolism

Telomeres, Telomerase, and SenescenceBone Metabolism and Diseases

Cited by 130

Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes

Eckhardt, B. A., Rowsey, J. L., Thicke, B. S., Fraser, D. G., O’Grady, K. L., Bondar, O. P., Hines, J. M., Singh, R. J., Thoreson, A. R., Rakshit, K., et al. (2020) · JCI Insight

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 130

Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial

Farr, J. N., Atkinson, E. J., Achenbach, S. J., Volkman, T. L., Tweed, A. J., Vos, S. J., Ruan, M., Sfeir, J., Drake, M. T., Saul, D., et al. (2024) · Nature Medicine

Telomeres, Telomerase, and SenescenceBone health and osteoporosis research

Cited by 127

Targeted clearance of p21 ‐ but not p16 ‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity

Chandra, A., Lagnado, A. B., Farr, J. N., Doolittle, M., Tchkonia, T., Kirkland, J. L., LeBrasseur, N. K., Robbins, P. D., Niedernhofer, L. J., Ikeno, Y., et al. (2022) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 120

LPS-induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis

Aquino-Martinez, R., Rowsey, J. L., Fraser, D. G., Eckhardt, B. A., Khosla, S., Farr, J. N., & Monroe, D. G. (2020) · Bone

Telomeres, Telomerase, and SenescenceBone Metabolism and Diseases

Cited by 114

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

Farr, J. N., Saul, D., Doolittle, M. L., Kaur, J., Rowsey, J. L., Vos, S. J., Froemming, M. N., Lagnado, A. B., Zhu, Y., Weivoda, M., et al. (2023) · Journal of Clinical Investigation

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 81

Relationship of Sympathetic Activity to Bone Microstructure, Turnover, and Plasma Osteopontin Levels in Women

Farr, J. N., Charkoudian, N., Barnes, J. N., Monroe, D. G., McCready, L. K., Atkinson, E. J., Amin, S., Melton, L. J., Joyner, M. J., & Khosla, S. (2012) · The Journal of Clinical Endocrinology & Metabolism

Bone health and osteoporosis researchBone Metabolism and Diseases

Cited by 79

Senescent cells exacerbate chronic inflammation and contribute to periodontal disease progression in old mice

Aquino‐Martinez, R., Eckhardt, B. A., Rowsey, J. L., Fraser, D. G., Khosla, S., Farr, J. N., & Monroe, D. G. (2021) · Journal of Periodontology

Oral microbiology and periodontitis researchTelomeres, Telomerase, and Senescence

Cited by 78

Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing

Farr, J. N., Roforth, M. M., Fujita, K., Nicks, K. M., Cunningham, J. M., Atkinson, E. J., Therneau, T. M., McCready, L. K., Peterson, J. M., Drake, M. T., et al. (2015) · PLOS ONE

Bone health and osteoporosis researchEstrogen and related hormone effects

Cited by 75

Modulation of fracture healing by the transient accumulation of senescent cells

Saul, D., Monroe, D. G., Rowsey, J. L., Kosinsky, R. L., Vos, S. J., Doolittle, M. L., Farr, J. N., & Khosla, S. (2021) · eLife

Telomeres, Telomerase, and SenescenceBone fractures and treatments

Cited by 71

Osteocyte Cellular Senescence

Farr, J. N., Kaur, J., Doolittle, M. L., & Khosla, S. (2020) · Current Osteoporosis Reports

Telomeres, Telomerase, and SenescenceBone Metabolism and Diseases

Cited by 60

Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

Doolittle, M. L., Saul, D., Kaur, J., Rowsey, J. L., Vos, S. J., Pavelko, K. D., Farr, J. N., Monroe, D. G., & Khosla, S. (2023) · Nature Communications

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 57